Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms

Al-Daghri, Nasser M.; Mohammed, Abdul Khader; Bukhari, Ihtisham; Rikli, Maryam; Abdi, Saba; Ansari, Mohammed Ghouse Ahmed; Sabico, Shaun; Hussain, Syed Danish; Alenad, Amal; Al‐Saleh, Yousef; Alokail, Majed S.

doi:10.1016/j.nut.2019.02.003

Cited by 46 publications

(43 citation statements)

References 29 publications

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“…However, few studies have comprehensively evaluated the effect of increasing vitamin D concentration on body composition 1 , and no studies have analyzed the associated gene expression. In addition, clinical studies with monozygotic twins (MZ) are molecular models that allow evaluation of phenotypic aspects with minor interference related to individual genetic variability 12 , 13 , since MZ twins come from the same zygote 14 . Thus, a gene expression study of vitamin D supplementation in this population is an innovative idea, since individual genetic variations influence serum levels of this micronutrient 15 , 16 .…”

Section: Introductionmentioning

confidence: 99%

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Medeiros

Borges

Soares

et al. 2020

Sci Rep

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Vitamin D supplementation is widely used. However, there is no consensus on the use and dosage of this supplement and the existing recommendations arise from studies based on the benefits that this nutrient can facilitate in bones. In addition, individual genetics can influence the response to supplementation, therefore, research involving monozygotic twins aims to reduce these differences in phenotypic responses. The objective of this randomised controlled study is to examine the effect of vitamin D supplementation on body composition and the expression of the vitamin D receptor (VDR) mRnA. An intervention was performed through supplementation with cholecalciferol at the concentration of 2000 IU in 90 healthy adult monozygotic twins (male or female pairs) for 2 months. The findings showed that serum vitamin D concentration increased by 65% and VDR gene expression sixty times (p = 0.001). Changes in body composition parameters were observed regarding body fat and lean mass. our results indicate that an increase in serum vitamin D concentration may have potential therapeutic implications. Supplementation with vitamin D (cholecalciferol) has become a widely used practice, since a relationship has been demonstrated of low levels of this nutrient with the increased risk of cardiovascular diseases, the recurrence of diseases, and mortality 1,2,3. However, as there is no consensus on sufficient serum levels of vitamin D, taking into account its non-skeletal functions, it is necessary to assess whether the increase in this nutrient in individuals with 25-hydroxyvitamin D (25 (OH) D) levels above the current cutoff point, generates any health benefits 4. Vitamin D is involved in several non-skeletal functions, such as cell regulation, differentiation, and growth 3 , and adaptive and innate immunity control 5 , as well as being associated with inflammatory markers 6 , since the vitamin D receptor (VDR) is expressed in almost all human cells 7. The activity of this nutrient in the human organism involves its binding with VDR 8 , whose expression is modulated by the blood levels of the 1,25diidroxivitamin D (1,25 (OH) 2D) 9 and genetic variants 10. It is believed that there is a negative correlation between the concentration of 25 (OH) D with the body mass index (BMI) and percentage of fat mass 11. However, few studies have comprehensively evaluated the effect of

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Section: Introductionmentioning

confidence: 99%

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Medeiros

Borges

Soares

et al. 2020

Sci Rep

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“…Evidence suggests that thiamine supplementation may rescue TPK enzyme activity. [ 119 ] Vitamin D GC 50,000 IU vitamin D3 per week for 8 weeks, followed by daily maintenance of 1000 IU vitamin D3 for 4 months 234 participants with vitamin D deficiency Carriers of GC mutation showed the lowest baseline 25(OH)D levels and lowest response to vitamin D supplementation. Mutations in GC gene can predict response to vitamin D supplementation.…”

Section: Resultsmentioning

confidence: 99%

Personalized Nutrition for Management of Micronutrient Deficiency—Literature Review in Non-bariatric Populations and Possible Utility in Bariatric Cohort

2020

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Background Bariatric surgery can effectively treat morbid obesity; however, micronutrient deficiencies are common despite recommendations for high-dose supplements. Genetic predisposition to deficiencies underscores necessary identification of high-risk candidates. Personalized nutrition (PN) can be a tool to manage these deficiencies. Methods Medline, PubMed, and Google Scholar were searched. Articles involving genetic testing, micronutrient metabolism, and bariatric surgery were included. Results Studies show associations between genetic variants and micronutrient metabolism. Research demonstrates genetic testing to be a predictor for outcomes among obesity and bariatric surgery populations. There is limited research in bariatric surgery and micronutrient genetic variants. Conclusion Genotype-based PN is becoming feasible to provide an effective treatment of micronutrient deficiencies associated with bariatric surgery. The role of genomic technology in micronutrient recommendations needs further investigation.

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“…Thus 42,43 Vitamin Dbinding protein or cytochrome P450 polymorphisms from differing genotypes may also have influenced the metabolic response to cholecalciferol therapy. [44][45][46] The mechanism(s) for the development of hypercalcemia during cholecalciferol supplementation in the absence of the classical definition of hypervitaminosis D in critically ill patients with severe traumatic injuries warrants further study. This study has limitations.…”

Section: Discussionmentioning

confidence: 99%

Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients

et al. 2019

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Background Vitamin D deficiency during critical illness has been associated with worsened outcomes. Because most critically ill patients with severe traumatic injuries are vitamin D deficient, we investigated the efficacy and safety of cholecalciferol therapy for these patients. Methods Fifty‐three patients (>17 years of age) admitted to the trauma intensive care unit who had a serum 25‐hydroxy vitamin D (25‐OH vit D) concentration <20 ng/mL were given 10,000 IU of cholecalciferol daily. Efficacy was defined as achievement of a 25‐OH vit D of 30–79.9 ng/mL. Safety was evaluated by the presence of hypercalcemia (serum ionized calcium [iCa] >1.32 mmol/L) or hypervitaminosis D (25‐OH vit D >79.9 nmol/L). Patients were monitored for 2 weeks during cholecalciferol therapy. Results: Twenty‐four patients (45%) achieved target 25‐OH vit D. No patients experienced hypervitaminosis D. Hypercalcemia occurred in 40% (n = 21) of patients; 2 patients experienced an iCa >1.49 nmol/L. 25‐OH vit D was significantly greater for those who developed hypercalcemia (37.2 + 11.2 vs 28.4 + 5.6 ng/mL, respectively, P < 0.001) by the second week of cholecalciferol. Of 24 patients who achieved target 25‐OH vit D, 14 (58%) experienced hypercalcemia in contrast to 24% of patients (7 out of 29) who did not achieve target 25‐OH vit D (P = 0.024). Conclusions Cholecalciferol normalized serum 25‐OH vit D concentrations in less than half of patients yet was associated with a substantial proportion of patients with hypercalcemia without hypervitaminosis D.

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Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms

Cited by 46 publications

References 29 publications

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

The impact of vitamin D supplementation on VDR gene expression and body composition in monozygotic twins: randomized controlled trial

Personalized Nutrition for Management of Micronutrient Deficiency—Literature Review in Non-bariatric Populations and Possible Utility in Bariatric Cohort

Hypercalcemia Without Hypervitaminosis D During Cholecalciferol Supplementation in Critically Ill Patients

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