Efficacy of ω-3 Polyunsaturated Fatty Acids in Patients with Lung Cancer Undergoing Radiotherapy and Chemotherapy: A Meta-Analysis

Xin, Tao; Zhou, Qiang; Rao, Zhiyong

doi:10.1155/2022/6564466

Cited by 10 publications

(7 citation statements)

References 33 publications

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“…Cancer (0.51 to 2.2 g/day EPA and 0.24 to 0.92 g/day DHA; high vs. low blood levels DPA or DHA) ( 74 , 75 )…”

Section: Resultsmentioning

confidence: 99%

Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand

Starck,

Cassettari,

Beckett

et al. 2024

Front. Nutr.

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BackgroundThe double burden of malnutrition and diet-related disease has been attributed to diets high in ultra-processed and discretionary foods, with increased sugars, saturated fats, and sodium, and insufficient dietary fibre. There is a limited understanding of the role of other macronutrients and micronutrients.ObjectiveDetermine the highest priority nutrients to address both malnutrition and diet-related disease in Australia and New Zealand, for each demographic group and the total population.MethodsA novel four-step methodological approach was undertaken to identify: 1. Demographic (age-sex) groups; 2. Health priorities; 3. Potential nutrients based on inadequacy, increased requirements, and health priority association; and 4. Priority nutrients. Nutrient intake data was obtained from the most recent Australian and New Zealand nutrition surveys. Health priorities were based on national statistical data and expert consultation. High-level scientific literature (systematic reviews) was scoped for associations with health priorities and the suitability of recommended intakes. A quantitative scoring matrix was developed and used to determine the highest priority nutrients, with scoring over three domains: extent of inadequacy; consensus for increased requirements; and degree of association with health priorities.ResultsNutritional inadequacies were common, with 22 of 31 essential nutrients consumed below recommended levels. Nine priority nutrients were identified across the demographic groups, with each demographic group characterised by a specific subset of these. Six nutrients were highest priority within the total population: vitamin D, calcium, omega-3 fatty acids, magnesium, folate, dietary fibre.ConclusionThe extent of nutritional inadequacies in Australia and New Zealand is high, both within each demographic group and the entire population, relative to both recommended intakes and key health outcomes. The methodology can be applied to other countries and globally. Findings make a significant contribution to understanding the nutrients to prioritise in future-proofing the health of the Australian and New Zealand populations. Guidelines and policies can target priority nutrients to address the malnutrition and diet-related disease double burden.

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“…Cancer (0.51 to 2.2 g/day EPA and 0.24 to 0.92 g/day DHA; high vs. low blood levels DPA or DHA) ( 74 , 75 )…”

Section: Resultsmentioning

confidence: 99%

Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand

Starck,

Cassettari,

Beckett

et al. 2024

Front. Nutr.

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“…Given that a large body of research reports a positive impact of n -3 fatty acids on muscle mass, this intervention could be an effective and practical solution helping to prevent muscle loss without any major adverse effects [ 19 ]. In a meta-analysis by Thao et al, C Reactive Protein (CRP) and TNFα levels were significantly reduced, which suggests that ω-3 polyunsaturated fatty acids (PUFAs) may have some regulatory effect on inflammation in patients with lung cancer treated with chemotherapy and radiotherapy [ 20 ]. Patients suffering from malignant tumors display increased catabolism and resting energy expenditure [ 21 ].…”

Section: The Role Of Nutrients In Cancer Treatmentmentioning

confidence: 99%

Diet as a Factor Supporting Lung Cancer Treatment—A Systematic Review

et al. 2023

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The purpose of this study was to summarize the evidence from epidemiological studies concerning associations between diet and the effectiveness of treatment for lung cancer. For this review, a literature search has been conducted in the EMBASE and PubMed databases, including papers published between 1977 and June 2022. The term “lung cancer” was used in conjunction with “diet”. Footnotes from the selected papers were also analyzed. The present study is in line with the recommendations included in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The review included studies involving adults, including randomized controlled trials (RCTs) and cohort and observational studies. In total, 863 papers were found, with duplicates excluded. Ultimately, 20 papers were reviewed. The present systematic review indicates that vitamin A, ascorbic acid (vitamin C), vitamin E, selenium, and zinc—as antioxidants—can strengthen the body’s antioxidant barrier. Furthermore, preoperative immunonutrition may not only improve perioperative nutritional status following induction chemoradiotherapy in lung cancer surgery patients but also reduce the severity of postoperative complications. Similarly, a protein supply may exert a beneficial effect on human health by increasing average body weight and muscle mass. Omega-3 fatty acid content in the diet and the consumption of their main source, fish, may have some regulatory effect on inflammation in patients with lung cancer treated with chemotherapy and radiotherapy. In addition, n-3 fatty acids inhibit tumor cell proliferation and may reduce the toxicity of chemotherapy. Increased energy and protein intake are strongly associated with improved quality of life, functional outcomes, hand grip strength, symptoms, and performance in patients with lung cancer. The use of a supportive diet should be the standard of care, alongside pharmaceutical therapy, in treatment for patients with lung cancer.

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“…Omega-3 PUFA termasuk ke dalam kelompok asam lemak esensial yang tidak dapat disintesis oleh tubuh. Senyawa ini ditemukan berlimpah pada minyak nabati dan lemak ikan (Tao et al, 2022). Omega-3 sangat mudah ditemukan di kehidupan sehari-hari, mulai dari makanan yang sering dikonsumsi hingga suplemen yang dijual bebas.…”

Section: Omega-3unclassified

Omega-3 Memiliki Banyak Manfaat: Apakah Bisa Melawan Kanker?

Rudia,

Dwi,

Amelia

et al. 2023

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Cancer is the biggest cause of death in the world, around 10 million deaths are caused by cancer. In 2020, 17 million new cases were recorded, of which 8.5 million people died each yearfrom cancer,while 66% ofpatients canlive up to 5years after being diagnosed and 40% of patients can live more than 10 years after being diagnosed. Various prevention efforts against risk factors have been carried out. The main modalities of cancer therapy today are surgery, chemotherapy, and radiation with the choice of therapy based on the stage of the cancer. Research shows that giving omega-3 supplementation to patients undergoing chemotherapy is considered very beneficial because omega-3 works synergistically with chemotherapeutic agents and can also be used to increase the radiosensitivity of tumor cells so that it has a good impact on the success of therapy.

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Efficacy of ω-3 Polyunsaturated Fatty Acids in Patients with Lung Cancer Undergoing Radiotherapy and Chemotherapy: A Meta-Analysis

Cited by 10 publications

References 33 publications

Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand

Priority nutrients to address malnutrition and diet-related diseases in Australia and New Zealand

Diet as a Factor Supporting Lung Cancer Treatment—A Systematic Review

Omega-3 Memiliki Banyak Manfaat: Apakah Bisa Melawan Kanker?

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