Efficacy of Primary Tumor Resection in Metastatic Colorectal Cancer

Abstract

Background The aim of this study was to evaluate the survival benefit of palliative primary tumor resection in colorectal cancer (CRC) patients with unresectable metastases. Material/Methods Clinicopathological characteristics of eligible patients who underwent surgery to remove the primary tumor and those who did not between 2004 and 2013 were compared. We also evaluated the association between survival and different clinicopathologic characteristics in metastatic CRC. Results The percentage of patients undergoing surgical resection of the primary tumor was higher during the earlier years and trended toward less use of surgery in later years. Palliative primary tumor resection was strongly associated with better cause-specific survival (hazard ratio=0.403, 95% confidence interval=0.389 to 0.417, P <0.001). Conclusions We added new strong evidence supporting the survival benefit of palliative resection, which should be confirmed in future randomized controlled trials.

Palliative primary tumor resection in minimally symptomatic patients with colorectal cancer and synchronous unresectable metastases: when is it necessary? (systematic review)

“…ПР была выполнена 66% пациентам [1]. Однако доля пациентов, перенесших данное оперативное вмешательство, в последующие годы снизилась и на 2013 год составила 45,9% [17]. В отсутствии убедительной доказательной базы на смену старой парадигмы пришла новая, согласно которой ПР в настоящее Оправданы ли паллиативные резекции ободочной и прямой кишки при малосимптомной первичной опухоли и синхронных нерезектабельных метастазах колоректального рака?…”