Efficacy of Intensive Phototherapy as A Treatment Modality for Neonatal Hyperbilirubinemia

Hamed, Amira Mohammed Mohammed; Younis, Mohammed M. S.; Mohammed, Said Mostafa Al-Sayed

doi:10.21608/ejhm.2020.105924

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Phototherapy works by the principle of photoisomerization, which lowers the bilirubin level by breaking down bilirubin. The bilirubin photoisomerization mainly transpires in the skin layers, and it takes about one to three hours to restore the bilirubin levels in the skin [7][8] . Therefore, a long off and on follow-up may not be as operative as continuous therapy, but a shorter on and off sequence of <1 hr.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Intermittent vs. Continuous Phototherapy in the treatment of Non-Haemolytic Neonatal Hyperbilirubinemia

Ullah¹,

Khan²,

Kazemi³

et al. 2022

PJMHS

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Introduction: Phototherapy is used in the treatment of hyperbilirubinemia in initial life-span of neonates. Our objective was the comparison of continuous vs intermittent phototherapy in the reduction of total serum bilirubin, bilirubin decrease rate, phototherapy time and hospital stay in non-haemolytic hyperbilirubinemia neonates. Place and Duration: The study was conducted at department of Pediatric medicine in Qazi Hussain Ahmad Medical Complex, Nowshera for the duration of six months from 16th January 2021 to 15th July 2021. Methods: The study involved 160 neonates with birth weight ≥2000 gm and age was above 34 weeks. They were randomly assigned to group A who were given continuous phototherapy for 3hrs and 50 mints and then rest for 45mints and group B who were given intermittent phototherapy for 3 hours and then rest for next 3 hours and so on. The levels of TSB were calculated in both groups and their comparison was made at every 12, 24 and 48 hrs after the start of phototherapy. Results: The mean of total serum bilirubin on admission was 16.01 ± 3.91 mg / dL for the continuous group and 15.21 ± 1.12 mg / dL for the intermittent group. The TSB mean after 12, 24 and 48 hrs. for continuous phototherapy was 13.30 ± 2.3 mg / dl, 11.1 ± 2.01 mg / dl, 9.26 ± 0.92 mg / dl and 13.1 ± 1.70 mg / dL, 9.54 ± 1.7 mg / dL, 8.9 ± 0.61 mg / dl (p <0.05) for the intermittent group, respectively. The mean rate of decrease in serum concentration of bilirubin was 0.30 ± 0.14 mg / dl / h in group A and 0.19 ± 0.07 mg / dl / h in group B (p = 0.5). There was no big variance between the mean hospital stay in groups A and B (p = 0.550). Conclusions: Intermittent phototherapy is a better choice than continuous phototherapy in the treatment of non-haemolytic hyperbilirubinemia, with added benefits such as less frequent disruption of the mother-child relationship and reduced radiation therapy. Keywords: Intermittent phototherapy; Continuous phototherapy; Total serum bilirubin and Neonatal hyperbilirubinemia.

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Section: Introductionmentioning

confidence: 99%

Comparison of Intermittent vs. Continuous Phototherapy in the treatment of Non-Haemolytic Neonatal Hyperbilirubinemia

Ullah¹,

Khan²,

Kazemi³

et al. 2022

PJMHS

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“…El estudio comparativode Pawar & Nandimalla (2020) demostró que el uso de fototerapia intensiva (mayor irradiación) en lugar de la convencional reduce la necesidad de exanguinotransfusión, mostrando este método menos invasivo como una alternativa a la exanguinotransfusión. Apoyando esto, el estudio deHamed et al, (2020) concluyo que la fototerapia intensiva es tan eficaz como la exanguinotransfusión, para tratar la hiperbilirrubinemia patológica reduciendo la bilirrubina seria toral y consigo las complicaciones del a exanguinotransfusión. Y finalmenteAbe & Fujioka (2021) en su estudio empelaron fototerapia con doble led…”

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Fototerapia y Exanguinotransfusión como Tratamiento en Neonatos con Hiperbilirrubinemia. Revisión sistemática

Mena Toapanta,

Cusme Torres

2024

Reincisol

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La hiperbilirrubinemia, un aumento en los niveles de bilirrubina en recién nacidos, puede causar complicaciones graves como encefalopatía y daño neurológico si no se trata adecuadamente. La fototerapia y la exanguinotransfusión son terapias comunes, pero su eficacia y riesgos se deben gestionar con cuidados de enfermería especializados basados en la evidencia. El objetivo es evaluar el uso de fototerapia y exanguinotransfusión como tratamiento en neonatos con hiperbilirrubinemia. Metodología: se trata de una revisión sistemática de carácter cualitativo, mediante una búsqueda exhaustiva de artículos científicos en las diferentes bases de datos como: Scopus, Scielo, Pubmed, Google académico. Así también como la selección de los mismos a través del método PRISMA. Se finalizó con 16 artículos que aportan la información más relevante y de carácter científica sobre la fototerapia y exanguinotransfusión como tratamiento para la hiperbilirrubinemia neonatal. Se puede emplear como tratamiento de la hiperbilirrubinemia neonatal tanto la fototerapia como exanguinotransfusión. La elección se basa en la gravedad que presente el recién nacido, teniendo en cuenta también la seguridad y respuesta del neonato a los tratamientos iniciales y la necesidad de empelar tratamiento de mayor complejidad e invasivos.

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Impact of phototherapy type and duration on serum electrolytes and blood glucose in neonatal hyperbilirubinemia: a prospective single-center cohort study

Tosson

Abdel-Razek

Yossif

et al. 2022

Egypt Pediatric Association Gaz

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Background Neonatal hyperbilirubinemia (NH) is among the common neonatal morbidities. Phototherapy is its most used therapeutic intervention. Different delivering systems and types are currently available. This study aimed to detect and compare the effects of the different phototherapy types on serum electrolytes and blood glucose and to study the effect of phototherapy duration on them. Results Five hundred healthy newborns with indirect NH were treated by different phototherapy types (conventional, light emitting diode LED, intensive) according to severity and availability. Serum sodium (Na), potassium (K), calcium (Ca), blood urea nitrogen (BUN), creatinine (Cr), and blood glucose (Glu) were measured repeatedly over 48 h of phototherapy. In this prospective cohort study, 273 (54.6%) neonates were exposed to conventional phototherapy, 145 (29.0%) to LED, and 82 (16.4%) to intensive phototherapy. A highly significant negative correlation was found between phototherapy duration and serum levels of Na, K, Ca, BUN, and Cr (p < 0.001). There was a positive correlation between phototherapy duration and blood glucose level (p = 0.005). Each type of phototherapy individually significantly affected the Na, K, Bun, Cr, and Ca levels after 48 h. Comparing the effects of the 3 different phototherapy types together, no significant differences apart from a decline in potassium level at 48 h (p = 0.043) were recorded. Conclusions Serum electrolytes significantly decreased during phototherapy. These changes were affected by the phototherapy duration. The type of phototherapy had only some effect on serum potassium.

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Efficacy of Intensive Phototherapy as A Treatment Modality for Neonatal Hyperbilirubinemia

Cited by 3 publications

References 6 publications

Comparison of Intermittent vs. Continuous Phototherapy in the treatment of Non-Haemolytic Neonatal Hyperbilirubinemia

Comparison of Intermittent vs. Continuous Phototherapy in the treatment of Non-Haemolytic Neonatal Hyperbilirubinemia

Fototerapia y Exanguinotransfusión como Tratamiento en Neonatos con Hiperbilirrubinemia. Revisión sistemática

Impact of phototherapy type and duration on serum electrolytes and blood glucose in neonatal hyperbilirubinemia: a prospective single-center cohort study

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