Biochemical Pharmacology volume 79, issue 4, P535-541 2010 DOI: 10.1016/j.bcp.2009.09.012 View full text
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Valentina Zuco, Rosanna Supino, Enrica Favini, Monica Tortoreto, Raffaella Cincinelli, Anna Cleta Croce, Federica Bucci, Claudio Pisano, Franco Zunino

Abstract: AbstractST1968 (namitecan), a novel 7-modified hydrophilic camptothecin, was found to be effective against tumor models relatively resistant to topotecan and irinotecan. Based on this observation, this study was designed to investigate the cellular and antitumor effects of ST1968 in a subline of A431, squamous cell carcinoma, selected for resistance to topotecan (A431/TPT). This model was characterized by a slow growth rate, associated with down-regulation of EGFR and topoisomerase I. In contrast to other cam…

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