Efficacy of low-level laser therapy for the treatment of burning mouth syndrome: a randomized, controlled trial

Abstract

The aim of the present study was to assess the effect of low-level laser therapy (LLLT) in the treatment of burning mouth syndrome (BMS). A diode laser was used in 78 BMS patients who were randomly assigned into four groups: IR1W, n = 20 (830 nm, 100 mW, 5 J, 176 J/cm2, 50 s, LLLT weekly sessions, 10 sessions); IR3W, n = 20 (830 nm, 100 mW, 5 J, 176 J/cm2, 50 s, three LLLT weekly sessions, 9 sessions); red laser, n = 19 (685 nm, 35 mW, 2 J, 72 J/cm2, 58 s, three LLLT weekly sessions, 9 sessions); and control-group (CG), n = 19. Symptoms were assessed at the end of the treatment and eight weeks later; quality of life related to oral health was assessed using the Oral Health Impact Profile (OHIP-14). Statistical analysis was carried out using repeated measures analysis of variance followed by the posthoc Tukey test. There was significant reduction of the symptoms in all groups at the end of the treatment, which was maintained in the follow-up. The scores of the IR1W and IR3W laser groups differed significantly from those of the CG. There was also a decrease in the OHIP-14 scores in the four groups. The IR3W laser group scores differed significantly from those of the CG. LLLT reduces the symptoms of BMS and may be an alternative therapeutic strategy for the relief of symptoms in patients with BMS.

Effects of low‐level laser therapy on burning mouth syndrome

“…Like Spanemberg et al . , the present study noted considerable differences in methodology among the various studies in this field: some have lacked control groups or have had inadequate sample sizes; the laser treatments applied varied greatly (number of applications, duration, wavelength and frequency characteristics) which points to a lack of treatment standardisation. Further randomised clinical trials are need that pay close attention to subjects’ group assignation.…”

Low‐level laser therapy 810‐nm up‐regulates macrophage secretion of neurotrophic factors via PKA‐CREB and promotes neuronal axon regeneration in vitro

“…17 In In contrast, this study used LLLT, which is a widely clinically used noninvasive therapy that can suppress inflammation and promote recovery. 20 Early studies have already discovered that LLLT can increase the production of IL-4 and IL-10 within the lesion site, down-regulate the relative abundance of M1 macrophages and increase the number of M2 macrophages. 12 To confirm the direct effect of LLLT on the regulation of M1 macrophages, we have innovatively established an in vitro LLLT-M1 macrophage irradiation model.…”

World Workshop on Oral Medicine VII: Burning mouth syndrome: A systematic review of disease definitions and diagnostic criteria utilized in randomized clinical trials

“…In this systematic review, nearly 75% of the RCTs used an existing BMS definition to guide case selection (Cavalcanti & da Silveira, ; Femiano, ; Femiano & Scully, ; Gremeau‐Richard, Dubray, Aublet‐Cuvelier, Ughetto, & Woda, ; Gremeau‐Richard et al., ; Lopez‐Jornet, Camacho‐Alonso, & Andujar‐Mateos, ; Marino, Torretta, Capaccio, Pignataro, & Spadari, ; Petruzzi, Lauritano, De Benedittis, Baldoni, & Serpico, ; Sardella et al., , ; Spanemberg, Lopez Lopez, de Figueiredo, Cherubini, & Salum, ; Spanemberg et al., ), most commonly that by IASP (Cano‐Carrillo, Pons‐Fuster, & Lopez‐Jornet, ; Cavalcanti & da Silveira, ; Gremeau‐Richard et al., ; Jorgensen & Pedersen, ; Lopez‐Jornet et al., ; Marino et al., ; Palacios‐Sánchez, Moreno‐Lopez, Cerero‐Lapiedra, Llamas‐Martinez, & Esparza‐Gomez, ; Sardella et al., ; Silva, Siqueira, Teixeira, & Siqueira, ; Spanemberg et al., ; Umezaki et al., ) or IHS (Arduino et al., ; Carbone, Pentenero, Carrozzo, Ippolito, & Gandolfo, ; Jurisic Kvesic et al., ; Lopez‐Jornet, Camacho‐Alonso, & Leon‐Espinosa, ; López‐Jornet, Camacho‐Alonso, & Molino‐Pagan, ; Tammiala‐Salonen & Forssell, ; Valenzuela & Lopez‐Jornet, ; Valenzuela, Pons‐Fuster, & Lopez‐Jornet, ). However, the most current BMS definition by IASP and IHS differs (IASP, ; IHS, ).…”

“…Author Aublet-Cuvelier, Ughetto, & Woda, 2010;Gremeau-Richard et al, 2004;Lopez-Jornet, Camacho-Alonso, & Andujar-Mateos, 2011;Marino, Torretta, Capaccio, Pignataro, & Spadari, 2010;Petruzzi, Lauritano, De Benedittis, Baldoni, & Serpico, 2004;Sardella et al, 1999Sardella et al, , 2008Spanemberg, Lopez Lopez, de Figueiredo, Cherubini, & Salum, 2015;Spanemberg et al, 2012), most commonly that by IASP (Cano-Carrillo,…”