Efficacy of pentoxifylline in prevention of contrast-induced nephropathy in angioplasty patients

Firouzi, Ata; Eshraghi, Ali; Shakerian, Farshad; Sanati, Hamid Reza; Salehi, Negar; Zahedmehr, Ali; Kiani, Reza; Madani, Mohsen; Pedarzadeh, Ali

doi:10.1007/s11255-011-0053-4

Cited by 25 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Em relação à N-acetilcisteína, apesar de ser estudada há bastante tempo, os dados são conflitantes quanto ao seu poder de prevenção da NIC pós-coronariografia. 17 Pentoxifilina não se mostrou protetora para ocorrência de NIC em amostras de baixo risco (coronariografia eletiva), 18,19 faltando ainda dados em pacientes submetidos à coronariografia de urgência. Em metanálise recente, fenoldopam intravenoso não foi superior à salina ou N-acetilcisteína.…”

Section: Resultsunclassified

Contrast-induced nephropathy after primary angioplasty for acute myocardial infarction

Santos¹,

Neto²,

Arcanjo³

et al. 2015

Jornal Brasileiro De Nefrologia

View full text Add to dashboard Cite

Nefropatia induzida por contraste após angioplastia primária no infarto agudo do miocárdio Contrast-induced nephropathy after primary angioplasty for acute myocardial infarctionIntrodução: A prevenção da nefropatia induzida por contraste (NIC) é difícil nas situações de emergência, tornando essenciais estudos sobre NIC em pacientes submetidos à angioplastia de urgência. Objetivo: Determinar a incidência e fatores associados à NIC em pacientes com infarto agudo do miocárdio (IAM) submetidos à angioplastia nas primeiras 12 horas após início dos sintomas. Métodos: Foram estudados 201 casos consecutivos de IAM com supradesnivelamento do segmento ST com menos de 12 horas de evolução. Todos os pacientes foram submetidos ao mesmo protocolo de angioplastia. A NIC foi definida como elevação absoluta da creatinina de pelo menos 0,5 mg/dL e/ou aumento relativo da creatinina de 25% em relação ao valor basal no período entre 48 e 72 horas após a administração do contraste. As variáveis que diferiram entre os pacientes com e sem NIC na análise univariada foram analisadas por regressão logística. Resultados: A amostra foi formada por 135 (67,2%) homens e 66 (32,8%) mulheres com idade média de 66,6 ± 11,7 anos. A incidência de NIC foi de 23,8%. Na análise univariada os pacientes com NIC eram mais idosos e com maior frequência de fração de ejeção do ventrículo esquerdo ≤ 40% e da classificação Killip ≥ 2. Na análise multivariada não foram encontrados preditores independentes de NIC. Conclusão: A NIC acomete ¼ dos pacientes com IAM submetidos à angioplastia sem variáveis preditoras. Esse resultado ressalta a necessidade de medidas preventivas para NIC após uso de contraste em angioplastia de urgência. ResumoPalavras-chave: angioplastia coronária com balão; infarto do miocárdio; lesão renal aguda; meios de contraste. Introduction:The prevention of contrastinduced nephropathy (CIN) is difficult in emergency situations, making it essential to study CIN in patients submitted to urgent angioplasty. Objective: To determine the incidence and associated factors to CIN in patients with myocardial infarction (MI) submitted to primary angioplasty in the first 12 hours after onset of symptoms. Methods: We studied 201 consecutive cases of MI with ST-segment elevation with less than 12 hours of evolution. All patients were submitted to the same angioplasty protocol. CIN was defined as an absolute increase of creatinine of at least 0.5 mg/ dL and/or a relative increase of creatinine of 25% in relation to baseline in a period between 48 and 72 hours after contrast administration. The variables that differed between patients with and without CIN in univariate analysis were analyzed by logistic regression. Results: The sample was formed by 135 (67.2%) men and 66 (32.8%) women, with mean age of 66.6 ± 11.7 years. The incidence of CIN was 23.8%. In univariate analysis the patients with CIN were older and had higher frequency of left ventricular ejection fraction ≤ 40% and Killip classification ≥ 2. In multivariate analysis, we did not find independe...

show abstract

Section: Resultsunclassified

Contrast-induced nephropathy after primary angioplasty for acute myocardial infarction

Santos¹,

Neto²,

Arcanjo³

et al. 2015

Jornal Brasileiro De Nefrologia

View full text Add to dashboard Cite

show abstract

“…To prevent CIAKI, many therapeutic strategies aimed at different pathological mechanisms have been implemented; however, the role of different strategies is still controversial . Therapeutic modalities mainly include risk factor modification, hydration, diuresis, tubular alkalization, vasodilators, anti‐inflammatory and antioxidant agents, and adjustment of contrast medium volume and osmolality . Vitamin E is a lipid‐soluble vitamin with antioxidative and anti‐inflammatory properties in the form of α‐tocopherol, which has been found to be effective in the prevention and treatment of cardiovascular complications and cancer .…”

Section: Introductionmentioning

confidence: 99%

Short‐Term High‐Dose Vitamin E to Prevent Contrast Medium–Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo‐Controlled Trial

Rezaei

Khademvatani

Rahimi

et al. 2016

JAHA

View full text Add to dashboard Cite

show abstract

“…accounted as the third cause of hospital-acquired acute renal failure (2,3). CIN occurs in more than 15% of patients undergoing cardiac catheterization (4).…”

Section: Introductionmentioning

confidence: 99%

“…Yet, the exact pathophysiological mechanism of CIN is not well understood. Alteration of renal hemodynamics or direct toxic effects of contrast media on tubular cells may be responsible (2). Enhanced formation of Reactive Oxygen Species (ROS) in kidney following contrast media exposure may also play a central role in this pathology (5).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Oral Selenium: Can It Prevent Contrast-Induced Nephropathy Following Coronary Angiography and Angioplasty

Sani¹,

Kharat²,

Vejdanparast³

et al. 2015

Int Cardiovasc Res J

Self Cite

View full text Add to dashboard Cite

A B S T R A C TBackground: Alteration of kidney function called Contrast-Induced Nephropathy (CIN) is commonly encountered in diagnostic and interventional cardiology procedures. It results in considerable morbidity and mortality besides imposing significant costs on the healthcare system. Today, it is accounted as the third cause of hospital-acquired acute renal failure. Objectives: Considering anti-oxidant and free radical scavenging properties of selenium and the role of free radicals in CIN, the present study aimed to investigate the effects of oral selenium (in the form of Se-yeast capsule) on preventing or decreasing the rate of CIN in patients undergoing angiography and angioplasty. Patients and Methods: This prospective, non-randomized, single-blind, single-center clinical trial was conducted on 175 consecutive patients admitted for elective coronary angiography (N = 105) or angioplasty (N = 70). Selenium was prescribed as a single dose of 200 micrograms the day before and after the procedure. Routine hydration based on the ward protocol was administered for all the patients. For the control group, the researchers made use of the data of another survey performed in the same hospitals for determining the prevalence of CIN a year before. The data were analyzed using student's t-test and logistic regression analysis and P < 0.05 was considered as statistically significant. Results: Based on the results of student's t-test, the mean difference between the two groups was significant only in hematocrit levels. The incidence of CIN was 9% in the selenium group compared to 22% in the control group (P = 0.027). There was no case of in-hospital mortality and none of the CIN patients required renal replacement therapy during hospitalization. Conclusions: Prophylactic selenium administration may significantly reduce the incidence of CIN.

show abstract

Efficacy of pentoxifylline in prevention of contrast-induced nephropathy in angioplasty patients

Abstract: In angioplasty patients, the prophylactic oral use of PTX could be recommended for CIN prevention, although no statistically significant protective effect was documented.

Cited by 25 publications

References 17 publications

Contrast-induced nephropathy after primary angioplasty for acute myocardial infarction

Contrast-induced nephropathy after primary angioplasty for acute myocardial infarction

Short‐Term High‐Dose Vitamin E to Prevent Contrast Medium–Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo‐Controlled Trial

Oral Selenium: Can It Prevent Contrast-Induced Nephropathy Following Coronary Angiography and Angioplasty

Contact Info

Product

Resources

About