Biochemical Pharmacology volume 82, issue 9, P1153-1162 2011 DOI: 10.1016/j.bcp.2011.07.063 View full text
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Julia Hoffmann, Heike Junker, Annett Schmieder, Simone Venz, Rowena Brandt, Gabriele Multhoff, Werner Falk, Jürgen Radons

Abstract: Human pancreatic cancer is currently one of the fifth-leading causes of cancer-related mortality with a 5-year survival rate of less than 5%. Since pancreatic carcinoma is largely refractory to conventional therapies, there is a strong medical need for the development of novel and innovative therapeutic strategies. Increasing evidence suggests an association of carcinogenesis and chronic inflammation. Because IL-1 plays a crucial role in inflammation-associated carcinogenesis, we analyzed the biological effect…

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