2022
DOI: 10.3390/jcm11041093
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Abstract: (1) Introduction: Intraoperative preservation solutions for saphenous vein grafts may influence the endothelial structure and increase the risk of graft failure after coronary surgery. The aim of the study was to compare the efficacy of three solutions in maintaining the endothelial cell integrity of venous segments. (2) Methods: We tested the efficacy of physiological saline solution (PSS), heparinized autologous blood (HAB) and DuraGraft® in preserving the endothelium of vein segments by evaluating the degre… Show more

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Cited by 2 publications
(2 citation statements)
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References 23 publications
(28 reference statements)
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“…The PREVENT IV trial identified that in 2,817 patients who underwent CABG, veins stored in saline or blood-based solutions demonstrated a higher rate of failure at one year compared to buffered saline (5). Previously suggested reasons for saline being harmful to endothelium include its lack of ionic balance, and its acidic pH (5.5) (8).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…The PREVENT IV trial identified that in 2,817 patients who underwent CABG, veins stored in saline or blood-based solutions demonstrated a higher rate of failure at one year compared to buffered saline (5). Previously suggested reasons for saline being harmful to endothelium include its lack of ionic balance, and its acidic pH (5.5) (8).…”
Section: Discussionmentioning
confidence: 99%
“…Thrombosis is the major cause of early graft failure (9). Whilst thrombogenicity in this setting is highly multifactorial, endothelial injury of the conduit arguably plays an important role, and intraoperative storage solutions influence this process (5,8,10). Structurally, the endothelial surface layer is defined as the endothelial cellular glycocalyx, which is a layer of glycans lining all human cells, and its associated plasma proteins (11-13).…”
Section: Discussionmentioning
confidence: 99%