Efficacy of Probiotics-Based Interventions as Therapy for Inflammatory Bowel Disease: A Recent Update

Selvamani, Shanmugaprakasham; Mehta, Vijay; Enshasy, Hesham Ali El; Thevarajoo, Suganthi; Adawi, Hala El; Zeini, Ibrahim Mamdouh; Pham, Khoa Ta; Varzakas, Theodoros; Abomoelak, Bassam

doi:10.1016/j.sjbs.2022.02.044

Cited by 27 publications

(20 citation statements)

References 130 publications

(451 reference statements)

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“…Hence, the development of new therapies and the discovery of alternative strategies targeting microbial dysbiosis are needed in the management of UC. Probiotics have been applied in the management of the disease to modify the gut microbiota, improve intestinal barrier integrity and function, and maintain a balanced immune response [ 9 ]. Nevertheless, conventional probiotics do not always provide the expected health benefits to the patient, so next-generation probiotics (NGP), fecal microbiota transplantation (FMT), and postbiotics therapies targeting dysbiosis in UC have been developed recently.…”

Section: Introductionmentioning

confidence: 99%

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

et al. 2022

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Although there are number of available therapies for ulcerative colitis (UC), many patients are unresponsive to these treatments or experience secondary failure during treatment. Thus, the development of new therapies or alternative strategies with minimal side effects is inevitable. Strategies targeting dysbiosis of gut microbiota have been tested in the management of UC due to the unquestionable role of gut microbiota in the etiology of UC. Advanced molecular analyses of gut microbiomes revealed evident dysbiosis in UC patients, characterized by a reduced biodiversity of commensal microbiota. Administration of conventional probiotic strains is a commonly applied approach in the management of the disease to modify the gut microbiome, improve intestinal barrier integrity and function, and maintain a balanced immune response. However, conventional probiotics do not always provide the expected health benefits to a patient. Their benefits vary significantly, depending on the type and stage of the disease and the strain and dose of the probiotics administered. Their mechanism of action is also strain-dependent. Recently, new candidates for potential next-generation probiotics have been discovered. This could bring to light new approaches in the restoration of microbiome homeostasis and in UC treatment in a targeted manner. The aim of this paper is to provide an updated review on the current options of probiotic-based therapies, highlight the effective conventional probiotic strains, and outline the future possibilities of next-generation probiotic and postbiotic supplementation and fecal microbiota transplantation in the management of UC.

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Section: Introductionmentioning

confidence: 99%

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

et al. 2022

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“…Regarding the anti-in ammatory and immunoregulatory function of probiotics they have been considered as a new frontier in prevention and management of UC (15,28). It has been demonstrated that probiotic therapy signi cantly alleviate the clinical symptoms of UC by downregulating expression levels of proin ammatory cytokines including IL-6, IL-1 and TNF-α while increasing levels of antiin ammatory markers and metabolites (12,29). In line with this, Tanaka and colleagues showed that levels of in ammatory cytokines such as IL-6, IL-12 and TNF-α were reduced in orally administered 06CC2 group while the expression of IL-10 was notably increased (30).…”

Section: Probiotics Modulates Fibrosis In Colitis Mice Modelmentioning

confidence: 99%

“…According to the de nition of the World Health Organization (WHO), probiotics are living micro-organisms which, when administered in adequate amounts, confer a health bene t on the host. Regarding their proven health bene ts they have been applied in the management of several disease including gastrointestinal disorders like UC (9)(10)(11)(12)(13). Several protective mechanisms have been de ned for probiotics including improvement of intestinal barrier function, secretion of anti-in ammatory and anti-oxidant metabolites, regulation of tissue brosis, alteration of gut microbial composition, and modulation of immune responses (14,15).…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory and Ameliorative effects of two newly isolated probiotic strains in DSS-induced mouse model of colitis

Ghorbani

Rezaei

Soleimanpour

et al. 2023

Preprint

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Background: Protective effects of probiotics in human diseases have been well documented in recent years. In this study, the anti-inflammatory and fibrinolytic properties of two newly isolated probiotic bacteria, Lactiplantibacillus plantarum and Lactococcus lactis either alone or in combination with standard therapy, Mesalazine (MSZ), have been investigated in a murine model for ulcerative colitis. Methods: Characterization of newly isolated probiotic were assessed by performing antibacterial activity, antibiotic resistance, acid and bile tolerance, and hemolytic activity assays. Hematoxylin-Eosin and Masson's trichrome staining were used to evaluate inflammation and collagen deposition in colon tissue sections. Expression of inflammatory- and Fibrotic-associated genes were analyzed using Real-time PCR and ELISA assays. Results: Results showed that administration of probiotics significantly attenuated DSS-induced colon shortening, colon weight loss, and increase in spleen weight in colitis mice. Compared to the colitis mice, disease activity index as assessed by changes in body weight, degree of stool consistency, rectal bleeding, and prolapse was decreased in probiotic-treated group. Mix of probiotics potently improved histopathological score by attenuating crypt loss, mucosal damage, and inflammation score in colitis tissues. Consistently, mRNA and protein levels of pro-inflammatory genes as well as oxidative stress markers were suppressed in the presence of probiotics in colon tissues. Furthermore, probiotic bacteria reduced fibrosis by down-regulating pro-fibrotic genes including Col 1a1 and α-SMA in colon tissue homogenates. Conclusion: These results showed that mix of these newly isolated probiotic bacteria is as potent as the standard treatment and could be utilize as a novel therapy for ulcerative colitis without any observed side effects. Future experiments on these probiotics in other models of UC is needed to completely address the efficacy potency and safety concerns.

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“…6 GM can be manipulated by supplementing live beneficial microorganisms, i.e., probiotics, compounds facilitating the growth and activity of probiotics, i.e., prebiotics, or ''a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host,'' i.e., synbiotics. [7][8][9] Dietary fibres are not digestible in the gastrointestinal (GI) tract and not directly bioactive. 3 However, dietary fibres, especially soluble ones, can be fermented by GM in the colon, and the metabolites contribute to gut health.…”

Section: Introductionmentioning

confidence: 99%

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

Zhong,

Reyes-Jurado,

Calumba

2024

Soft Matter

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Efficacy of Probiotics-Based Interventions as Therapy for Inflammatory Bowel Disease: A Recent Update

Cited by 27 publications

References 130 publications

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

Anti-inflammatory and Ameliorative effects of two newly isolated probiotic strains in DSS-induced mouse model of colitis

Structured soft particulate matters for delivery of bioactive compounds in foods and functioning in the colon

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