Kamindla Rajesh, Andreas I. Papadakis, Urszula Kazimierczak, Philippos Peidis, Shuo Wang, Gerardo Ferbeyre, Randal J. Kaufman, Antonis E. Koromilas
Abstract:Eukaryotic cells respond to various forms of stress by blocking mRNA translation initiation via the phosphorylation of the alpha (α) subunit of eIF2 at serine 51 (S51) (eIFαP). An important role of eIF2αP is the regulation of redox homeostasis and adaptation of cells to oxidative stress. Herein, we demonstrate that eIF2αP guards cells from intracellular reactive oxygen species (ROS) via the inhibition of senescence. Specifically, genetic inactivation of either eIF2αP or eIF2α kinase PERK in primary mouse or hu…
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