Efficacy of Probiotics in Prevention of Influenza

Miyazaki, Tatsuya

doi:10.1007/978-3-319-23213-3_6

Cited by 3 publications

(3 citation statements)

References 52 publications

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“…For instance, the intake of Lactobacillus gasseri SBT2055 increased hemagglutination- inhibition titers against influenza viruses (IFVs) after vaccination as compared to the intake of placebo by healthy volunteers ( Nishihira et al, 2016 ). SBT2055 was found to effectively protect against influenza A virus infection by suppressing viral replication through induction of the expression of antiviral genes in mice ( Nakayama et al, 2014 ; Miyazaki, 2015 ). Oral administration of Lactobacillus brevis KB290 to mice also alleviates clinical symptoms following influenza virus infection by the enhancement of IFN-α production and augmentation of IFV-specific IgA production ( Waki et al, 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

et al. 2018

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We recently reported that Lactobacillus helveticus SBT2171 (LH2171) inhibited the proliferation and inflammatory cytokine production of primary immune cells in vitro, and alleviated collagen-induced arthritis (CIA) in mice, a model of human rheumatoid arthritis (RA). In this study, we newly investigated whether LH2171 could relieve the severity of experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS), which is an autoimmune disease, but develop the symptoms by different mechanisms from RA. In MS and EAE, main cause of the disease is the abnormality in CD4+ T cell immunity, whereas in RA and CIA, is that in antibody-mediated immunity. The intraperitoneal administration of LH2171 significantly decreased the incidence and clinical score of EAE in mice. LH2171 also reduced the numbers of pathogenic immune cells, especially Th17 cells, in the spinal cord at the peak stage of disease severity. Interestingly, before the onset of EAE, LH2171 administration remarkably decreased the ratio of Th17 cells to CD4+ T cells in the inguinal lymph nodes (LNs), where pathogenic immune cells are activated to infiltrate the central nervous system, including the spinal cord. Furthermore, the expression of interleukin (IL)-6, an inflammatory cytokine essential for Th17 differentiation, decreased in the LNs of LH2171-administered mice. Moreover, LH2171 significantly inhibited IL-6 production in vitro from both DC2.4 and RAW264.7 cells, model cell lines of antigen-presenting cells. These findings suggest that LH2171 might down-regulate IL-6 production and the subsequent Th17 differentiation and spinal cord infiltration, consequently alleviating EAE symptoms.

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Section: Introductionmentioning

confidence: 99%

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

et al. 2018

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“…According to the definition of FAO/WHO, probiotics are living microorganisms that, when administered in adequate amounts, have beneficial health effects for the host. Numerous beneficial effects have been identified for probiotics, which improve the host's health status by improving the intestinal environment and affecting the immune system function (Miyazaki 2015;Nishihira et al 2016). Several studies reported that probiotics might be able to help to prevent and treat a wide range of allergic and chronic ADs (Gill and Guarner 2004;Tlaskalová-Hogenová et al 2004), particularly managing the severity of EAE (Kobayashi et al 2010;Lavasani et al 2010;Takata et al 2011;Kwon et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

Valizadeh

Seghinsara

Chollou³

et al. 2021

Lett Appl Microbiol

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Crosstalk between COVID-19 and the gut-brain axis: a gut feeling

Kalam,

Balasubramaniam

2024

Postgraduate Medical Journal

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The microbes in the gut are crucial for maintaining the body’s immune system and overall gut health. However, it is not fully understood how an unstable gut environment can lead to more severe cases of SARS-CoV-2 infection. The gut microbiota also plays a role in the gut-brain axis and interacts with the central nervous system through metabolic and neuroendocrine pathways. The interaction between the microbiota and the host’s body involves hormonal, immune, and neural pathways, and any disruption in the balance of gut bacteria can lead to dysbiosis, which contributes to pathogen growth. In this context, we discuss how dysbiosis could contribute to comorbidities that increase susceptibility to SARS-CoV-2. Probiotics and fecal microbiota transplantation have successfully treated infectious and non-infectious inflammatory-related diseases, the most common comorbidities. These treatments could be adjuvant therapies for COVID-19 infection by restoring gut homeostasis and balancing the gut microbiota.

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Efficacy of Probiotics in Prevention of Influenza

Cited by 3 publications

References 52 publications

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

Lactobacillus helveticus SBT2171 Attenuates Experimental Autoimmune Encephalomyelitis in Mice

The efficacy of probiotics in experimental autoimmune encephalomyelitis (an animal model for MS): a systematic review and meta‐analysis

Crosstalk between COVID-19 and the gut-brain axis: a gut feeling

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