2011
DOI: 10.1007/s10616-011-9386-1 View full text |Buy / Rent full text
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Abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a persistent and ubiquitous environmental contaminant. The health impact of TCDD exposure is of great concern to the general public. Recent reports have implied that eicosapentaenoic acid (EPA) might be a potential chemopreventive agent and influence hepatotoxicity. The aim of the current study was to explore the effectiveness of EPA in alleviating the toxicity of TCDD on primary cultured rat hepatocytes. EPA (5, 10 and 20 lM) was added to cultures alone or simulta… Show more

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“…Moreover the mechanism of Nrf-2-dependent antioxidant response was reported to be mediated by EFOX (electrophilic fatty acid oxo-derivatives) derivatives from EPA and DHA (Groeger et al 2010). However, a recent study by Turkez et al (2012) has shown that EPA provided cytoprotection against TCDD-induced stress by enhancing the total antioxidant capacity in rat hepatocytes. The protective effect of fish oil rich in n-3 fatty acids against various nephrotoxic conditions (Goksu Erol et al 2013;Priyamvada et al 2008;Naqshbandi et al 2012;Thakkar et al 2000;Xi and Chen 2000) and results from the present study strongly support the ability of EPA as a potent nephroprotectant.…”
Section: Discussionmentioning
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“…Moreover the mechanism of Nrf-2-dependent antioxidant response was reported to be mediated by EFOX (electrophilic fatty acid oxo-derivatives) derivatives from EPA and DHA (Groeger et al 2010). However, a recent study by Turkez et al (2012) has shown that EPA provided cytoprotection against TCDD-induced stress by enhancing the total antioxidant capacity in rat hepatocytes. The protective effect of fish oil rich in n-3 fatty acids against various nephrotoxic conditions (Goksu Erol et al 2013;Priyamvada et al 2008;Naqshbandi et al 2012;Thakkar et al 2000;Xi and Chen 2000) and results from the present study strongly support the ability of EPA as a potent nephroprotectant.…”
Section: Discussionmentioning
“…After incubation with compounds for 24 h, MTT solution (final amount 10 lL) was added to each well and re-incubated for 4 h at 37°C. After washing, the blue formazan was extracted from the cells with isopropanol/formic acid (95:5) and was photometrically determined at 560 nm (Lewerenz et al 2003;Turkez et al 2012b;Aydın et al 2014). …”
Section: Cytotoxicity Assaymentioning
“…These include vitamins, fatty acids and antibody (Edenharder et al 1999;Rao et al 2001;Yoshida et al 2010;Turkez et al 2012b). Concomitant treatment with the anti-oxidants provided protection against oxidative damage by mutagens in experimental animals (Abubakar et al 2003;Esparza et al 2003;Geyikoglu et al 2005;.…”
Section: Introductionmentioning