Efficient Phenylsulfenylation and Phenylselenenylation at the 5-Position of Uracil Nucleosides with Disulfide and Diselenide Mediated by [Bis(trifluoroacetoxy)-iodo]benzene

A NaI/H2O2-Mediated Sulfenylation and Selenylation of Unprotected Uracil and Its Derivatives

“…Although these methods are useful, most of them suffer from several limitations. For example, protection groups at the N -1 and N -3 positions of uracil were required in the prefunctionalization strategy; thus, unprotected uracil targets, like 5-phenylthiouracil in Figure , were not rapidly prepared through this approach . In addition, most of these methods involved toxic basic/acidic reagents and harsh reaction or inert atmosphere conditions.…”