Efficacy of Monensin for the Prevention of Subclinical Ketosis in Lactating Dairy Cows

Duffield, T.F.; Sandals, D.; Leslie, K.E.; Lissemore, K.; McBride, B.W.; Lumsden, J. H.; Dick, P.; Bagg, R.

doi:10.3168/jds.s0022-0302(98)75846-1

Cited by 199 publications

(183 citation statements)

References 22 publications

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“…However, a similar high incidence of subclinical ketosis was reported by Duffield et al (1998) in which a lower blood BHBA cut-off value at >1200 mmol/l was used.…”

supporting

confidence: 60%

“…Incidence of subclinical ketosis was calculated as the proportion of cows that had plasma BHBA concentration >1400 mmol/l (Duffield et al, 1998;Carrier et al, 2004) at the time of blood sampling. The percentage of cows that experienced single episode of subclinical ketosis was calculated as the proportion of cows that had plasma BHBA concentration >1400 mmol/l at one sampling time point.…”

Section: Calculationsmentioning

confidence: 99%

“…The level of plasma BHBA at >1400 mmol/l was used as the cut-off value for diagnosis of subclinical ketosis in this experiment (Duffield et al, 1998;Carrier et al, 2004). Supplementation of PG tended (P 5 0.07) to decrease the overall mean incidence of subclinical ketosis from 39% to 24% to 13% for cows not supplemented with PG, cows supplemented with PG by top dressing it onto the TMR, and cows supplemented with PG by incorporating it into the TMR, respectively (Table 8).…”

mentioning

confidence: 99%

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Effects of feeding dry propylene glycol to early postpartum Holstein dairy cows on production and blood parameters

Chung

Girard²,

Varga

2009

Animal

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In all, 18 multiparous and 19 primiparous Holstein dairy cows were used in a completely randomized design with restrictions to evaluate the effects of feeding propylene glycol (PG) as a dry product, via two delivery methods, on production and blood parameters. PG treatments were administered from parturition through 21 days postpartum. Treatments were: (i) control, no PG; (ii) top dress, 162.5 g PG/day by top dressing onto the total mixed ration (TMR) and; (iii) mixing, 162.5 g PG/day as a part of the TMR by incorporating it into the TMR. PG used was a dry product which contained 65% pure PG and 35% silicon dioxide as the dry carrier. Coccygeal blood was sampled on 4, 7, 14 and 21 days in milk (61.50 pooled s.d.). Supplementation of dry PG by top dressing onto, or incorporating into, the TMR had no effects on average dry matter intake, milk yield and composition, serum insulin, serum and plasma metabolites and milk ketones. Concentrations of urine ketones tended (P 5 0.10) to be reduced by PG supplementation from 41.5 to 15.2 mg/dl. Supplementation of PG tended ( P 5 0.07) to decrease the incidence for subclinical ketosis from 39% to 24% and 13% for cows fed a TMR supplemented with no dry PG, with dry PG as a top dress and dry PG as a part of the TMR, respectively. It is concluded that supplementing PG as a dry product via incorporating into the TMR is as effective as when used as a top dress, based on the efficacies of both delivery methods to numerically reduce urine ketones concentrations and, therefore, the incidence for subclinical ketosis during the first 21 days of lactation. However, it should be noted that the number of cows used in the current study was minimal, and more cows are needed to confirm the efficacy of supplementing PG as a dry product on reducing the prevalence of subclinical ketosis in dairy cows during the first month of lactation.

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“…However, a similar high incidence of subclinical ketosis was reported by Duffield et al (1998) in which a lower blood BHBA cut-off value at >1200 mmol/l was used.…”

supporting

confidence: 60%

Section: Calculationsmentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of feeding dry propylene glycol to early postpartum Holstein dairy cows on production and blood parameters

Chung

Girard²,

Varga

2009

Animal

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“…Maximal blood levels in healthy cows are 0.48 mM for acetoacetate and 0.85 mM for D-b-hydroxybutyrate [2]. However, a mean level over 1.0 mM for both ketones [3] or for D-b-hydroxybutyrate alone [4,5] is considered, in practice, to be the top limit of normality in the cow. This value is below the concentration required to sustain bovine embryo development in vitro [1].…”

Section: Introductionmentioning

confidence: 99%

Effects of acetoacetate and d-β-hydroxybutyrate on bovine in vitro embryo development in serum-free medium

Gómez¹,

Duque²,

Dı́az³

et al. 2002

Theriogenology

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It is known that the ketone bodies acetoacetate and D-b-hydroxybutyrate can be metabolized by the early bovine embryo for in vitro development. In the present work, we report experiments leading to the culture of bovine embryos in the absence of serum. In vitro-produced bovine zygotes were cultured in modi®ed synthetic oviduct¯uid medium supplemented with acetoacetate derivatives, acetoacetate and D-b-hydroxybutyrate. Acetoacetate and its derivatives prevented blastocysts from forming in the absence of serum during the whole culture period. However, from Days 6 to 8 of culture in the absence of serum, acetoacetate did not affect development as compared to controls containing lactate and pyruvate or no substrate. Interestingly, D-b-hydroxybutyrate stimulated blastocyst and expansion development, and allowed lipid mobilization. In feeder cells coculture, embryos produced with D-b-hydroxybutyrate showed improved hatching. Embryos cultured in D-bhydroxybutyrate were viable upon transfer to recipients, although no pregnancies were con®rmed later by ultrasonic scanning. The protective effect of serum upon embryos cultured in medium containing acetoacetate is apparently not required in the presence of D-b-hydroxybutyrate. #

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“…Duffield et al (1998aDuffield et al ( , 1998bDuffield et al ( , 1999 demonstraram o potencial de administração de monensina através de cápsulas de liberação lenta (335 mg/dia de monensina por 95 dias) para vacas no pré-parto. Em um experimento que contou com mais de 1000 vacas e novilhas estes autores observaram redução nas concentrações de betahidroxibutirato (BHBA) e aumento nas concentrações de glicose e uréia plasmática com a administração do ionóforo.…”

Section: Introdução Geralunclassified

Desempenho produtivo e resíduos no leite de vacas suplementadas com monensina sódica nas rações

Santos¹

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Agradeço, primeiramente a Deus, por tornar possível meus sonhos.Agradeço a minha família, por me apoiarem e incentivarem. Pela sabedoria a que me guiaram e continuam guiando pelos caminhos da vida, sempre me ensinando o discernimento e conduzindo para caminhos certos. À empresa Tortuga pela concessão do auxílio à pesquisa que resultou na realização deste estudo.Ao meu orientador Prof. Dr. Francisco Palma Rennó, pela oportunidade de realização deste estudo, pela confiança em minha capacidade, pela sabedoria e ensinamentos. Pela competência, orientação, profissionalismo, paciência e dedicação. Por todas as conversas e críticas que foram muito produtivas em minha vida. Reconheço hoje o quanto cresci pessoalmente e profissionalmente e muito disso devo ao meu orientador, por ter me apoiado quando precisei e ter me repreendido quando estava errada. Afinal, errando é que se aprende e agradeço muito a oportunidade de ter feito parte de sua equipe.Ao Carlinhos, por todos os ensinamentos e ajuda indispensável para a realização do estudo.As grandes amigas Beatriz (Bixuka) e Ana Paula, por todo o companheirismo, dedicação, paciência, apoio e amizade. Por todas as horas de conversas, risadas, desabafos, desesperos e de alegrias. Obrigada por você fazer parte da minha vida. A vida nos tornou amigas e o coração nos tornou irmãs.Ao José Esler, por tornar possível esse estudo e suas análises. Pela ajuda e dedicação que foi imprescindível. Pelas horas de conselhos e conversas. Por ter se tornado um amigo tão especial.À amiga Esther por toda a paciência e amizade. Por ter me recebido tão bem aqui e sempre ter me ajudado.À amiga Lenita por todas as horas de conversa e conselhos, por sempre me apoiar e ajudar.À Cybele e Gabriella por em tão pouco tempo de convivência terem se tornado pessoas tão importantes em minha vida, sempre me apoiando e me ajudando. Houve efeito linear decrescente do consumo de matéria seca, matéria orgânica, proteína bruta, extrato etéreo, carboidratos totais, fibra detergente neutro, carboidratos não fibrosos e nutrientes digestíveis totais. Não houve diferença na digestibilidade aparente total da matéria seca e dos nutrientes em função das rações experimentais, excetuando-se a digestibilidade aparente total da proteína bruta e fibra detergente neutro, que foram observados efeitos linear crescente e decrescente, respectivamente. Não houve efeito das rações experimentais sobre os valores de pH ruminal. A suplementação com monensina sódica nas dietas resultou em alteração da proporção molar de propionato no líquido ruminal, além de diminuir a relação acetato:propionato. As rações contendo monensina sódica apresentaram maior proporção molar de propionato e menor de acetato em relação à ração controle, e, de forma semelhante, apresentaram menor relação acetato:propionato. Não houve efeito das dietas experimentais nas excreções diárias totais de urina, de alantoína e de acido úrico na urina, e de derivados de purinas totais. Não houve diferença na porcentagem de alantoína nos derivados de purina, das purinas abso...

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Efficacy of Monensin for the Prevention of Subclinical Ketosis in Lactating Dairy Cows

Cited by 199 publications

References 22 publications

Effects of feeding dry propylene glycol to early postpartum Holstein dairy cows on production and blood parameters

Effects of feeding dry propylene glycol to early postpartum Holstein dairy cows on production and blood parameters

Effects of acetoacetate and d-β-hydroxybutyrate on bovine in vitro embryo development in serum-free medium

Desempenho produtivo e resíduos no leite de vacas suplementadas com monensina sódica nas rações

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