Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

Barrachina, María N.; Pernes, Gerard; Becker, Isabelle C.; Allaeys, Isabelle; Hirsch, Thomas I; Groeneveld, Dafna; Khan, Abdullah O.; Freire, Daniela; Guo, K.; Carminita, Estelle; Morgan, Pooranee K; Collins, Thomas; Mellett, Natalie A.; Wei, Zimu; Almazni, Ibrahim; Italiano, Joseph E.; Luyendyk, James P.; Meikle, Peter J.; Puder, Mark; Morgan, Neil V.; Boilard, Éric; Murphy, Andrew; Machlus, Kellie R.

doi:10.1038/s44161-023-00305-y

Cited by 7 publications

(2 citation statements)

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“…Ferroptosis exhibits both morphological and biochemical differences in comparison to other conventional forms of RCD, mainly through the characteristic mitochondrial shrinkages that differentiate it from other RCDs. It has been acknowledged that severe peroxidation of membranes containing polyunsaturated fatty acids (PUFAs) is the primary driving force behind ferroptosis, which not only is regulated by lipid and iron metabolism but also involves amino acid metabolism and signaling transduction . The critical steps involved in ferroptosis include intracellular free iron accumulation, glutathione depletion, and peroxidation of PUFA-rich membranes .…”

Section: Ferroptosismentioning

confidence: 99%

“…It has been acknowledged that severe peroxidation of membranes containing polyunsaturated fatty acids (PUFAs) is the primary driving force behind ferroptosis, which not only is regulated by lipid and iron metabolism but also involves amino acid metabolism and signaling transduction. 8 The critical steps involved in ferroptosis include intracellular free iron accumulation, glutathione depletion, and peroxidation of PUFA-rich membranes. 9 These steps are summarized in Figure 1.…”

Section: Introductionmentioning

confidence: 99%

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Ferroptosis-Regulated Cell Death as a Therapeutic Strategy for Neurodegenerative Diseases: Current Status and Future Prospects

Zhang,

Jia,

Cao

et al. 2023

ACS Chem. Neurosci.

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Ferroptosis is increasingly being recognized as a key element in the pathogenesis of diverse diseases. Recent studies have highlighted the intricate links between iron metabolism and neurodegenerative disorders. Emerging evidence suggests that iron homeostasis, oxidative stress, and neuroinflammation all contribute to the regulation of both ferroptosis and neuronal health. However, the precise molecular mechanisms underlying the involvement of ferroptosis in the pathological processes of neurodegeneration and its impact on neuronal dysfunction remain incompletely understood. In our Review, we provide a comprehensive analysis and summary of the potential molecular mechanisms underlying ferroptosis in neurodegenerative diseases, aiming to elucidate the disease progression of neurodegeneration. Additionally, we discuss potential therapeutic agents that modulate ferroptosis with the goal of identifying novel drug molecules for the treatment of neurodegenerative disorders.

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Section: Ferroptosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%