Efficacy of Superovulation and Intrauterine Insemination in the Treatment of Infertility

Abstract

Among infertile couples, treatment with induction of superovulation and intrauterine insemination is three times as likely to result in pregnancy as is intracervical insemination and twice as likely to result in pregnancy as is treatment with either superovulation and intracervical insemination or intrauterine insemination alone.

Intrauterine insemination in natural cycle may give better results in older women

“…In theory the probability of conception can be further improved by increasing the number of available oocytes at the site of fertilization, hence the role of COH. Controlled ovarian hyper-stimulation in combination with intrauterine insemination has been shown to result in significantly higher pregnancy rate when compared to un-stimulated (natural cycle) IUI [1,5]. Our data is consistent with these studies, but only among younger women.…”

“…Controlled ovarian hyper-stimulation (COH) in combination with intrauterine insemination (IUI) has been shown to result in significantly higher pregnancy rate compared to unstimulated (natural cycle) IUI [1]. However a meta-analysis of 4 trials including 479 completed cycles found no significant difference between IUI in cycles with COH and IUI in natural cycle [2].…”

The reproductive performance of women with hypogonadotropic hypogonadism in an in vitro fertilization and embryo transfer program

“…The addition of intrauterine insemination to exogenous gonadotropin treatment has been shown to increase the efficacy of infertility treatment in patients with unexplained and male factor infertility (25)(26)(27). Conceivably, following gonadotropin administration, IUI can be considered for women with HH.…”

Intrauterine insemination: is the timing correct?

“…Based on this finding, IUI has been traditionally performed around post-hCG 36th hour. Guzick et al have reported 33% pregnancy rate when IUI was performed between 36-40 h after hCG injection [5]. Two hCG-IUI intervals, 33 versus 39 h, was compared in a prospective, randomised clinical trial [6].…”