Efficacy of growth factors for the treatment of peri-implant diseases: a systematic review and meta-analysis

Khouly, Ismael; Pardiñas-López, Simon; Ruff, Ryan Richard; Strauß, Franz Josef

doi:10.1007/s00784-020-03240-5

Cited by 6 publications

(9 citation statements)

References 71 publications

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“…Many studies have already assessed the efficacy of probiotics in preventing caries, gingivitis, cancer therapy-induced oral mucositis, periodontitis, and peri-implant diseases, which are related to bacterial biofilm and host immune response. The results support the potential use of probiotics in managing gingivitis, cancer therapy-induced oral mucositis, and periodontitis [17][18][19][20] .…”

supporting

confidence: 68%

The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis

Cheng

Zeng

Liu

et al. 2020

Sci Rep

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There is currently a lack of effective drugs to cure recurrent aphthous stomatitis. This study aimed to evaluate the efficacy of probiotics alone or as an adjunct in recurrent aphthous stomatitis (RAS) patients. Seven randomized controlled trials (RCTs) were included, of which three were included in quantitative analysis. Of five studies evaluating the efficacy of probiotics alone compared with placebo or Oracure gel, two reported no significant difference in relieving oral pain, while probiotics exhibited a higher capacity for decreasing oral pain in the other three. A significant decrease in ulcer severity was found in one, while no significant difference was found in the other four. The remaining two studies demonstrated that probiotics, as an adjunct to steroids or anaesthetic antiseptic gel, significantly reduced the ulcer severity and oral pain. The meta-analysis showed a significant decrease in oral pain (− 1.72, P = 0.0001) with probiotics compared with placebo. In conclusion, probiotics alone were capable of relieving oral pain but not effective in reducing ulcer severity. A combination of probiotics and steroids or anaesthetic antiseptic gel was more effective than steroids or anaesthetic antiseptic gel alone in RAS patients. Probiotics are promising for the treatment of recurrent aphthous stomatitis.

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supporting

confidence: 68%

The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis

Cheng

Zeng

Liu

et al. 2020

Sci Rep

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“…Regeneration stimulating factors include platelet-derived factors, such as platelet-rich fibrin (PRF), plasma rich in growth factors (PRGF), and enamel matrix derivative (EMD). In the following section, the most promising therapeutic options are shortly described (19). Unfortunately, the evidence of systematic reviews is still scarce.…”

Section: Question 5: Should We Apply Additional Biologicals or Stem Cmentioning

confidence: 99%

“…While we can rely on a lot of positive evidence in the use of PRF in periodontology, available data on peri-implant regeneration are very limited (41). PRF-membranes in one randomized controlled clinical trial have been shown to be inferior to collagen membranes (19). The adjunctive use of PRF to OFD showed beneficial outcomes in terms of clinical attachment level (CAL) after 3 and 6 months (19).…”

Section: Autologous Platelet Concentratesmentioning

confidence: 99%

“…PRF-membranes in one randomized controlled clinical trial have been shown to be inferior to collagen membranes (19). The adjunctive use of PRF to OFD showed beneficial outcomes in terms of clinical attachment level (CAL) after 3 and 6 months (19).…”

Section: Autologous Platelet Concentratesmentioning

confidence: 99%

“…The biologic effect of EMD with its acceleration of wound healing (42), osteopromotive (43), and antibacterial (44) properties has already been shown in several studies, especially in the field of periodontitis and dental traumatology (43). One systematic review revealed no actual clinical benefit in regenerative periimplantitis therapy (19).…”

Section: Enamel Matrix Derivatives (Emd)mentioning

confidence: 99%

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Regenerative Surgical Therapy of Peri-implantitis: An Umbrella Review of Answered/Unanswered Questions and Future Perspectives

Solderer

Schmidlin

2020

Front. Dent. Med

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Purpose: To systemically summarize current knowledge about regeneration of peri-implant defects based on available systematic reviews.Materials and Methods: A systematic search for review articles published between 2010 and 2020 in four databases was conducted. Only systematic reviews and meta-analyses were included. Based on the available literature, five questions of clinical importance on indication for regenerative approaches, surgical technique, methods of decontamination, outcome of therapy and adjunctive use of biological factors were formulated and answered.Results: The electronic search resulted in 312 studies, from which 264 studies were published between 2010 and 2020. Finally, 18 systematic reviews and one consensus report were chosen. Data of the included studies were based on 58 to 840 implants. Data on over 4.904 implants were assessed. From the 19 studies that were included, 15 assessed the outcome of regenerative therapy; three, the surgical protocol of regenerative therapy; two, the use of laser in regenerative therapy; and one, the additional use of growth factors in regenerative peri-implant therapy. Three studies assessed more than one topic.Conclusions: In general, a partial bone fill can be expected in 85% of regenerative procedures. Regeneration leads to a mean of 57% of greater bone fill, compared to open flap surgery only. Defect configuration plays a crucial role in the outcome, whereas the role and extent of benefit of different surgical protocols are still not clear.

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Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of a randomized clinical trial

et al. 2022

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Objectives To compare the 3-year clinical and radiographic outcomes of two different reconstructive surgical management of peri-implantitis using a bone substitute in combination with either concentrated growth factor (CGF) or collagen membrane (CM). Material and methods Fifty-one patients who had at least one implant presenting peri-implantitis with an intrabony defect were filled with a xenogenic bone grafting material and covered either CGF or CM. Clinical and radiographic assessments were carried out at baseline and postoperative years 1 and 3. Three different composite outcomes were defined to evaluate treatment success at a 3-year follow-up. The effects of possible prognostic indicators on treatment success were identified by using multilevel regression analysis. Results The changes in probing depth (PD) and radiographic vertical defect depth (VDD) between baseline and year 1 and baseline and year 3 presented significantly greater decreases for the CM group in comparison with the CGF group (p < 0.05). No significant differences between the two treatment modalities were demonstrated regarding treatment success outcomes. History of periodontitis, VDD at baseline, and the number of intrabony defect walls revealed significant impacts on treatment success (p = 0.033; OR = 3.50, p = 0.039; OR = 0.975, and p = 0.024; OR = 7.0 and p = 0.019;OR = 6.0, respectively). Conclusions CM in combination with a bone substitute seems to have slightly better outcomes compared to the CGF membranes in reconstructive surgical therapy of peri-implantitis. The history of periodontitis, baseline VDD, and peri-implant bone defect configuration could be possible predictors influencing treatment success. Trial registration ClinicalTrials.gov NCT04769609. Clinical relevance For the reconstruction of peri-implant bone defects, using a bone substitute in combination with a collagen membrane may show more favorable outcomes.

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Efficacy of growth factors for the treatment of peri-implant diseases: a systematic review and meta-analysis

Cited by 6 publications

References 71 publications

The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis

The efficacy of probiotics in management of recurrent aphthous stomatitis: a systematic review and meta-analysis

Regenerative Surgical Therapy of Peri-implantitis: An Umbrella Review of Answered/Unanswered Questions and Future Perspectives

Efficacy of concentrated growth factor versus collagen membrane in reconstructive surgical therapy of peri-implantitis: 3-year results of a randomized clinical trial

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