Efficacy of Infliximab in Rheumatoid Arthritis: A Relationship to the Total Dose of the Drug

Аронова, Е. С.; Lukina, G.; Сигидин, Я А

doi:10.14412/1995-4484-2015-506-511

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“…по результатам анализа 9 крупных регистров больных РА, получающих ГИБТ, выявили достоверную взаимосвязь между наличием аутоантител (РФ и антитела к циклическому цитруллинированному пептиду) и удовлетворительной эффективностью АБА [25]. Также мы ранее сообщали о выявленной корреляции между удовлетворительной эффективностью ИНФ и РФ-негативным РА [26]. Таким образом, необходимы дополнительные исследования взаимосвязи между клинико-иммунологическим профилем РА и продолжительностью ГИБТ.…”

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Survival of bDMARDs in bionaive patients with rheumatoid arthritis: data from a retrospective 12-month follow-up

Аронова

Lukina

Глухова

et al. 2020

Terapevticheskii arkhiv

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Aim. Analysis of survival on biological therapy in previously bionaive patients with rheumatoid arthritis (RA) during the first year of therapy in real clinical practice. Materials and methods. The retrospective study included 204 adult patients with RA. In the hospital, patients were first prescribed therapy with various biological disease-modifying antirheumatic drugs (bDMARDs): infliximab, adalimumab, etanercept, certolizumab pegol, tocilizumab, abatacept (ABA), rituximab (RTM). Patients were divided by age in accordance with the classification adopted by WHO. Clinical forms of RA were presented: RA, seropositive for rheumatoid factor, RA, seronegative for rheumatoid factor, RA with extra-articular manifestations, adult-oneset Stills disease, juvenile RA. The reasons for the cancellation of bDMARD during the first year of treatment were: insufficient effectiveness (including primary inefficiency), adverse events, administrative reasons, clinical and laboratory remission, death. Results. A year after being included in the study, treatment was continued in 92 (45%) patients and was discontinued in 112 patients. The average time of treatment amounted to 0.750.33 years. The longest duration of treatment was in the RTM and ABA groups (0.920.22 and 0.830.29 years, respectively). In 56 (50%) patients, bDMARD was canceled due to insufficient effectiveness (including primary inefficiency), 28 patients (25%) due to the development of adverse reactions, 19 (17%) patients for administrative reasons, 7 (6.25%) patients due to drug remission. During the first year of therapy, there were 2 (1.75%) deaths due to severe comorbid conditions in patients, one of whom received RTM, the other tocilizumab. Conclusion. Study showed that 45% of patients with RA continue treatment with first-time bDMARD for more than 12 months. The most common reason for discontinuation of therapy was its lack of effectiveness. The best survival rate of bDMARDs was observed in RTM and ABA. When selecting bDMARD in each case, it is necessary to take into account the continuity at all stages of treatment.

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