2007
DOI: 10.1242/jcs.000653
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Abstract: In epithelia, junction proteins are endocytosed for modulation of cell-cell adhesion and cell polarity. In response to growth factors, the cell-cell adhesion protein E-cadherin is internalized from the cell surface with degradation or recycling as potential fates. However, the cellular machinery involved in cadherin internalization and recycling remains controversial. Here we investigated EGF-induced E-cadherin internalization. EGF stimulation of MCF-7 cells resulted in Rac1-modulated macropinocytosis of the E… Show more

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Cited by 170 publications
(195 citation statements)
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“…This was first suggested by the observation that cadherin internalisation increased when cell-cell contacts were broken by chelating extracellular calcium [3,20]. Similarly, EGF induced internalisation of E-cadherin by macropinocytosis in subconfluent, but not confluent, cultures [5]. Consistent with this, Izumi et al (2004) reported that it was the free cadherin, rather than the cadherins engaged in adhesion, that underwent endocytosis in cell-free assays.…”
Section: Regulating Internalisation: the Yin And Yang Of Adhesion Andmentioning
confidence: 78%
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“…This was first suggested by the observation that cadherin internalisation increased when cell-cell contacts were broken by chelating extracellular calcium [3,20]. Similarly, EGF induced internalisation of E-cadherin by macropinocytosis in subconfluent, but not confluent, cultures [5]. Consistent with this, Izumi et al (2004) reported that it was the free cadherin, rather than the cadherins engaged in adhesion, that underwent endocytosis in cell-free assays.…”
Section: Regulating Internalisation: the Yin And Yang Of Adhesion Andmentioning
confidence: 78%
“…Endocytosis can also be substantially altered in response to external stimuli. For example, E-cadherin internalisation is increased when subconfluent epithelial cultures are treated with EGF [5] while VEGF induces the internalisation of VE-cadherin [6••]. Conversely, uptake of N-cadherin in cultured hippocampal neurons was decreased upon stimulation of NMDA receptors [7•].…”
Section: Regulating Internalisation: the Yin And Yang Of Adhesion Andmentioning
confidence: 99%
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“…Internalization of classic cadherins occurs via both clathrin-dependent and -independent pathways (Lu et al, 2003;Paterson et al, 2003;Bryant and Stow, 2004;D'Souza-Schorey, 2005;Bryant et al, 2007). However, little is known about trafficking pathways in which desmosomal cadherins are engaged.…”
Section: Discussionmentioning
confidence: 99%
“…Macropinosomes may also acquire Rab34 and early endosome antigen 1 (EEA1) needed for pinosome formation and fusion 19, 20. Acquisition of sorting nexins (SNXs) promotes tubulation to facilitate cargo recycling and macropinosome maturation 21, 22, 23, 24, 25. As they move deeper into the cytoplasm, macropinosomes acidify and acquire Rab7, Rab21 and lysosome‐associated membrane protein 1 (LAMP1) 26, 27.…”
mentioning
confidence: 99%