Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

Suchonwanit, Poonkiat; Iamsumang, Wimolsiri; Rojhirunsakool, Salinee

doi:10.1007/s40257-018-0387-0

Cited by 48 publications

(50 citation statements)

References 18 publications

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“…AGA is a non-scarring alopecia in which terminal hairs transform into miniaturized hairs. Typically in men, baldness occurs with frontal recession and vertex thinning,26 while in women, hair loss is characterized by a decrease in hair density over the crown without frontal hairline involvement, also known as female pattern hair loss (FPHL) 27. Testosterone plays a role in AGA pathogenesis following conversion to dihydrotestosterone (DHT) by 5-alpha reductase 28,29…”

Section: Use Of Minoxidil In Hair Disordersmentioning

confidence: 99%

Minoxidil and its use in hair disorders: a review

Suchonwanit

Thammarucha

Leerunyakul

2019

DDDT

Self Cite

256

165

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Minoxidil was first introduced as an antihypertensive medication and the discovery of its common adverse event, hypertrichosis, led to the development of a topical formulation for promoting hair growth. To date, topical minoxidil is the mainstay treatment for androgenetic alopecia and is used as an off-label treatment for other hair loss conditions. Despite its widespread application, the exact mechanism of action of minoxidil is still not fully understood. In this article, we aim to review and update current information on the pharmacology, mechanism of action, clinical efficacy, and adverse events of topical minoxidil.

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Section: Use Of Minoxidil In Hair Disordersmentioning

confidence: 99%

Minoxidil and its use in hair disorders: a review

Suchonwanit

Thammarucha

Leerunyakul

2019

DDDT

Self Cite

256

165

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“…Several studies performed on Asians reported a lower prevalence of AGA and FPHL compared with the Europeans. [49][50][51][52] The development of AGA in Japanese men is approximately 10 years slower than that in Europeans, with 1.4-times lower in prevalence in each decade. 51 By contrast, the prevalence of AGA in Thais is higher and relatively similar to Caucasians, suggesting that the prevalence may be influenced by various genetic backgrounds.…”

Section: Non-scarring Alopecias In Asiansmentioning

confidence: 99%

Asian Hair: A Review of Structures, Properties, and Distinctive Disorders

Leerunyakul¹,

Suchonwanit²

2020

CCID

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Asian hair is known for its straightness, dark pigmentation, and large diameter. The cuticle layer in Asians is thicker with more compact cuticle cells than that in Caucasians. Asian hair generally exhibits the strongest mechanical properties, and its cross-sectional area is determined greatly by genetic variations, particularly from the ectodysplasin A receptor gene. However, knowledge on Asian hair remains unclear with limited studies. This article aimed to review and summarize the characteristics and properties of Asian hair. It also aimed to discuss hair disorders including linear lupus panniculitis and pseudocyst of the scalp that occur distinctively in Asian populations.

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“…Of the seven included studies, three 21,22,24 reported the clinical efficacy in terms of hair count increase, with a total of 99 patients. We used random effect model in analysis with high heterogeneity ( I 2 > 50%) among the three trials.…”

Section: Resultsmentioning

confidence: 99%

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

Zhou

Chen

et al. 2020

Dermatologic Therapy

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Androgenetic alopecia (AGA) is the most common type of baldness affecting both men and women. Studies investigating combination therapies for AGA reported greater efficacy than monotherapy but without rigorous examination. The authors performed a meta‐analysis and systemic review to further verify the evidence. To evaluate the effectiveness of three common combination therapies of minoxidil with finasteride, low‐level laser light therapy (LLLT) or microneedling versus minoxidil monotherapy. We conducted a systematic review of randomized controlled trials (RCTs) of combination therapies consisting of topical minoxidil for AGA through April 2020. Quality assessment and data analysis were performed by Review Manager 5.3. Fifteen studies met the inclusion criteria involving a total of 1172 AGA patients. We conducted meta‐analysis for three groups of combined treatment separately, and all were superior to monotherapy in terms of global photographic assessment (P < .05). Combination of LLLT or microneedling with minoxidil also showed significant increase in hair count (P < .05) compared to monotherapy. The present study suggests that combination therapy could be an effective, safe and promising option for the treatment of AGA. However, more RCTs are needed to further investigate and confirm the efficacy of combined treatment.

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Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

Abstract: clinicaltrials.in.th; identifier TCTR20160912002.

Cited by 48 publications

References 18 publications

<p>Minoxidil and its use in hair disorders: a review</p>

<p>Minoxidil and its use in hair disorders: a review</p>

<p>Asian Hair: A Review of Structures, Properties, and Distinctive Disorders</p>

The effectiveness of combination therapies for androgenetic alopecia: A systematic review and meta‐analysis

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