2010
DOI: 10.1055/s-0029-1186271 View full text |Buy / Rent full text
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Abstract: Pharmacological preconditioning with a new, potent non-adenosine analogue A1AdoR agonist improves biventricular function recovery and endothelial function after hypothermic cardiac arrest.

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“…In 4 animals without cardiopulmonary bypass the hearts were explanted and the coronary arteries were prepared for in vitro isolated vessel experiments (controls without cardiopulmonary bypass). 16 animals were used for the cardiopulmonary bypass studies, which were conducted according to our previously described experimental protocols [40; 41; 42]. All animals received humane care in compliance with the ”Principles of Laboratory Animal Care” formulated by the National Society for Medical Research and the ”Guide for the Care and Use of Laboratory Animals” prepared by the Institute of Laboratory Animal Resources and published by the National Institutes of Health (NIH Publication No.…”
Section: Methodsmentioning
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“…In 4 animals without cardiopulmonary bypass the hearts were explanted and the coronary arteries were prepared for in vitro isolated vessel experiments (controls without cardiopulmonary bypass). 16 animals were used for the cardiopulmonary bypass studies, which were conducted according to our previously described experimental protocols [40; 41; 42]. All animals received humane care in compliance with the ”Principles of Laboratory Animal Care” formulated by the National Society for Medical Research and the ”Guide for the Care and Use of Laboratory Animals” prepared by the Institute of Laboratory Animal Resources and published by the National Institutes of Health (NIH Publication No.…”
Section: Methodsmentioning
“…Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate (AMP) contents were assessed with standard photometry using an enzyme-kinetic assay [40; 41; 42]. …”
Section: Methodsmentioning
“…4) (Albrecht-K€ upper et al 2012). Furthermore, it has been shown that pharmacological preconditioning with a non-adenosine analogue A1R agonist improves cardiac function recovery as well as endothelial function after cardiopulmonary bypass surgery in dogs (Veres et al 2010). In a study by Yao et al, stimulation of myocardial A1Rs was cardioprotective during repetitive and brief periods of coronary artery occlusion in anesthetized dogs (Yao and Gross 1993).…”
Section: Preconditioning and Cardioprotectionmentioning
“…Adenosine and its primary metabolite inosine are ubiquitous nucleosides that can be released from ischemic or reperfused tissue [2]. Adenosine and adenosine analogues have been shown to act as an endogenous cardio-protective agent against ischemia-reperfusion injury [3,4]. Until recently, inosine was generally considered an inactive metabolite.…”
Section: Introductionmentioning