Wei Li, Shu Zhu, Jianhua Li, Andrei Assa, Arvin Jundoria, Jianying Xu, Saijun Fan, N. Tony Eissa, Kevin J. Tracey, Andrew E. Sama, Haichao Wang
AbstractHistorically, consumption of Green tea (Camellia sinensis) has been associated with health benefits against multiple diseases including cancer, atherosclerosis and cardiovascular disorders. Emerging evidence has suggested a pathogenic role for HMGB1, a newly identified "late" mediator of lethal systemic inflammation, in the aforementioned diseases. Here we demonstrated that a major ingredient of Green tea, EGCG, was internalized into HMGB1-containing LC3-positive cytoplasmic vesicles (likely autophago…
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