Efficacy of Withania somnifera on lipid profile of endosulfan induced toxicity in Swiss albino mice

Abstract

India is an agrarian country with crops cultivated at a huge scale. Pesticides in recent times have caused serious health hazards in the population which are widely used by the farmers for the better yield of crops. Endosulfan is an organochlorine pesticide, which is widely used by the farmers. But, in the present times, it has caused serious health hazards in the exposed population causing various diseases, including cancer. Hence, the present study on animal aims to observe the protective effect of Withania somnifera against endosulfan induced toxicity in Swiss albino mice. Endosulfan at the dose of 3mg/Kg body weight per day was administered orally to Swiss albino mice for 4 weeks. Then after, W. somnifera at the dose of 1000 mg/Kg b.w. was orally administered for 4 weeks. Mice were sacrificed after the completion of the entire treatment. After dissection, the blood samples were collected for biochemical assay, especially for lipid profile analysis. The lipid profile study showed inclination in the Total cholesterol level (117±6.686 mg/dl), Cholesterol (LDL) (78.83±4.151mg/dl), level and Triglycerides level (60.83±2.613mg/dl), while declination in Cholesterol (HDL) (13.50±1.33mg/dl), level after Endosulfan exposure. But, upon W. somnifera treatment to the endosulfan treated group showed significant (p<0.001) normalisation in the lipid profile levels. Therefore, it was concluded that W. somnifera played a vital role to control the endosulfan induced toxicity.

Process optimisation for the development of giloy (Tinospora cordifolia L.) juice incorporated amla pulp candy

“…Grapes, pineapples, apples, cherries, strawberry, ginger, carrot, pumpkin, papaya, orange, lemon, mandarin, mangoes, gooseberry, and watermelon are some of the common fruits and vegetables being candied. Many researchers have undergone studies on different types of candies such as amla candy [1,24,50], carrot candy [14,44], ginger candy [2,[28][29], pumpkin candy [11,36], pineapple candy [9,23,25], citrus candy [17,33,42] and mango candy [26,31,38]. The incorporation of giloy juice or extract will increase the functional and therapeutic quality of all the above candies.…”