Biochemical Pharmacology volume 81, issue 9, P1152-1163 2011 DOI: 10.1016/j.bcp.2011.02.015 View full text
Wei Li, Shu Zhu, Jianhua Li, Andrei Assa, Arvin Jundoria, Jianying Xu, Saijun Fan, N. Tony Eissa, Kevin J. Tracey, Andrew E. Sama, Haichao Wang

Abstract: AbstractHistorically, consumption of Green tea (Camellia sinensis) has been associated with health benefits against multiple diseases including cancer, atherosclerosis and cardiovascular disorders. Emerging evidence has suggested a pathogenic role for HMGB1, a newly identified "late" mediator of lethal systemic inflammation, in the aforementioned diseases. Here we demonstrated that a major ingredient of Green tea, EGCG, was internalized into HMGB1-containing LC3-positive cytoplasmic vesicles (likely autophago…

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