Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: Results of two placebo-controlled trials

Borenstein, David G.; Korn, Scott

doi:10.1016/s0149-2918(03)80067-x

Cited by 84 publications

(18 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although these drugs can relieve musculoskeletal pain, these effects may not be specific, and there is no evidence that they relax skeletal muscle in the clinical setting. Although they have been shown to reduce musculoskeletal pains [129][130][131][132][133], their risk:benefit ratio relative to the NSAIDs or opioids is unknown [133]. The most common adverse effect is sedation, which can be additive to other centrally acting drugs, including opioids.…”

Section: Adjuvant Analgesics Used For Musculoskeletal Painmentioning

confidence: 99%

Adjuvant Analgesics in Cancer Pain Management

2004

View full text Add to dashboard Cite

Adjuvant analgesics are defined as drugs with a primary indication other than pain that have analgesic properties in some painful conditions. The group includes numerous drugs in diverse classes. Although the widespread use of these drugs as first-line agents in chronic nonmalignant pain syndromes suggests that the term "adjuvant" is a misnomer, they usually are combined with a less-than-satisfactory opioid regimen when administered for cancer pain. Some adjuvant analgesics are useful in several painful conditions and are described as multipurpose adjuvant analgesics (antidepressants, corticosteroids, α α 2 -adrenergic agonists, neuroleptics), whereas others are specific for neuropathic pain (anticonvulsants, local anesthetics, N-methyl-D-aspartate receptor antagonists), bone pain (calcitonin, bisphosphonates, radiopharmaceuticals), musculoskeletal pain (muscle relaxants), or pain from bowel obstruction (octreotide, anticholinergics). This article reviews the evidence supporting the use of each class of adjuvant analgesic for the treatment of pain in cancer patients and provides a comprehensive outline of dosing recommendations, side effects, and drug interactions. The Oncologist 2004;9:571-591

show abstract

Section: Adjuvant Analgesics Used For Musculoskeletal Painmentioning

confidence: 99%

Adjuvant Analgesics in Cancer Pain Management

2004

View full text Add to dashboard Cite

show abstract

“…Cyclobenzaprine alone, however, has demonstrated efficacy in acute muscle spasm of the neck and back. 43 One study showed no difference in pain relief between patients receiving 5 mg 3 times per day and 10 mg 3 times per day. Sedation was lower in the former group.…”

Section: Emergency Department Managementmentioning

confidence: 99%

Evaluation and Management of Acute Cervical Spine Trauma

Pimentel

Diegelmann

2010

Emergency Medicine Clinics of North America

View full text Add to dashboard Cite

“…1a), was first introduced in 1977 and is a widely prescribed skeletal muscle relaxant with proven efficacy and safety profile in the treatment of acute muscle spasm, acute cervical strain and myofascial pain in occidental populations [1,2].…”

Section: Cyclobenzaprine Hcl (Cyc)mentioning

confidence: 99%