Efficacy of Ozone and Selenium Therapy for Alcoholic Liver Injury: An Experimental Model

Abstract

Background/Aim: Alcoholic liver disease is an important health problem which is reversible during early stages of liver damage, but becomes permanent with time. Nowadays, many studies focus on various agents that prevent, reduce or slow the progression of the toxic effects of alcohol. In our study, we investigated the efficiency of ozone and selenium against oxidative damage in a model of alcohol-induced liver damage. Materials and Methods: Forty-eight female Wistar Albino rats between 4 and 6 months of age and weighing 190-250 g were included in the study and were used as models of alcohol liver damage. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), serum and tissue total oxidant levels, serum and tissue total antioxidant levels, and the histopathological evaluation of the liver were performed in 8 groups. Results: In the statistical analysis, it was observed that ozone and/or selenium therapies decreased the AST levels. Total oxidant and antioxidant serum levels were found to vary in serum and tissue. Ozone and/or selenium therapies decreased liver damage, according to histopathological findings. Conclusion: Through ozone and/or selenium therapies, less damage was observed histopathologically compared to the alcohol group. It is thought that the results of our study can be used in individual treatments following confirmation of liver damage in alcoholic patients.

Potential Cytoprotective Activity of Ozone Therapy in SARS-CoV-2/COVID-19

“…OT stabilizes hepatic metabolism and tend to normalize fibrinogen and prothrombin plasma levels in infected patients, suggesting an improvement of the hepatic protein synthesis [15]. There is extensive research demonstrating the cytoprotective effect of ozone to prevent oxidative damage to the heart [44,45], liver [46,47], lungs [48] and renal tissues [49]. The authors have described in a recent review, the cytoprotective effect of ozone to prevent and even to treat chemotherapy-induced damage in heart, liver, renal and lung tissue [22].…”

Ozone vs Melatonin: The Therapeutic Effects In Alcoholic Liver Disease

“…Besides, the only-melatonin treated group had similar effects with the only-ozone treated group. As to the literature, melatonin and ozone applications led to a histopathological recovery in the toxicity groups (8,18,20,26,27).…”

“…Although several studies are evaluating the effects of some agents, drugs or chemicals on liver damage (23), limited publications are assessing the effects on liver morphology (25,26). The damage that alcohol causes is characterized by vacuolar hepatic cell degeneration, microvesicular steatosis, and periportal inflammation.…”

A Review on SARS-CoV-2-Induced Neuroinflammation, Neurodevelopmental Complications, and Recent Updates on the Vaccine Development

“…Furthermore, this therapy can stabilize the plasma levels in viral-infected patients by improving hepatic protein synthesis [248]. It could also exert a cytoprotective effect by preventing oxidative damage to the heart [249,250], liver [251,252], and renal tissues [253]. Systemic OT has the capacity to modulate the expression of the NF-κB/Nrf2 pathway and IL-6/IL-1β pathway consequently foster cytoprotection by blocking viral replication [245].…”