Efficacy of Different Drug Classes Used to Initiate Antihypertensive Treatment in Black Subjects

Abstract

In contrast to current recommendations, calcium channel blockers are more effective than thiazides as initial treatment in black subjects with hypertension. If treatment is started with thiazides or converting-enzyme inhibitors, combination therapy is more likely to be required to control blood pressure and reduce left ventricular mass.

Efficacy of newer versus older antihypertensive drugs in black patients living in sub-Saharan Africa

“…Our current findings are in agreement with a previous trial, 22 which showed that calcium-channel blockers are the most effective drug class to initiate antihypertensive treatment in South African blacks and that starting with thiazides or converting-enzyme inhibitors more often required combination therapy to control blood pressure. β-blockers without intrinsic sympathomimetic activity, such as bisoprolol, decrease heart rate and cardiac output.…”

Efficacy of newer versus older antihypertensive drugs in black patients living in sub-Saharan Africa

“…Our current findings are in agreement with a previous trial, 22 which showed that calcium-channel blockers are the most effective drug class to initiate antihypertensive treatment in South African blacks and that starting with thiazides or converting-enzyme inhibitors more often required combination therapy to control blood pressure. β-blockers without intrinsic sympathomimetic activity, such as bisoprolol, decrease heart rate and cardiac output.…”

Achieving blood preSsure goals sTudy in uncontrolled hypeRtensive pAtients treated with a fixed-dose combination of ramipriL / hydrochlorothiazide : the ASTRAL study

“…Similar results were reported from South Africa where enalapril was ineffective as monotherapy but the addition of either a diuretic or reserpine dramatically increased BP control rates 17. Underscoring the efficacy of fixed-dose ramipril/HCTZ in this study was the sustained and significant change in SBP and DBP from week zero to week eight and the fact that most of the patients remained on standard or half-standard dose of ramipril/HCTZ throughout the study duration.…”

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

“…The eNOS genotypes and haplotype distribution we found are consistent with the idea that Amerindians have less genetic diversity than other population groups, as detailed elsewhere (Wang et al, 2007). These findings may help to understand how the combination of polymorphisms and distinct haplotypes influence the interethnic disparities in NO bioavailability, cardiovascular risk (Stein et al, 1997;Sareli et al, 2001;Kalinowski et al, 2004;Li et al, 2004), and response to drugs (Nagassaki et al, 2006(Nagassaki et al, , 2008;;Souza-Costa et al, 2007).…”

Efficacy of newer versus older antihypertensive drugs in black patients living in sub-Saharan Africa

“…Our current findings are in agreement with a previous trial, 22 which showed that calcium-channel blockers are the most effective drug class to initiate antihypertensive treatment in South African blacks and that starting with thiazides or converting-enzyme inhibitors more often required combination therapy to control blood pressure. β-blockers without intrinsic sympathomimetic activity, such as bisoprolol, decrease heart rate and cardiac output.…”

Achieving blood preSsure goals sTudy in uncontrolled hypeRtensive pAtients treated with a fixed-dose combination of ramipriL / hydrochlorothiazide : the ASTRAL study

“…Similar results were reported from South Africa where enalapril was ineffective as monotherapy but the addition of either a diuretic or reserpine dramatically increased BP control rates 17. Underscoring the efficacy of fixed-dose ramipril/HCTZ in this study was the sustained and significant change in SBP and DBP from week zero to week eight and the fact that most of the patients remained on standard or half-standard dose of ramipril/HCTZ throughout the study duration.…”

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

“…The eNOS genotypes and haplotype distribution we found are consistent with the idea that Amerindians have less genetic diversity than other population groups, as detailed elsewhere (Wang et al, 2007). These findings may help to understand how the combination of polymorphisms and distinct haplotypes influence the interethnic disparities in NO bioavailability, cardiovascular risk (Stein et al, 1997;Sareli et al, 2001;Kalinowski et al, 2004;Li et al, 2004), and response to drugs (Nagassaki et al, 2006(Nagassaki et al, , 2008;;Souza-Costa et al, 2007).…”

Efficacy of newer versus older antihypertensive drugs in black patients living in sub-Saharan Africa

“…Our current findings are in agreement with a previous trial, 22 which showed that calcium-channel blockers are the most effective drug class to initiate antihypertensive treatment in South African blacks and that starting with thiazides or converting-enzyme inhibitors more often required combination therapy to control blood pressure. β-blockers without intrinsic sympathomimetic activity, such as bisoprolol, decrease heart rate and cardiac output.…”

Achieving blood preSsure goals sTudy in uncontrolled hypeRtensive pAtients treated with a fixed-dose combination of ramipriL / hydrochlorothiazide : the ASTRAL study

“…Similar results were reported from South Africa where enalapril was ineffective as monotherapy but the addition of either a diuretic or reserpine dramatically increased BP control rates 17. Underscoring the efficacy of fixed-dose ramipril/HCTZ in this study was the sustained and significant change in SBP and DBP from week zero to week eight and the fact that most of the patients remained on standard or half-standard dose of ramipril/HCTZ throughout the study duration.…”

Endothelial Nitric Oxide Synthase Polymorphisms and Haplotypes in Amerindians

“…The eNOS genotypes and haplotype distribution we found are consistent with the idea that Amerindians have less genetic diversity than other population groups, as detailed elsewhere (Wang et al, 2007). These findings may help to understand how the combination of polymorphisms and distinct haplotypes influence the interethnic disparities in NO bioavailability, cardiovascular risk (Stein et al, 1997;Sareli et al, 2001;Kalinowski et al, 2004;Li et al, 2004), and response to drugs (Nagassaki et al, 2006(Nagassaki et al, , 2008;;Souza-Costa et al, 2007).…”