Efficacy and Safety of Taeeumjowi-tang in Obese Korean Adults: A Double-Blind, Randomized, and Placebo-Controlled Pilot Trial

Abstract

Objective. The purpose of this study was to assess the efficacy and safety of Taeeumjowi-tang (TJ001) as well as to estimate obesity-related factors. Methods. This was a 12-week trial with 5 visits. A total of 102 participants of both genders were randomized to either TJ001 (n = 57) group or the placebo group (n = 55). Subjects were administered 7 g of either TJ001 or placebo 3 times a day. The primary outcome was a rate of subjects who lost 5% or more of initial weight. Secondary outcomes included anthropometric parameters, lipid profiles, and body fat composition. Results. The subject response rate of ≥5% weight loss compared to baseline was similar in both groups, and no statistically significant difference was observed (P = 0.87). Changes in anthropometric parameters were greater during the first 4 weeks in the treatment group (P < 0.0001). There were no significant changes in both within groups and between groups for lipid profile and body fat composition. No adverse event was reported in either group. Conclusion. Although the difference between the groups regarding a rate of subjects who lost 5% or more of initial weight did not show statistical significance, TJ001 appears to be beneficial in safely controlling weight.

Differential Protein Expression in White Adipose Tissue from Obesity-Prone and Obesity-Resistant Mice in Response to High Fat Diet and Anti-Obesity Herbal Medicines

“…The anti-obesity effects of these compounds are mediated by regulation of various metabolic processes, including feeding-inhibitory actions, elevation of lipolysis, reduction of lipogenesis, and differentiation of preadipocytes [15,16,17]. Taeumjowi-tang (designated as ‘'TH'') is a traditional Korean medicine that is widely used to treat several diseases [18,19]. This product consists of multiple compounds and has become the standard treatment regimen for obesity by Korean medical professionals, and its use has been expanded to all types of obesity [20,21].…”

“…Taeumjowi-tang (designated as ‘'TH'') is a traditional Korean medicine that is widely used to treat several diseases [18,19]. This product consists of multiple compounds and has become the standard treatment regimen for obesity by Korean medical professionals, and its use has been expanded to all types of obesity [20,21]. In previous studies, TH and TH modified prescription have been evaluated for its inhibitory effects on obesity, suggesting that its modified prescription can clinically be useful as anti-obesity drugs and can be useful for the improvement of hyperlipidemia [22,23].…”

Systematic Review on Herbal Treatment for Obesity in Adults

“…최종적으로 선정된 13편의 무작위 대조군 임상연구에 서 사용한 한약은 방풍통성산과 위약을 비교한 임상연구 4편 [9][10][11][12] , 태음조위탕 2편 13,14) , 방기황기탕 1편 15) , 방풍통성 산과 방기황기탕을 각각의 군에 배정한 논문 1편이었다 16) .…”

Recent progress and prospects in Sasang constitutional medicine: A traditional type of physiome-based treatment

“…Park evaluated the efficacy and safety of a Taeeumjowi-tang, TE herbal formula, in obese Korean adults in an RCT (Park et al, 2012(Park et al, , 2013. Lee performed a drug-gene study on Taeeumjowi-tang, which affects body weight and obesity-related genes in mice (Lee et al, 2009b).…”