Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy [RETIRED]

French, Jacqueline; Kanner, Andrés M.; Bautista, Jocelyn F.; Abou‐Khalil, Bassel; Browne, Thomas R.; Harden, Cynthia L.; Theodore, William H.; Bazil, Carl W.; Stern, John M.; Schachter, Steven C.; Bergen, Donna; Hirtz, Deborah; Montouris, Georgia; Nespeca, Mark; Gidal, Barry E.; Marks, William J.; Turk, William R.; Fischer, James H.; Bourgeois, Blaise F. D.; Wilner, Andrew N.; Faught, R. Edward; Sachdeo, Rǎjesh C.; Beydoun, Ahmad; Glauser, Tracy A.

doi:10.1212/01.wnl.0000123693.82339.fc

Cited by 476 publications

(207 citation statements)

References 107 publications

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“…The unnecessary use of antiepileptic agents can alter the metabolism of many other drugs as steroids, chemotherapeutic agents and other antiepileptic, after inducing hepatic P450 enzymes (phenytoin, carbamazepine, phenobarbital). Actually there are a large number of agents free of inducing hepatic enzymes, with relatively few drug interactions (French et al, 2004). Although infrequent, patients with brain tumors comprise 4-12 % of patients developing status epilepticus (Wen et al, 2006).…”

Section: Seizuresmentioning

confidence: 99%

Management of Brain Tumors in Eloquent Areas

Darder¹,

López²

2011

Diagnostic Techniques and Surgical Management of Brain Tumors

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Section: Seizuresmentioning

confidence: 99%

Management of Brain Tumors in Eloquent Areas

Darder¹,

López²

2011

Diagnostic Techniques and Surgical Management of Brain Tumors

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“…Para epilepsias parciais recém-diagnosticadas, as principais medicações a serem consideradas são a carbamazepina, oxcar-bazepina, fenitoína, lamotrigina e topiramato. 9,10 Em unidades de emergência, quando é necessário uma introdução medicamentosa mais rápida, a fenitoína é a medicação de escolha em nosso meio devido a sua disponibilidade na forma injetável.…”

Section: B) Epilepsia Recém-diagnosticadaunclassified

Tratamento das epilepsias parciais

Betting

Guerreiro

2008

J. epilepsy clin. neurophysiol.

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RESUMOAs epilepsias parciais constituem a forma mais comum de epilepsia nos indivíduos adultos. As drogas antiepilépticas (DAEs) permanecem como a principal forma de tratamento para os pacientes com epilepsia. Apesar da importância da medicação um número elevado de pacientes permanece sob um regime terapêutico inapropriado ou até mesmo sem qualquer medicação. Existem várias medicações disponíveis para o tratamento das epilepsias. A escolha de uma medicação específica ou a associação entre DAEs deve ser particularizada o máximo possível. Neste artigo revisamos alguns aspectos como classificação, início das crises, idade, sexo, comorbidades, custo e posologia das DAEs e história medicamentosa com a perspectiva de auxiliar nesta individualização do tratamento. Algumas características das principais DAEs disponíveis também são discutidas. Estes aspectos podem auxiliar na criação de um perfil ajudando assim na escolha do regime terapêutico mais apropriado para cada indivíduo. Aspectos práticos como o manuseio dos efeitos adversos, monoterapia e politerapia também são abordados. Unitermos: Epilepsia parcial, epilepsia focal, tratamento medicametoso, monoterapia, politerapia, drogas antiepilépticas. AbSTRAcT Partial epilepsies treatmentPartial epilepsies are the most common form of epilepsy in adult individuals. Antiepileptic drugs (AEDs) continue as the main form of treatment for patients with epilepsy. Regardless of the importance of the medication a high number of patients are under inappropriate or not receiving AEDs. There are several medications available for the treatment of epilepsy. The choice of a particular medication or association among AEDs may be individualized as much as possible. In this article some aspects such as classification, onset of the seizures, age, sex, associated medical conditions, cost and posology of AEDs and medical drug history are reviewed. Details of the available AEDs are also discussed. These points may help to create a profile helping the decision for the appropriate AED. Some practical issues like adverse reaction management, monotherapy and politherapy are also discussed. Key words: Partial epilepsy, focal epilepsy, medical treatment, monotherapy, polytherapy, antiepileptic drugs. InTROdUçãOAs epilepsias parciais constituem a forma mais comum de epilepsia no adulto. 1 O tratamento apropriado é de fundamental importância e tem como objetivo prevenir a ocorrência de crises epilépticas proporcionando melhor qualidade de vida para o paciente. O tratamento medicamentoso permanece sendo a principal forma de terapia para os pacientes com epilepsia. Apesar da disponibili-* Doutor em Neurologia -FCM-UNICAMP. ** Professor Titular de Neurologia -FCM-UNICAMP. Received July 28, 2008; accepted Aug. 22, 2008. dade das medicações e dos avanços nesta área, 38% dos pacientes permanecem recebendo tratamento inadequado e até 20% dos pacientes com epilepsia permanecem sem medicações. 2 As epilepsias parciais são caracterizadas por crises parciais simples e complexas. 3 Nas crises parciais simples...

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“…Recently published AED treatment guidelines from the American Academy of Neurology and the American Epilepsy Society for the use of GBP, LTG, TPM, TGB, OXC, LEV, and ZNS in the treatment of new-onset and medically refractory seizures are based on evidence of efficacy, tolerability, and safety in adults and children. 66,67 However, while clinical practice is ideally evidence-based, there are clinical situations requiring AED selections for which there are few if any relevant clinical studies. 68 For example, there are few head-to-head studies of currently available AEDs as initial therapy for specific seizure types or age groups.…”

Section: Aed Selection: Guidelines and Expert Opinionmentioning

confidence: 99%

Currently Available Antiepileptic Drugs

Schachter

2007

Neurotherapeutics

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Summary:Many new antiepileptic drugs (AEDs) have become available over the past 15 years. At the same time, the emphasis on treating patients with epilepsy has grown from stopping seizures to avoiding side effects and maximizing quality of life. This review summarizes currently available AEDs, and presents general treatment principles and guidelines for AED selection. Unfortunately, despite the increased treatment options of today, seizure freedom without side effects remains unattainable for too many patients with epilepsy. Consequently, there remains a significant need for further development of new therapies.

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Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new onset epilepsy [RETIRED]

Abstract: The results of this evidence-based assessment provide guidelines for the prescription of AEDs for patients with newly diagnosed epilepsy and identify those seizure types and syndromes where more evidence is necessary.

Cited by 476 publications

References 107 publications

Management of Brain Tumors in Eloquent Areas

Management of Brain Tumors in Eloquent Areas

Tratamento das epilepsias parciais

Currently Available Antiepileptic Drugs

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