Biochemical Pharmacology volume 81, issue 9, P1087-1097 2011 DOI: 10.1016/j.bcp.2011.02.006 View full text
Sarra Chbicheb, Xiao Yao, Jean-Luc Rodeau, Stéphane Salamone, Michel Boisbrun, Gerald Thiel, Daniel Spohn, Isabelle Grillier-Vuissoz, Yves Chapleur, Stéphane Flament, Sabine Mazerbourg

Abstract: Our aim was to get new information about the Peroxisome Proliferator Activated Receptor gamma (PPARγ)-independent pathway involved in the antiproliferative action of PPARγ ligands in breast cancer cells. We investigated the effects of Troglitazone (TGZ), Ciglitazone (CGZ), Rosiglitazone (RGZ) and, 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ(2)) on the hormone-dependent breast cancer cell line MCF7. The early transcription factor EGR1 (Early Growth Response gene 1) mRNA and protein levels peaked after 3h of incub…

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