Efficacy and safety of quercetin and polyvinylpyrrolidone in treatment of patients with newly diagnosed destructive pulmonary tuberculosis in comparison with standard antimycobacterial therapy

Butov, Dmytro; Zaitseva, Svetlana; Butova, Tetyana; Stepanenko, Ganna; Pogorelova, Olga; Zhelezniakova, Natalia

doi:10.1016/j.ijmyco.2016.06.012

Cited by 16 publications

(11 citation statements)

References 21 publications

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“…This worsens the course of TB, resulting in the subsequent loss of a part or even the whole organ. All this complicates the penetration of oral ATD in the focus of tuberculous inflammation [4,30]. Intravenous chemotherapy increases the concentration of ATD in the blood in a short period of time, ensures a rapid access of these drugs to the focus of tuberculous inflammation and the use of solutions of intravenous ATD provides faster detoxication in patients with TB [15,22].…”

Section: Discussionmentioning

confidence: 99%

“…The most prominent achievements of phthisiology are associated with the development of antimycobacterial therapy. Performance targets for further improvement of the newly diagnosed pulmonary TB treatment determine not only the increasing of destructions closure frequency and negation of sputum, but also the use of therapies www.journals.viamedica.pl that can achieve sustainable results within shorter time without forming large residual changes in the lungs [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…The lack of therapeutic effect may be caused by the development of drug resistance [14], the inability to create optimal concentrations of the drugs in the blood and tissues [15] as a result of their incomplete absorption in the gastrointestinal tract [16] and accumulation in the inflammation area [4,17], or rapid inactivation of the drugs [18].…”

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of intravenous chemotherapy during intensive treatment phase in patients with newly diagnosed pulmonary tuberculosis

Butova¹,

Бутов²

2021

Int J Mycobacteriol

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Introduction:The purpose of our study was to examine the efficacy and safety of intravenous chemotherapy during intensive treatment phase in patients with newly diagnosed pulmonary tuberculosis (pulmonary TB). Material and methods:The study involved 92 patients with newly diagnosed pulmonary TB aged between 20 and 68. All patients with newly diagnosed pulmonary TB and chemosensitive tuberculosis were enrolled in the study. The patients were allocated to two groups. The first (control) group of 46 patients received standard chemotherapy orally. The second (main) group consisted of 46 patients who were prescribed isoniazid, rifampin, ethambutol by i.v. infusion, and pyrazinamide orally as a part of the standard treatment. Results: Symptoms of intoxication and chest manifestations in pulmonary TB patients from the second group were eliminated faster than the same symptoms in the group 1. In the group 2, the mycobacterial clearance in sputum smears was achieved more rapidly, and up to 2 months it was reached in 37 patients (80.43%), while in the control group in 25 patients (54.35%),p = 0.0066. Destruction healing and inflitrative change alleviation after 4 months was reached in 38 patients (82.61%) (in control group -28 (60.87%), (p = 0.0192). No additional negative effects were detected when compared with the control group at any time. Conclusions: Thanks to i.v. chemotherapy, clinical manifestations of the in-patients with pulmonary TB were eliminated faster, severe side effects of anti-TB drugs were not noticed, time of bacterial clearance and healing of destruction was shorter, healing frequency of destructions increased and the of residual changes decreased.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Efficacy and safety of intravenous chemotherapy during intensive treatment phase in patients with newly diagnosed pulmonary tuberculosis

Butova¹,

Бутов²

2021

Int J Mycobacteriol

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“…Quercetin and polyvinylpyrrolidone (QP) are capillary stabilizing agents and antioxidants with immunomodulatory activities. It can promote the growth of endothelial cells, induce the activation of microcirculation in inflammation sites, and reduce inflammation and blood coagulation ( Butov et al., 2016 ). QP combined with chemotherapy to treat patients with APTB rapidly improved the clinical symptoms and signs, significantly reduced the sputum bacteria and pulmonary cavity, increased lesion absorption, decreased expression of IL-1β and TNF-α with a substantial increase in IL-4, as well as an increase in nitric oxide (NO) at the inflammatory site with no side effects, suggesting that QP might be a new potential immunotherapy ( Butov et al., 2016 ).…”

Section: Chemical Agentsmentioning

confidence: 99%

The Research Progress in Immunotherapy of Tuberculosis

Liang

et al. 2021

Front. Cell. Infect. Microbiol.

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Tuberculosis (TB) is a serious public health problem worldwide. The combination of various anti-TB drugs is mainly used to treat TB in clinical practice. Despite the availability of effective antibiotics, effective treatment regimens still require long-term use of multiple drugs, leading to toxicity, low patient compliance, and the development of drug resistance. It has been confirmed that immune recognition, immune response, and immune regulation of Mycobacterium tuberculosis (Mtb) determine the occurrence, development, and outcome of diseases after Mtb infection. The research and development of TB-specific immunotherapy agents can effectively regulate the anti-TB immune response and provide a new approach toward the combined treatment of TB, thereby preventing and intervening in populations at high risk of TB infection. These immunotherapy agents will promote satisfactory progress in anti-TB treatment, achieving the goal of “ultra-short course chemotherapy.” This review highlights the research progress in immunotherapy of TB, including immunoreactive substances, tuberculosis therapeutic vaccines, chemical agents, and cellular therapy.

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“…erefore, Qt formula could be recommended for further clinical study for COVID-19 and other viral pulmonary infections [114]. In patients with newly diagnosed destructive pulmonary tuberculosis, treatment with Qt and polyvinylpyrrolidone QP (5 g in 100 mL of 0.9% sodium chloride solution intravenously once a day for 10 days) resulted in quick reduction of the disease manifestation [115]. e reviewed papers indicated the effect of the extracts, essential oil, and the constituents of onion, mainly Qt, on viral, microbial, parasitic, and fungal infections in the lung.…”

Section: Clinical Evidencementioning

confidence: 99%

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

Beigoli

Behrouz

Memarzia

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The health benefits of Allium cepa (A. cepa) have been proclaimed for centuries. Various pharmacological and therapeutic effects on respiratory, allergic, and immunologic disorders are shown by A. cepa and its constituents. Flavonoids such as quercetin and kaempferol, alk(en)yl cysteine sulfoxides including S-methyl cysteine sulfoxide and S-propyl cysteine sulfoxide, cycloalliin, thiosulfinates, and sulfides are the main compounds of the plant. A. cepa displays broad-spectrum pharmacological activities including antioxidant, anti-inflammatory, antihypertensive, and antidiabetic effects. Our objective in this review is to present the effects of A. cepa and its constituents on respiratory, allergic, and immunologic disorders. Different online databases were searched to find articles related to the effect of A. cepa extracts and its constituents on respiratory, allergic, and immunologic disorders until the end of December 2020 using keywords such as onion, A. cepa, constituents of A. cepa, therapeutic effects and pharmacological effects, and respiratory, allergic, and immunologic disorders. Extracts and constituents of A. cepa showed tracheal smooth muscle relaxant effects, indicating possible bronchodilator activities or relieving effects on obstructive respiratory diseases. In experimental animal models of different respiratory diseases, the preventive effect of various extracts and constituents of A. cepa was induced by their antioxidant, immunomodulatory, and anti-inflammatory effects. The preventive effects of the plant and its components on lung disorders induced by exposure to noxious agents as well as lung cancer, lung infection, and allergic and immunologic disorders were also indicated in the experimental and clinical studies. Therefore, this review may be considered a scientific basis for development of therapies using this plant, to improve respiratory, allergic, and immunologic disorders.

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Efficacy and safety of quercetin and polyvinylpyrrolidone in treatment of patients with newly diagnosed destructive pulmonary tuberculosis in comparison with standard antimycobacterial therapy

Abstract: Administration of QP combined with chemotherapy in patients with newly diagnosed destructive pulmonary tuberculosis resulted in a comparatively quick reduction of disease manifestation.

Cited by 16 publications

References 21 publications

Efficacy and safety of intravenous chemotherapy during intensive treatment phase in patients with newly diagnosed pulmonary tuberculosis

Efficacy and safety of intravenous chemotherapy during intensive treatment phase in patients with newly diagnosed pulmonary tuberculosis

The Research Progress in Immunotherapy of Tuberculosis

Effects of Allium cepa and Its Constituents on Respiratory and Allergic Disorders: A Comprehensive Review of Experimental and Clinical Evidence

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