Efficacy of double-coated probiotics for irritable bowel syndrome: a randomized double-blind controlled trial

Han, Kyungsun; Wang, Jinghwa; Seo, Jae-Gu; Kim, Hojun

doi:10.1007/s00535-016-1224-y

Cited by 29 publications

(28 citation statements)

References 42 publications

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“…The effects of antidepressants, anxiolytics, and even antipsychotics in the treatment of IBS also hint at the correlations between IBS and psychiatric disorders. The recent development of probiotics also found that gut flora could play a role in the development and management of IBS …”

Section: Discussionmentioning

confidence: 99%

Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study

et al. 2018

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“…Numerous studies have demonstrated decreased populations of Lactobacillus and Bifidobacterium and an increased presence of Veillonella, Clostridium coccoides, Streptococci , and Coliforms in IBS patients ( Malinen et al, 2005 ; Kassinen et al, 2007 ; Kang and Lee, 2014 ). Thus, therapies aiming to normalize or regulate the unbalanced gut microbiota, such as dietary interventions ( Chey, 2016 ), probiotics ( Han et al, 2016 ) and antibiotics ( Acosta et al, 2016 ), may have therapeutic potential for treatment of IBS.…”

Section: Introductionmentioning

confidence: 99%

Wuji Wan Formula Ameliorates Diarrhea and Disordered Colonic Motility in Post-inflammation Irritable Bowel Syndrome Rats by Modulating the Gut Microbiota

et al. 2017

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Emerging evidence suggests that gut microbiota contribute to the treatment of post-inflammatory irritable bowel syndrome (PI-IBS). Our previous studies have demonstrated that a Chinese formula, Wuji Wan, has the ability to mitigate abdominal pain and diarrhea in PI-IBS rats. However, little is known about the underlying mechanism and whether the gut microbiota mediate the effect of Wuji Wan on PI-IBS. Thus, the aim of this study was to determine whether Wuji Wan mitigated PI-IBS by modifying the gut microbiota. PI-IBS was induced in Sprague-Dawley rats by enema using 4% acetic acid and restraint stress. Rats were fed water, Wuji Wan extract (630 mg/kg) or pinaverium bromide (13.5 mg/kg). Our data showed that Wuji Wan effectively ameliorated abdominal pain, colonic motility abnormality and visceral hypersensitivity. Analysis of the fecal microbiota showed that Wuji Wan could reverse the reduction in richness of the gut microbiota and significantly increase the relative abundances of Akkermansia, Bacteroides, and Parasutterella; however, Lactobacillus and Prevotella were markedly decreased in the PI-IBS rats. Moreover, Wuji Wan promoted goblet cell proliferation in the colonic mucosa by increasing the release of mucin, up-regulating the distribution of tight junction proteins Occludin and ZO-1 and down-regulating the expression of MLCK in colonic epithelial cells. These findings suggest that Wuji Wan may remit IBS by modulating the gut microbiota and stabilizing the gut mucosal barrier, indicating that the use of a classical formula of Traditional Chinese Medicine (TCM) that exhibits a prebiotic effect may be a promising strategy for PI-IBS treatment.

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“…Kruis et al Os principais sintomas avaliados foram intensidade da dor, desconforto e distensão abdominal, frequência e consistência das fezes. Para essa avaliação, a escala de Bristol foi a mais utilizada (Han et al, 2017;Oh et al, 2019;Lyra et al, 2016;Hod et al, 2018;Yoon et al, 2014).…”

Section: Pré E Probióticos Efeitosunclassified

Prebióticos e probióticos na saúde e no tratamento de doenças intestinais: uma revisão integrativa

Marques

Cruz

Bezerra

et al. 2020

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Objetivo: realizar uma revisão integrativa sobre a função dos prebióticos e probióticos na manutenção da saúde, bem como suas aplicações no tratamento da constipação idiopática crônica (CIC), da síndrome do intestino irritável (SII) e da doença inflamatória intestinal (DII). Metodologia: trata-se de uma revisão integrativa da literatura, cuja busca dos estudos foi realizada nas bases de dados Cochrane e PubMed, com análise de trabalhos publicados nos últimos dez anos (2010-2020) escritos em inglês. Resultados: O uso de probióticos na CIC e SII mostrou efeitos benéficos na redução dos sintomas dessas doenças, modificação na microbiota e melhora na qualidade de vida dos pacientes. Na CIC, a inulina foi o prebiótico com mais efeitos positivos na sintomatologia da doença. Na DII, o uso de prebióticos e probióticos mostrou efeitos benéficos discretamente maiores para a RCU do que para a DC. Conclusão: Prebióticos e probióticos podem trazer tanto benefícios preventivos quanto terapêuticos à saúde intestinal, com ações diretas e indiretas na microbiota, imunidade e processos metabólicos do hospedeiro. A utilização desses compostos e microrganismos nas doenças estudadas demonstram resultados promitentes, principalmente, no campo dos probióticos. A partir da análise dos ensaios clínicos, as cepas promissoras no tratamento da DII foram Bifidobacterium, Lactobacillus, Enterococcus faecium (DC e RCU) e Clostridium butyricum (RCU). No entanto, salientamos a necessidade de estudos mais homogêneos no tratamento da DC com probióticos e prebióticos e o uso de prebióticos na SII.

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Efficacy of double-coated probiotics for irritable bowel syndrome: a randomized double-blind controlled trial

Abstract: Our result implies that dual-coating layers of probiotic supplement can be a candidate for treatment of diarrhea-predominant irritable bowel syndrome.

Cited by 29 publications

References 42 publications

Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study

Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study

Wuji Wan Formula Ameliorates Diarrhea and Disordered Colonic Motility in Post-inflammation Irritable Bowel Syndrome Rats by Modulating the Gut Microbiota

Prebióticos e probióticos na saúde e no tratamento de doenças intestinais: uma revisão integrativa

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