Egg oral immunotherapy in nonanaphylactic children with egg allergy

Buchanan, Ariana D.; Green, Todd D.; Jones, Stacie M.; Scurlock, Amy M.; Christie, Lynn; Althage, K.A.; Steele, Pamela H.; Pons, Laurent; Helm, R.M.; Lee, Laurie A.; Burks, A. Wesley

doi:10.1016/j.jaci.2006.09.016

Cited by 352 publications

(257 citation statements)

References 32 publications

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“…Although within the allergy research field there is a great deal of discussion concerning the effectiveness of OIT, it has been demonstrated that the OIT protocols could show good results for allergies to cow's milk and peanut, for example [9,[22][23][24]. Although OIT seems to be a promising therapeutic strategy, there is a high risk of systemic reactions during this procedure, and because of remaining unanswered questions, this type of therapy is not ready to be implemented fully.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that beyond neutralization, IgG (IgG1 in mice and IgG4 in humans) blocks mast cell activation [25] and can even protect IgE-mediated anaphylaxis [26]. Indeed, this is one of the explanations of why the IgE levels do not necessarily decrease during oral immunotherapy despite showing efficiency, both in humans and in murine experimental models [22,23,27]. In our model, prolonged ingestion of OVA for 14 days by sensitized mice protected them against anaphylactic shock when the antigen was given systemically in a dose of 2 mg, and the balance of those immunoglobulins is one of the factors that might be contributing to this response, together with other tolerogenic mechanisms that will be investigated in a future work.…”

Section: Discussionmentioning

confidence: 99%

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Prolonged ingestion of ovalbumin diet by sensitized mice improves the metabolic consequences induced by experimental food allergy

Batista¹,

Pereira²,

Noviello³

et al. 2014

Clinical and Experimental Immunology

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SummaryThe prevalence of food allergy is rising in the western world. Allergen restriction is the chosen treatment in this condition, but continuous ingestion of the antigen has shown positive results in clinical trials. In a previous study, we have shown several allergic and metabolic alterations after 7 days of ovalbumin (OVA) ingestion by sensitized mice. The aim of this study was to investigate whether prolonged ingestion of antigen by sensitized mice would reverse the metabolic consequences caused by experimental food allergy. For this, allergic and metabolic parameters were analysed after prolonged ingestion of an OVA diet by OVA-sensitized mice. As shown previously, after 7 days of OVA consumption, sensitized mice showed increased serum levels of anti-OVA immunoglobulin (Ig)E and IgG1, aversion to the antigen ingestion, marked body and adipose tissue weight loss, followed by adipose tissue inflammation and decreased serum levels of adipokines, glucose and triglycerides. However, after 14 days of oral challenge, sensitized mice showed an anti-OVA IgE level similar to the mice that were only sensitized, but the specific IgG1 did not change. With this prolonged ingestion of OVA, sensitized mice were protected from OVA-induced anaphylaxis when the antigen was given systemically at a dose of 2 mg/animal. Moreover, various parameters analysed were significantly ameliorated, including adipose tissue inflammation, body and adipose tissue loss, as well as serum levels of adipokines and triglycerides. Therefore, our data suggest that prolonged ingestion of OVA by sensitized mice results in an improvement of the metabolic consequences caused by experimental food allergy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prolonged ingestion of ovalbumin diet by sensitized mice improves the metabolic consequences induced by experimental food allergy

Batista¹,

Pereira²,

Noviello³

et al. 2014

Clinical and Experimental Immunology

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“…In another early trial, Buchanan et al [28] reported on 7 children aged 14 months to 7 years who received 24 months of egg OIT at a maintenance dose of 300 mg of daily, with 57% passing an oral food challenge at completion of treatment. In a follow-up study at the same center, patients treated with a higher, individualized dose (median 2400 mg) for a median of 33 months had an SU rate of 75% (6 of 8 patients) 1 month after stopping treatment [29].…”

Section: Egg Oitmentioning

confidence: 99%

Oral Immunotherapy for Food Allergy

Wood

2017

J Investig Allergol Clin Immunol

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Food allergy is a potentially life-threatening condition with no approved therapies apart from avoidance and injectable epinephrine for treatment of acute allergic reactions. Oral immunotherapy (OIT) is an experimental treatment in which patients consume gradually increasing quantities of the food to which they are allergic in an attempt to induce some level of desensitization. While desensitization is possible in most patients, OIT carries significant risks for allergic reactions, and the ability to induce longer-term tolerance has not yet been established. This review focuses on selected studies of OIT for the treatment of common food allergies such as cow's milk, hen's egg, and peanut. Key words: Food allergy. Oral immunotherapy. Cow's milk. Hen's egg. Peanut. Desensitization. Tolerance. Sustained unresponsiveness. Skin prick test (SPT). Immunoglobulin E (IgE). Omalizumab. ResumenLa alergia alimentaria es una condición potencialmente mortal para la que no existen tratamientos aprobados, excepto la evitación y la epinefrina para tratar reacciones alérgicas graves. La inmunoterapia oral (OIT) es un tratamiento experimental en el cual los pacientes ingieren cantidades gradualmente crecientes del alimento al que son alérgicos, con el fin de inducir algún nivel de desensibilización. Si bien la desensibilización es posible en la mayoría de los pacientes, OIT conlleva riesgos importantes de reacciones alérgicas y la capacidad de inducir tolerancia a más largo plazo todavía no ha sido establecida. Este artículo de revisión se centra en una selección de estudios de OIT para el tratamiento de alergias a alimentos comunes, como son la leche de vaca, huevos de gallina y cacahuete. Palabras clave: Alergia alimentaria. Inmunoterapia oral. Leche de vaca. Huevo de gallina. Cacahuete. Desensibilización. Tolerancia. Falta de respuesta sostenida. Prick test. Inmunoglobulina. Omalizumab.

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“…Recently, oral immunotherapy (OIT) has been studied for milk, egg and peanut allergies [3][4][5][6][7][8][9][10][11][12][13]. These studies have shown that many individuals with severe allergy to these foods can be successfully desensitized and, in some cases, can even introduce the food into their diets.…”

mentioning

confidence: 99%

“…A few studies have attempted to address the question of whether these OIT protocols confer long-term tolerance along with short-term desensitization. It appears that between a third and a half of children treated with OIT for milk or egg allergy are truly tolerant, in that they are able to eat the food after all exposure was stopped [3,12].…”

mentioning

confidence: 99%