Efficacy of Atorvastatin Reload in Patients on Chronic Statin Therapy Undergoing Percutaneous Coronary Intervention

Clearfield, Michael

doi:10.1007/s11883-009-0083-x

Cited by 4 publications

(3 citation statements)

References 12 publications

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“…A recent metaanalysis has confirmed that most of the beneficial effects of statins are independent of their lipid-lowering action. Several studies show that statins decrease C-reactive protein (CRP) levels [88][89][90]. The clinical trials Cardiovascular Inflammation Reduction Trial (CIRT) and Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) have researched this hypothesis with promising results.…”

Section: Conventional Therapiesmentioning

confidence: 99%

Involvement of Inflammation and Its Resolution in Disease and Therapeutics

Alfaro

Acuña

Ceriani

et al. 2022

IJMS

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Inflammation plays a critical role in the response to and survival from injuries and/or infections. It occurs in two phases: initiation and resolution; however, when these events do not resolve and persist over time, the inflammatory response becomes chronic, prompting diseases that affect several systems and organs, such as the vasculature and the skin. Here, we reviewed inflammation that occurs in selected infectious and sterile pathologies. Thus, the immune processes induced by bacterial sepsis as well as T. cruzi and SARS-CoV-2 infections are shown. In addition, vaccine adjuvants as well as atherosclerosis are revised as examples of sterile-mediated inflammation. An example of the consequences of a lack of inflammation resolution is given through the revision of wound healing and chronic wounds. Then, we revised the resolution of the latter through advanced therapies represented by cell therapy and tissue engineering approaches, showing how they contribute to control chronic inflammation and therefore wound healing. Finally, new pharmacological insights into the management of chronic inflammation addressing the resolution of inflammation based on pro-resolving mediators, such as lipoxin, maresin, and resolvins, examining their biosynthesis, biological properties, and pharmacokinetic and pharmaceuticals limitations, are given. We conclude that resolution pharmacology and advanced therapies are promising tools to restore the inflammation homeostasis.

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Section: Conventional Therapiesmentioning

confidence: 99%

Involvement of Inflammation and Its Resolution in Disease and Therapeutics

Alfaro

Acuña

Ceriani

et al. 2022

IJMS

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“…Many studies demonstrated that high-dose atorvastatin pretreatment reduces periprocedural MI and myocardial injury in both stable angina during elective PCI and ACS patients undergoing an early invasive strategy [ 33 , 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction

Adel

Elberry

Aziz

et al. 2022

JCM

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The aim of this study was to compare the effect of a single high-dose rosuvastatin versus atorvastatin preloading in ST-elevation myocardial infarction (STEMI) patients receiving primary percutaneous coronary intervention (PCI.) Methods: A total of 99 patients presented with STEMI and were randomly divided into three groups—a control group (n = 33) with no statin treatment, an atorvastatin group (n = 33) with a single 80 mg atorvastatin dose and the rosuvastatin group (n = 33) with a single 40 mg rosuvastatin dose in the emergency room (ER) prior to PCI. Post-interventional thrombolysis in myocardial infarction (TIMI) flow grade and corrected TIMI frame count (CTFC) were recorded, and ST-segment resolution was measured. Results: CTFC was significantly lower for the atorvastatin group (p-value < 0.01) than in the control group. A final TIMI flow grade 3 was achieved in 32 (97.0%) patients in the rosuvastatin group and 28 (84.8%) patients in the atorvastatin group compared with only 25 (75.8%) patients in the control group (p = 0.014). Peak CK-MB in the rosuvastatin group (263.2 [207.2–315.6]) and the atorvastatin group (208 [151.0–314.1]) was lower compared to that in the control group (398.4 [303.9–459.3]); p < 0.001. Conclusions: A single extensive dose of lipophilic atorvastatin prior to primary PCI in STEMI patients showed better improvement in microvascular myocardial perfusion compared to hydrophilic rosuvastatin.

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“…In a previous clinical practice, it was found that the use of high-dose statins before an emergency PCI promote healing, improved prognosis and reduces the incidence of no-reflow phenomenon after PCI (24). It is generally assumed that the no-reflow phenomenon is due to thrombosis formation, embolism and elevated blood lipids in the local tissue microcirculation under infarction.…”

Section: Discussionmentioning

confidence: 99%

Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI

Liu

Zou

Jiang

et al. 2016

Experimental and Therapeutic Medicine

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The aim of the present study was to evaluate the use of preoperative high-dose atorvastatin to prevent the no-reflow phenomenon after percutaneous coronary intervention (PCI). A total of 138 patients with ST-segment elevation myocardial infarction, admitted from March 2014 to January 2015, were enrolled and randomly divided into 3 groups of 46 individuals each. The groups included a control group in which patients were not treated with atorvastatin before PCI; a conventional-dose atorvastatin treatment group in which patients received a single dose of 20 mg at bedtime one day prior to PCI; and a high-dose atorvastatin treatment group in which patients were treated with 40 mg divided in two doses the day before PCI. The treatment effects were assessed by re-examining the echocardiography, high-sensitivity C-reactive protein and brain natriuretic peptide (BNP) levels after the PCI. The follow-up examinations included determinations of ultrasound imaging indicators and the contact with patients was maintained for a whole year. The CTFC (frame), pro-BNP, CK-MB peak and WMSI levels of the patients in the high-dose treatment group were significantly lower than those in the conventional dose or the control group. Trombolysis in myocardial infarction ≤2 and myocardial blush grade ≤1 levels were significantly lower than those in the conventional dose group (P=0.01) or those in the control group (P=0.01), although the echocardiographic indicators of the three groups were not significantly different (P<0.05). Nevertheless, it was found that there were significantly fewer adverse cardiovascular events in the high-dose group (P<0.05 in both cases). During the follow-up period, thromboembolism and restenosis were most infrequent in the high-dose atorvastatin group. Based on our findings the oral administration of high-dose atorvastatin before bedtime, one day before the procedure, can effectively prevent no-reflow cases, reduce adverse events and improve the long-term prognosis for acute coronary syndrome patients after PCI.

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Efficacy of Atorvastatin Reload in Patients on Chronic Statin Therapy Undergoing Percutaneous Coronary Intervention

Cited by 4 publications

References 12 publications

Involvement of Inflammation and Its Resolution in Disease and Therapeutics

Involvement of Inflammation and Its Resolution in Disease and Therapeutics

Comparison of the Treatment Efficacy of Rosuvastatin versus Atorvastatin Loading Prior to Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction

Clinical effect of preoperative high-dose atorvastatin against no-reflow after PCI

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