2020
DOI: 10.1002/jcp.29451
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Abstract: Copper transporter 1 (CTR1) plays an important role in increasing cisplatin intake. Our previous studies showed that CTR1 expression was upregulated by (−)‐epigallocatechin‐3‐gallate (EGCG), a green tea polyphenol, therefore enhanced cisplatin sensitivity in ovary cancer and non‐small‐cell lung cancer (NSCLC) cells. In the current study in the non‐small‐cell lung cancer cells, we uncovered a potential mechanism of EGCG‐induced CTR1 through its pro‐oxidative property. We found that EGCG increased reactive oxyge… Show more

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Cited by 42 publications
(18 citation statements)
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“…The cells susceptible to EGCG-induced apoptosis also showed activation of caspase-3 [ 38 ]. Moreover, the increased ROS level was observed to result in the stimulation of mitogen-activated protein kinase (MAPK) [ 39 ]. The MAPK signaling pathway, including extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNKs), and p38, plays a vital contribution in cell proliferation, differentiation, apoptosis, and stress response.…”
Section: Health Benefitsmentioning
confidence: 99%
See 1 more Smart Citation
“…The cells susceptible to EGCG-induced apoptosis also showed activation of caspase-3 [ 38 ]. Moreover, the increased ROS level was observed to result in the stimulation of mitogen-activated protein kinase (MAPK) [ 39 ]. The MAPK signaling pathway, including extracellular signal-regulated kinase (ERK), Jun N-terminal kinase (JNKs), and p38, plays a vital contribution in cell proliferation, differentiation, apoptosis, and stress response.…”
Section: Health Benefitsmentioning
confidence: 99%
“…Copper transporter 1 (CTR1) is a critical determinant to increase cisplatin uptake. EGCG could upregulate CTR1 expression through the stimulation of ROS [ 39 ]. Simultaneous treatment of arsenic trioxide (ATO) with EGCG showed oxidative-mediated induction of apoptosis in leukemia cancer cells [ 46 ].…”
Section: Health Benefitsmentioning
confidence: 99%
“…The JNK pathway was found to be another target of EGCG to induce cell cycle arrest [ 128 ]. EGCG exerted pro-oxidative property by modulating ROS level to inhibit ERK1/2 pathway [ 129 ].…”
Section: The Potential Use Of Phytochemical Compounds For Prevention and Targeting Cscs In Lung Cancermentioning
confidence: 99%
“…In mitochondria, polyphenols can undergo transition-metal catalyzed autoxidation to produce superoxide anions (O 2 •− ), which generate H 2 O 2 and hydroxyl radicals. For example, EGCG (epigallocatechin gallate), a green tea catechin, can markedly increase ROS production and positively regulate expression of CTR1 (cationic transporter receptor type 1), a relevant transporter for cisplatin intake [ 70 ]. EGCG autoxidizes due to its chemical instability under experimental conditions both in vivo and in vitro, resulting in H 2 O 2 production [ 71 ].…”
Section: Polyphenols As Mitochondrial-disrupting Agents Targeting mentioning
confidence: 99%