Efficacy of atmospheric pressure dielectric barrier discharge for inactivating airborne pathogens

Romero-Mangado, Jaione; Dey, Avishek; Díaz-Cartagena, Diana C; Solis-Marcano, Nadja E.; López-Nieves, Marjorie; Santiago-García, Vilynette; Nordlund, Dennis; Krishnamurthy, S.; Meyyappan, M.; Koehne, Jessica E.; Gandhiraman, Ram P.

doi:10.1116/1.4990654

Cited by 7 publications

(7 citation statements)

References 36 publications

(43 reference statements)

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“…Romero‐Mangado et al [ 19 ] studied the effect of DBD on aerosolized E. coli concluding that the cell structure is damaged to a varying extent and severe oxidation of the cell membrane is found, establishing effective inactivation of the bacteria. Romero‐Mangado et al [ 29 ] also demonstrated the possibility to inactivate bioaerosol containing S. epidermidis or Aspergillus niger , respectively, a Gram‐positive bacteria and fungal spores by means of CAP treatment. The morphology observed on the scanning electron microscope (SEM) micrographs shows deformations in the cellular structure of both microorganisms.…”

Section: Introductionmentioning

confidence: 99%

“…Cell structure damage upon interaction with the DBD suggests leakage of vital cellular materials, which is a key mechanism for microbial inactivation. [ 29 ] Nayak et al [ 23 ] shows that a volumetric DBD is effective in inactivating aerosolized porcine reproductive and respiratory syndrome (PRRS) virus in a wind tunnel within a few milliseconds, timescales relevant for typical heating, ventilation, and air conditioning (HVAC) conditions (few milliseconds). A 3.5‐log reduction in the viable PRRS virus titer is achieved and the inactivation effect is independent of the discharge power and the sampling time.…”

Section: Introductionmentioning

confidence: 99%

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Cold atmospheric plasma inactivation of aerosolized microdroplets containing bacteria and purified SARS‐CoV‐2 RNA to contrast airborne indoor transmission

Bisag

Isabelli

Laurita

et al. 2020

Plasma Processes & Polymers

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One of the major concerns in the COVID-19 pandemic is related to the possible transmission in poorly ventilated spaces of SARS-CoV-2 through aerosol microdroplets, which can remain in the air for long periods of time and be transmitted to others over distances >1 m. Cold atmospheric pressure plasmas can represent a promising solution, thanks to their ability in producing a blend of many reactive species, which can inactivate the airborne aerosolized microorganisms. In this study, a dielectric barrier discharge plasma source is used to directly inactivate suitably produced bioaerosols containing Staphylococcus epidermidis or purified SARS-CoV-2 RNA flowing through it. Results show that for low residence times (<0.2 s) in the plasma region a 3.7 log R on bacterial bioaerosol and degradation of viral RNA can be achieved. K E Y W O R D S bioaerosol, cold plasma, inactivation, indoor airborne transmission, SARS-CoV-2 Alina Bisag and Pasquale Isabelli contributed equally to this study.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cold atmospheric plasma inactivation of aerosolized microdroplets containing bacteria and purified SARS‐CoV‐2 RNA to contrast airborne indoor transmission

Bisag

Isabelli

Laurita

et al. 2020

Plasma Processes & Polymers

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“…Operating rooms with turbulent mechanical ventilation or without ventilation are not acceptable for orthopedic and traumatic surgery on COVID-19 patients. A safe technical solution is an innovative mobile filter system, which first sucks in room air through an M5 prefilter [26] , [27] . Then, the air passes through a G4 carbon pleated filter.…”

Section: Gas Plasma Technology and Decontaminationmentioning

confidence: 99%

Gas Plasma Technology—An Asset to Healthcare During Viral Pandemics Such as the COVID-19 Crisis?

Bekeschus

Krämer

Suffredini

et al. 2020

IEEE Trans. Radiat. Plasma Med. Sci.

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The COVID-19 crisis profoundly disguised the vulnerability of human societies and healthcare systems in the situation of a pandemic. In many instances, it became evident that the quick and safe reduction of viral load and spread is the foremost principle in the successful management of such a pandemic. However, it became also clear that many of the established routines in healthcare are not always sufficient to cope with the increased demand for decontamination procedures of items, healthcare products, and even infected tissues. For the last 25 years, the use of gas plasma technology has sparked a tremendous amount of literature on its decontaminating properties, especially for heat-labile targets, such as polymers and tissues, where chemical decontamination often is not appropriate. However, while the majority of earlier work focused on bacteria, only relatively few reports are available on the inactivation of viruses. We here aim to provide a perspective for the general audience of the chances and opportunities of gas plasma technology for supporting healthcare during viral pandemics such as the COVID-19 crisis. This includes possible real-world plasma applications, appropriate laboratory viral test systems, and critical points on the technical and safety requirements of gas plasmas for virus inactivation.

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“…Various types of plasma devices for these purposes were developed in recent years. The most widely studied and used plasma sources for bio-medical applications in various configurations and designs are based on the dielectric barrier discharge (DBD) and the atmospheric pressure plasma jets (APPJ) [13][14][15]. In [16], the plasma sources (assuming that the plasma is produced between electrodes) are categorized in three types: (i) direct plasma sources, when one of the electrodes is the sample (human body); (ii) indirect plasma sources, when the plasma is produced between two electrodes and the active plasma components are transported to the treated sample; and (iii) hybrid plasma sources-surface micro discharge (SMD) technology.…”

Section: Introductionmentioning

confidence: 99%

Characteristics of 2.45 GHz Surface-Wave-Sustained Argon Discharge for Bio-Medical Applications

Benova

Marinova

Tafradjiiska-Hadjiolova

et al. 2022

Applied Sciences

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Cold atmospheric plasma (CAP) applications in various fields, such as biology, medicine and agriculture, have significantly grown during recent years. Many new types of plasma sources operating at atmospheric pressure in open air were developed. In order to use such plasmas for the treatment of biological systems, plasma properties should fulfil strong requirements. One of the most important is the prevention from heating damage. That is why in many cases, the post-discharge region is used for treatment, but the short living particles in the active discharge zone and reactions with them are missed in that case. We use the active region of surface-wave-sustained argon plasma for biological systems treatment. The previous investigations showed good bactericidal, virucidal, seeds germination and decontamination effects at a short treatment time, but the discharge conditions for bio-medical applications need specific adjustment. A detailed theoretical and experimental investigation of the plasma characteristics and their possible optimization in order to meet the requirements for bio-medical applications are presented in this paper. The length of the plasma torch, the temperature at the treatment sample position and the microwave radiation there are estimated and optimized by the appropriate choice of discharge tube size, argon flow rate and microwave power.

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Efficacy of atmospheric pressure dielectric barrier discharge for inactivating airborne pathogens

Abstract: Ram P. (2017). Efficacy of atmospheric pressure dielectric barrier discharge for inactivating airborne pathogens. Journal of Vacuum Science and Technology A: Vacuum, Surfaces, and Films, 35(4) 041101. For guidance on citations see FAQs.

Cited by 7 publications

References 36 publications

Cold atmospheric plasma inactivation of aerosolized microdroplets containing bacteria and purified SARS‐CoV‐2 RNA to contrast airborne indoor transmission

Cold atmospheric plasma inactivation of aerosolized microdroplets containing bacteria and purified SARS‐CoV‐2 RNA to contrast airborne indoor transmission

Gas Plasma Technology—An Asset to Healthcare During Viral Pandemics Such as the COVID-19 Crisis?

Characteristics of 2.45 GHz Surface-Wave-Sustained Argon Discharge for Bio-Medical Applications

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