Efficient synthesis of AB ring core of luotonin A derivatives: (2-chloroquinolin-3-yl)methanamine

Roopan, Selvaraj Mohana; Khan, F. Nawaz; Jin, Jong Sung

doi:10.1007/s11164-011-0361-4

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Furthermore, the solid state reaction (or solvent-free reaction) has many advantages including reduced pollution, low costs and simplicity in process and handling, these factors are especially important in industry. [3][4][5][6][7] 1,4-dihydropyridines (1,4-DHPs) represent an important class of compounds which are found in many active biological products, such as vasodilator, bronchodilator and also they have been used as anti-atherosclerotic, antitumor, geroprotective, hepatoprotective and antidiabetic agents. 8 Numerous synthetic methods have been reported for the preparation of 1,4-dihydropyridine derivatives under classical or modified conditions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Evaluation of Some New 1,4-Dihydropyridines in the Presence of Fe3O4@Silica Sulfonic Acid Nanocomposite as Catalyst

Nasrollahi¹,

Ghasemzadeh²,

Zolfaghari³

2018

ACSi

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The synthesis of heterocyclic compounds has been a topic of significant interest because of their broad applications. In this research an effective and eco-friendly approach for the synthesis 1,4-dihydropyridines has been developed via the four-component reactions of arylamines, acetylenedicarboxylates, aromatic aldehydes and ethyl acetoacetate in the presence of Fe 3 O 4 @SiO 2 @OSO 3 H nanocomposite under solvent-free conditions. The advantages of this method involve the green reaction conditions, simple workup, broad substrates, excellent yields and the reuse of the nanocatalyst. One of the indicators to measure antimicrobial activity is Minimum Inhibitory Concentrations (MIC) that this measure and heterocyclic compounds synthesis inhibition zone diameter was measured on examined bacteria using well diffusion, disc diffusion and determination of antibiotic susceptibility. The results of all three methods suggested the susceptibility of Staphylococcus aureus to synthesized heterocyclic compounds. It can be concluded from the results that these compounds have high antibiotic properties and can be useful in other research and biomedical applications.

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