Efficacy of melatonin and hyaluronate/carboxymethylcellulose membrane in preventing adhesion reformation following adhesiolysis in a rat uterine model

Abstract

Melatonin and HA/CMC membrane are both effective separately in preventing adhesion reformation following adhesiolysis, but in combination they are significantly more beneficial.

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

“…In our study, it was used the effect of flunixin meglumine 1.1 mg/kg on the postoperative adhesions and HA/CMC covered on the peritoneal defect. These results, as expected under guidance of previous result of the studies [7,10,11,[14][15][16][17][18] , have supported that both HA/CMC and flunixin meglumine decreases adhesion formation, as evaluated by the scoring of adhesion, fibrosis, and inflammatory compared with the control group (P<0.05), (Table 1). …”

“…So that based on this results, it was concluded that they were effective in combination rather than the separate using. The result of HA/CMC and flunixin meglumine combination in this study was paralel to those of other combination [8,9,18,23,26] .…”

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

“…In our study, it was used the effect of flunixin meglumine 1.1 mg/kg on the postoperative adhesions and HA/CMC covered on the peritoneal defect. These results, as expected under guidance of previous result of the studies [7,10,11,[14][15][16][17][18] , have supported that both HA/CMC and flunixin meglumine decreases adhesion formation, as evaluated by the scoring of adhesion, fibrosis, and inflammatory compared with the control group (P<0.05), (Table 1). …”

“…So that based on this results, it was concluded that they were effective in combination rather than the separate using. The result of HA/CMC and flunixin meglumine combination in this study was paralel to those of other combination [8,9,18,23,26] .…”

Surgery-Induced Changes in Erythrocyte and Plasma Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidants of Female Rats: Protective Role of Heparin and Pentoxifylline

“…Vitamin E also inhibits the synthesis of thromboxane and prostaglandin with its inhibition effect on arachidonic acid metabolism, in which free oxygen radicals are so effective. Inhibition of thromboxane, a potent thrombocyte-aggre-gating factor, reduces the amount of fibroblasts by inhibiting thrombus formation and prevents adhesion formation by inhibiting fibrin formation [11,27,52]. Because of this effect, it is thought that the reason for the decrease of vitamin E in the control group compared to the other groups is due to the usage during the occurence of this effect.…”

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

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Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

“…In our study, it was used the effect of flunixin meglumine 1.1 mg/kg on the postoperative adhesions and HA/CMC covered on the peritoneal defect. These results, as expected under guidance of previous result of the studies [7,10,11,[14][15][16][17][18] , have supported that both HA/CMC and flunixin meglumine decreases adhesion formation, as evaluated by the scoring of adhesion, fibrosis, and inflammatory compared with the control group (P<0.05), (Table 1). …”

“…So that based on this results, it was concluded that they were effective in combination rather than the separate using. The result of HA/CMC and flunixin meglumine combination in this study was paralel to those of other combination [8,9,18,23,26] .…”

Surgery-Induced Changes in Erythrocyte and Plasma Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidants of Female Rats: Protective Role of Heparin and Pentoxifylline

“…Vitamin E also inhibits the synthesis of thromboxane and prostaglandin with its inhibition effect on arachidonic acid metabolism, in which free oxygen radicals are so effective. Inhibition of thromboxane, a potent thrombocyte-aggre-gating factor, reduces the amount of fibroblasts by inhibiting thrombus formation and prevents adhesion formation by inhibiting fibrin formation [11,27,52]. Because of this effect, it is thought that the reason for the decrease of vitamin E in the control group compared to the other groups is due to the usage during the occurence of this effect.…”

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

“……”

“……”

Effect of Hyaluronic Acid/Carboxymethylcellulose and Flunixin Meglumine Combination on the Prevention of Postoperative Intraabdominal Adhesions: An Experimental Study in Rabbits

“…In our study, it was used the effect of flunixin meglumine 1.1 mg/kg on the postoperative adhesions and HA/CMC covered on the peritoneal defect. These results, as expected under guidance of previous result of the studies [7,10,11,[14][15][16][17][18] , have supported that both HA/CMC and flunixin meglumine decreases adhesion formation, as evaluated by the scoring of adhesion, fibrosis, and inflammatory compared with the control group (P<0.05), (Table 1). …”

“…So that based on this results, it was concluded that they were effective in combination rather than the separate using. The result of HA/CMC and flunixin meglumine combination in this study was paralel to those of other combination [8,9,18,23,26] .…”

Surgery-Induced Changes in Erythrocyte and Plasma Lipid Peroxidation, Enzymatic and Non-Enzymatic Antioxidants of Female Rats: Protective Role of Heparin and Pentoxifylline

“…Vitamin E also inhibits the synthesis of thromboxane and prostaglandin with its inhibition effect on arachidonic acid metabolism, in which free oxygen radicals are so effective. Inhibition of thromboxane, a potent thrombocyte-aggre-gating factor, reduces the amount of fibroblasts by inhibiting thrombus formation and prevents adhesion formation by inhibiting fibrin formation [11,27,52]. Because of this effect, it is thought that the reason for the decrease of vitamin E in the control group compared to the other groups is due to the usage during the occurence of this effect.…”

Hyaluronate acid and oxidized regenerated cellulose prevent adhesion reformation after adhesiolysis in rat models

“……”

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