Efficacy of mifepristone – Prostaglandin analogue combination in medical termination of pregnancy up to and beyond 7 weeks of amenorrhea: The RYMMa study.

Evaluation of Pain and Use of Analgesics during Medical Termination of Pregnancy in Real-Life Settings

“…All women were given a curative analgesic prescription (CAP) to be used at their discretion. Data including demographic data, obstetrical history including history of previous ToPs, confirmation of pregnancy and MToP therapeutic protocol were collected during this visit [16].…”

“…The second visit was scheduled between 2 and 3 weeks after inclusion to assess MToP success (complete expulsion) as recommended in guidelines in place during the inclusion period [2]. Complementary data, such as intrauterine surgical procedures, additional misoprostol intake and tolerance, were recorded during this visit [16].…”

“…the follow-up visit, 398 (53.1%) women had an API (that was prescribed or not) including 386 (73.7%) who had an APP and 12 (5.3%) who had no APP (Table 1). Demographic data and obstetrical history including history of previous ToPs were described in the previous publication [16] and were described for each group. Except for the MToP protocol, no particular differences in women characteristics were observed (Supplementary Tables S1 and S2).…”

“…In this context, contemporary data on pain management in MToP remain inconsistent, notably regarding the place of analgesics prophylaxis and the pain level experienced by women, the factors related to pain onset and the use of curative analgesic treatment [14,15]. Recently, we reported a high rate of success for MToP using mifepristone 600 mg, independent of the pregnancy term and the therapeutic protocol used [16]. We present here the prespecified evaluation of pain resulting from the MToP procedure using a fixed dose of antiprogestin and the modality of pain management in real-life settings in France.…”