EIT Imaging of Intracranial Hemorrhage in Rabbit Models Is Influenced by the Intactness of Cranium

Dai, Meng; Liu, Xuechao; Li, Haoting; Xu, Canhua; Yang, Bin; Wang, Hang; Shi, Xuetao; Dong, Xiuzhen; Fu, Feng

doi:10.1155/2018/1321862

Cited by 10 publications

(12 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such a small blood infiltration in the surrounding healthy parenchyma could make the MRR clustering unable to distinguish the boundary real hemorrhage-healthy tissues that instead appears evident from the histopathology after the brain fixation. This hypothesis related to heparinization is supported by the work of Dai et al (2018), where authors, contrary to what has been herein described, used autologous nonheparinized blood into cerebral parenchyma for their experiment and observed in their results a clear distinction between hemorrhagic tissue and parenchyma [42].…”

Section: Discussionsupporting

confidence: 61%

“…As far as it strictly concerns the histopathology findings, in acute human spontaneous intracerebral hemorrhages, as well as in those induced by injecting blood in different animal models (42), primary tissue damage is followed by secondary pathological lesions, in which cellular and neuroinflammatory changes are poorly defined. Most of the studies published on this topic refer to 24/48 hours postmortem histological changes [43,44], especially focusing on the time and mass effect of the lesion, cerebral edema, and ischemic cell changes affecting the adjacent neural tissue.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

MR relaxometry-based analysis of brain hemorrhages: an experimental study on a rabbit model

Signore

Vignoli

Salda

et al. 2021

Preprint

View full text Add to dashboard Cite

Magnetic Resonance Relaxometry is a quantitative MRI-based technique able to estimate tissue relaxation times T1 and T2. This approach allows increasing the MRI diagnostic accuracy mostly in case of brain neoplasia or neurodegenerative disorders in human medicine. However, few reports are available on the application of this technique in the clinical field of veterinary medicine. For this reason, in this work, we developed a relaxometry based approach on experimentally induced brain hemorrhages on rabbits. Specifically, the methodology is based on a hierarchical clustering procedure driven by the T1 relaxometry signals from a set of regions of interest selected on the T2 map. The approach is multivariate since it combines both T1 and T2 information and allows the diagnosis at the subject level by comparing “suspected” pathological regions with healthy homologous ones within the same brain.To validate the proposed technique, the scanned brains underwent histopathological analyses to estimate the performance of the proposed classifier in terms of Receiver Operator Curve analyses. The results showed that, in terms of identification of the lesion and its contours, the proposed approach resulted accurate and outperformed the standard techniques based on T1w and T2w images. Finally, since the proposed protocol in terms of the adopted scanner, sequences, and analysis tools, is suitable for the clinical practice, it can be potentially validated through large-scale multi-center clinical studies.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

MR relaxometry-based analysis of brain hemorrhages: an experimental study on a rabbit model

Signore

Vignoli

Salda

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…This phantom provides a standardized, efficient, and reproducible method for the construction of a head phantom for EIT that could be easily adapted to other fields in brain function research, such as transcranial direct current stimulation and EEG [120]. The FMMU group also confirmed that cranium completeness (open or closed) affects impedance changes within the brain when using EIT to monitor ICH [88]. Hence, cranium completeness should be considered when establishing an ICH model and analyzing the corresponding EIT results.…”

Section: Modeling Accuracymentioning

confidence: 93%

“…Most patients with ICH require a craniotomy. Dai and colleagues [88] investigated the effects of an open or closed cranium on impedance changes in the brain in a rabbit ICH model and reported that cranium completeness (open or closed) influenced impedance changes within the brain when using EIT to monitor ICH. Therefore, cranium completeness should be considered in future studies when applying EIT to monitor cerebral hemorrhage.…”

Section: Strokementioning

confidence: 99%

Advances in electrical impedance tomography-based brain imaging

Hou

Huang

et al. 2022

Military Med Res

View full text Add to dashboard Cite

Novel advances in the field of brain imaging have enabled the unprecedented clinical application of various imaging modalities to facilitate disease diagnosis and treatment. Electrical impedance tomography (EIT) is a functional imaging technique that measures the transfer impedances between electrodes on the body surface to estimate the spatial distribution of electrical properties of tissues. EIT offers many advantages over other neuroimaging technologies, which has led to its potential clinical use. This qualitative review provides an overview of the basic principles, algorithms, and system composition of EIT. Recent advances in the field of EIT are discussed in the context of epilepsy, stroke, brain injuries and edema, and other brain diseases. Further, we summarize factors limiting the development of brain EIT and highlight prospects for the field. In epilepsy imaging, there have been advances in EIT imaging depth, from cortical to subcortical regions. In stroke research, a bedside EIT stroke monitoring system has been developed for clinical practice, and data support the role of EIT in multi-modal imaging for diagnosing stroke. Additionally, EIT has been applied to monitor the changes in brain water content associated with cerebral edema, enabling the early identification of brain edema and the evaluation of mannitol dehydration. However, anatomically realistic geometry, inhomogeneity, cranium completeness, anisotropy and skull type, etc., must be considered to improve the accuracy of EIT modeling. Thus, the further establishment of EIT as a mature and routine diagnostic technique will necessitate the accumulation of more supporting evidence.

show abstract

“…EIT is often used in the treatment of some lung failure diseases (Frerichs and Zhao, 2019). In addition to the application in lung diseases, there are also some clinical applications in tumor detection or early detection of some diseases for EIT (Ma et al, 2014;Dai et al, 2018;Lee et al, 2020;Yang et al, 2020). With the continuous development of EIT theory and technology, the clinical application of EIT technology will be more and more.…”

Section: Neonatal Pulmonary Function Imagingmentioning

confidence: 99%

The Research Progress of Electrical Impedance Tomography for Lung Monitoring

Shi

Yang

Xie

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Medical imaging can intuitively show people the internal structure, morphological information, and organ functions of the organism, which is one of the most important inspection methods in clinical medical diagnosis. Currently used medical imaging methods can only be applied to some diagnostic occasions after qualitative lesions have been generated, and the general imaging technology is usually accompanied by radiation and other conditions. However, electrical impedance tomography has the advantages of being noninvasive and non-radiative. EIT (Electrical Impedance Tomography) is also widely used in the early diagnosis and treatment of some diseases because of these advantages. At present, EIT is relatively mature and more and more image reconstruction algorithms are used to improve imaging resolution. Hardware technology is also developing rapidly, and the accuracy of data collection and processing is continuously improving. In terms of clinical application, EIT has also been used for pathological treatment of lungs, the brain, and the bladder. In the future, EIT has a good application prospect in the medical field, which can meet the needs of real-time, long-term monitoring and early diagnosis. Aiming at the application of EIT in the treatment of lung pathology, this article reviews the research progress of EIT, image reconstruction algorithms, hardware system design, and clinical applications used in the treatment of lung diseases. Through the research and introduction of several core components of EIT technology, it clarifies the characteristics of EIT system complexity and its solutions, provides research ideas for subsequent research, and once again verifies the broad development prospects of EIT technology in the future.

show abstract

EIT Imaging of Intracranial Hemorrhage in Rabbit Models Is Influenced by the Intactness of Cranium

Cited by 10 publications

References 29 publications

MR relaxometry-based analysis of brain hemorrhages: an experimental study on a rabbit model

MR relaxometry-based analysis of brain hemorrhages: an experimental study on a rabbit model

Advances in electrical impedance tomography-based brain imaging

The Research Progress of Electrical Impedance Tomography for Lung Monitoring

Contact Info

Product

Resources

About