Efficacy of Psychostimulant Drugs for Cocaine Dependence

The effectiveness of compulsory drug treatment: A systematic review

“…62–66 We also note that this is likely the case in settings seeking to control the harms of non-opioid substance use disorders such as cocaine use disorder, given that available interventions that have been shown to be effective have been undertaken using voluntary treatment approaches. 11,12,16 Governments seeking to implement or bring to scale harm reduction interventions that include OST and needle and syringe distribution will therefore likely be required to reduce their reliance on compulsory and law enforcement-based approaches in order to ensure treatment effectiveness.…”

The effectiveness of compulsory drug treatment: A systematic review

“…62–66 We also note that this is likely the case in settings seeking to control the harms of non-opioid substance use disorders such as cocaine use disorder, given that available interventions that have been shown to be effective have been undertaken using voluntary treatment approaches. 11,12,16 Governments seeking to implement or bring to scale harm reduction interventions that include OST and needle and syringe distribution will therefore likely be required to reduce their reliance on compulsory and law enforcement-based approaches in order to ensure treatment effectiveness.…”

Treatment of substance abusing patients with comorbid psychiatric disorders

“…Interestingly, the antidepressant buproprion was found to be among two others, dextroamphetamine and modafinil, in showing a trend for increasing cocaine abstinence. It should be noted that none of the medications investigated had an effect on decreasing cocaine use but there was a statistical trend showing that more patients receiving medication achieved cocaine abstinence compared to those receiving placebo (Castells et al, 2010). Castells and colleagues (2009) also reviewed the findings on cocaine use among patients on opioid replacement therapies and found that higher doses of methadone were more effective for retaining patients in treatment and for their achieving abstinence from heroin.…”

Psychotic Symptoms Associated with the use of Dopaminergic Drugs, in Patients with Cocaine Dependence or Abuse

“…Finally, as a limitation of this study, it should be pointed out that other stimulants have been proposed for the treatment of cocaine-dependent patients and there are some hopeful results that encourage further research with these drugs, mainly with dextro-amphetamine [8, 65]. Recent clinical trials carried out with extended release amphetamines in cocaine abusers [66] or cocaine-dependent patients [67] should be mentioned.…”

The effectiveness of compulsory drug treatment: A systematic review

“…62–66 We also note that this is likely the case in settings seeking to control the harms of non-opioid substance use disorders such as cocaine use disorder, given that available interventions that have been shown to be effective have been undertaken using voluntary treatment approaches. 11,12,16 Governments seeking to implement or bring to scale harm reduction interventions that include OST and needle and syringe distribution will therefore likely be required to reduce their reliance on compulsory and law enforcement-based approaches in order to ensure treatment effectiveness.…”

Treatment of substance abusing patients with comorbid psychiatric disorders

“…Interestingly, the antidepressant buproprion was found to be among two others, dextroamphetamine and modafinil, in showing a trend for increasing cocaine abstinence. It should be noted that none of the medications investigated had an effect on decreasing cocaine use but there was a statistical trend showing that more patients receiving medication achieved cocaine abstinence compared to those receiving placebo (Castells et al, 2010). Castells and colleagues (2009) also reviewed the findings on cocaine use among patients on opioid replacement therapies and found that higher doses of methadone were more effective for retaining patients in treatment and for their achieving abstinence from heroin.…”

Psychotic Symptoms Associated with the use of Dopaminergic Drugs, in Patients with Cocaine Dependence or Abuse

“…Finally, as a limitation of this study, it should be pointed out that other stimulants have been proposed for the treatment of cocaine-dependent patients and there are some hopeful results that encourage further research with these drugs, mainly with dextro-amphetamine [8, 65]. Recent clinical trials carried out with extended release amphetamines in cocaine abusers [66] or cocaine-dependent patients [67] should be mentioned.…”

The effectiveness of compulsory drug treatment: A systematic review

“…62–66 We also note that this is likely the case in settings seeking to control the harms of non-opioid substance use disorders such as cocaine use disorder, given that available interventions that have been shown to be effective have been undertaken using voluntary treatment approaches. 11,12,16 Governments seeking to implement or bring to scale harm reduction interventions that include OST and needle and syringe distribution will therefore likely be required to reduce their reliance on compulsory and law enforcement-based approaches in order to ensure treatment effectiveness.…”

Treatment of substance abusing patients with comorbid psychiatric disorders

“…Interestingly, the antidepressant buproprion was found to be among two others, dextroamphetamine and modafinil, in showing a trend for increasing cocaine abstinence. It should be noted that none of the medications investigated had an effect on decreasing cocaine use but there was a statistical trend showing that more patients receiving medication achieved cocaine abstinence compared to those receiving placebo (Castells et al, 2010). Castells and colleagues (2009) also reviewed the findings on cocaine use among patients on opioid replacement therapies and found that higher doses of methadone were more effective for retaining patients in treatment and for their achieving abstinence from heroin.…”

Psychotic Symptoms Associated with the use of Dopaminergic Drugs, in Patients with Cocaine Dependence or Abuse

“…Finally, as a limitation of this study, it should be pointed out that other stimulants have been proposed for the treatment of cocaine-dependent patients and there are some hopeful results that encourage further research with these drugs, mainly with dextro-amphetamine [8, 65]. Recent clinical trials carried out with extended release amphetamines in cocaine abusers [66] or cocaine-dependent patients [67] should be mentioned.…”