“…Dilutions prepared using this technique were found to share a common feature—the ability to directly modify the initial substance, alter its spatial structure and, consequently, its physicochemical and biological properties. RAF-based drug products are referred to as “released-active”, with their efficacy and safety proven by both non-clinical and clinical studies [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. We also previously demonstrated the possibility of using ELISA tests for examining the effects of both antibody and non-antibody RAFs on the Ag-Abs interaction [ 40 , 41 ].…”