Efficacy of oleuropein against UVB irradiation: preliminary evaluation

Perugini, Paola; Vettor, Manuela Teresa; Rona, Claudia; Troisi, Luigino; Villanova, Luciano; Genta, Ida; Conti, Bice; Pavanetto, F

doi:10.1111/j.1468-2494.2008.00424.x

Cited by 42 publications

(32 citation statements)

References 21 publications

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“…The same observations were found by Perugini et al. ; no major differences were observed between moisturizers preserved by BHT and those preserved by 0.5% of plant phenolic extracts in cosmetic formulations.…”

Section: Resultssupporting

confidence: 88%

“…Due to the beneficial properties of these natural compounds, the use of olive extracts as raw material in the manufacture of cosmetic products is an interesting way of innovation for cosmetic industries . Oleuropein, known to possess several biological properties many of which may be attributed to its antioxidant activity, seems to be very effective in preventing skin photoageing . HyT and Ty can be recovered from olive oil wastewaters .…”

Section: Introductionmentioning

confidence: 99%

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Valorization of antioxidants extracted from olive mill wastewater

Aissa

Kharrat

Aloui

et al. 2017

Biotech and App Biochem

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Antioxidants are highly important gradients used to preserve cosmetic products and reduce the effect of oxidative stress on the skin. The present work explores the possibility of using phenolic compounds of olive mill wastewater (OMW) as effective alternatives to the commercial antioxidants used in cosmetic formulations deemed by their allergic and carcinogenic effects. Esterification of tyrosol and hydroxytyrosol extracted from OMW with various fatty acids was conducted using Novozyme 435 lipase as a biocatalyst. Upon synthesis, butyrate, caprate, laurate, and palmitate tyrosyl and hydroxytyrosyl esters were isolated and evaluated for their antioxidant and antibacterial activities. Results showed that laurate derivatives are the most efficient in preventing lipid oxidation and inhibiting growth of pathogenic strains. In the prospective of industrial use, laurate tyrosyl and hydroxytyrosyl derivatives were incorporated in a formulation of moisturizer to substitute the commercial antioxidant butylated hydroxyltoluene. Oleuropein, extracted from olive leaves powder, was also tested as an antiaging ingredient in cosmetic formulations. The evaluation of physicochemical, microbiological, and sensorial properties of the new cosmetic products indicated that oleuropein and lipophilic derivatives do not affect the properties of the standard formulation. Oleuropein and lipophilic derivatives can be added as active ingredients to stabilize cosmetic preparations.

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Section: Resultssupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Valorization of antioxidants extracted from olive mill wastewater

Aissa

Kharrat

Aloui

et al. 2017

Biotech and App Biochem

View full text Add to dashboard Cite

show abstract

“…This corroborates earlier case‐control and population‐based observations of a consistent trend towards lower risk of melanoma and SCC with higher levels of dietary n‐3 PUFAs 106 and elevated n‐3:n‐6 PUFA ratios 107 . Further, olive oil yields the phenolic antioxidants hydroxytyrosol and oleuropein, which have been shown to be protective against UVR‐induced carcinogenic cellular activity 108–110 …”

Section: Skin‐protective Mechanisms Of Nutrientssupporting

confidence: 88%

Nutritional approach to sun protection: a suggested complement to external strategies

Shapira¹

2010

Nutrition Reviews

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The increasing incidence of skin cancer despite the use of externally applied sun protection strategies, alongside research showing that nutrients reduce photo-oxidative damage, suggest nutritional approaches could play a beneficial role in skin cancer prevention. Penetrating photo-oxidative ultraviolet A radiation reduces skin and blood antioxidants and damages cell components, including DNA. Dietary antioxidant vitamins, minerals, and phytochemicals in addition to n-3 polyunsaturated fatty acids, n-9 monounsaturated fatty acids, and low pro-inflammatory n-6 polyunsaturated fatty acids, have demonstrated protective properties. The presence of these elements in the traditional Greek-style Mediterranean diet may have contributed to the low rates of melanoma in the Mediterranean region despite high levels of solar radiation. This suggests a potentially relevant model for studying dietary/nutritional supplementation for lifelong internal support of sun-protection mechanisms, which could complement external strategies.

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“…Thus, we suggest that olive oil‐induced reductions in ROS production may attenuate MMP‐2 expression through the inhibition of ERK 1/2 and c‐JUN pathway‐induced reduction in collagen fibre breakdown in ex vivo stressed human skin. This hypothesis is reinforced by previous studies where polyphenols (such as hydroxytyrosol and oleuropein) contained in olive oil protect human skin against UV radiation‐induced damage . Hydroxytyrosol administration reduces intracellular ROS generation, cellular apoptosis and DNA oxidative damage in human skin keratinocytes exposed to UVB radiation .…”

Section: Discussionmentioning

confidence: 70%

Olive oil inhibits ageing signs induced by chronic stress in ex vivo human skin via inhibition of extracellular‐signal‐related kinase 1/2 and c‐JUN pathways

Romana‐Souza

Monte‐Alto‐Costa

2019

Intern J of Cosmetic Sci

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Objective Chronic stress‐induced oxidative damage and protease synthesis cause a loss of extracellular matrix components promoting human skin ageing. The administration of antioxidant compounds, such as those observed in olive oil, may attenuate stress‐induced ageing signs in human skin. Thus, the aim of this study was to investigate the effect of olive oil administration in ex vivo stressed human skin. Methods Explants of human skin were treated with high levels of epinephrine (as observed in stressed patients) and olive oil in medium for 13 days. Cultures treated with medium alone were used as controls. Results Olive oil reversed the high epinephrine level‐induced reduction in epidermis and dermis thickness and collagen fibre content in ex vivo human skin. The increase in the production of reactive oxygen species (ROS) and malondialdehyde levels (an index of lipid peroxidation) promoted by high levels of epinephrine were also attenuated by olive oil in ex vivo human skin. Moreover, olive oil was able to reverse the high epinephrine level‐induced increase in extracellular signal‐related kinase 1/2 (ERK 1/2) and c‐JUN (a major component of transcription factor AP‐1) phosphorylation and protein matrix metalloproteinase‐2 (MMP‐2) expression in ex vivo human skin. Conclusion Olive oil attenuates stress‐induced ageing signs (thinner dermis and collagen fibre loss) in ex vivo human skin by reducing MMP‐2 expression, ROS production, and ERK 1/2 and c‐JUN phosphorylation.

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Efficacy of oleuropein against UVB irradiation: preliminary evaluation

Cited by 42 publications

References 21 publications

Valorization of antioxidants extracted from olive mill wastewater

Valorization of antioxidants extracted from olive mill wastewater

Nutritional approach to sun protection: a suggested complement to external strategies

Olive oil inhibits ageing signs induced by chronic stress in ex vivo human skin via inhibition of extracellular‐signal‐related kinase 1/2 and c‐JUN pathways

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