Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial

Kopke, Richard D.; Slade, Martin D.; Jackson, Ronald L.; Hammill, Tanisha L.; Fausti, Stephen A.; Lonsbury‐Martin, Brenda L.; Sanderson, Alicia R.; Dreisbach, Laura E.; Rabinowitz, Peter; Torre, Peter; Balough, B.J.

doi:10.1016/j.heares.2015.01.002

Cited by 84 publications

(66 citation statements)

References 41 publications

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“…As an alternative analysis plan, one could prospectively plan to assess potential reductions in participants with larger TTS changes, as in the preliminary report by Kil et al (2014). In a different study that assessed prevention of permanent threshold shift (PTS), Kopke et al [2015] used this analysis approach to assess a potential reduction in the rate of PTS using NAC as a potential therapeutic agent. In the study presented here, there were 20 ears out of 140 tested (14% of the total participant pool) where TTS at 4 kHz was 10 dB or greater at the 15-min test time.…”

Section: Discussionmentioning

confidence: 99%

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

Prell

Fulbright

Spankovich

et al. 2016

Audiol Neurotol Extra

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This study examined potential prevention of music-induced temporary threshold shift (TTS) in normal-hearing participants. A dietary supplement composed of β-carotene, vitamins C and E, and magnesium was assessed using a randomized, placebo-controlled, double-blind study design. Dosing began 3 days prior to the music exposure with the final dose consumed approximately 30-min pre-exposure. Post-exposure TTS was measured, with no significant difference as a function of treatment. Distortion product otoacoustic emission amplitudes were suppressed after music exposure in both groups, with no significant difference as a function of treatment. Tinnitus was more likely to be reported by the treatment group, but there were no group differences in perceived loudness or bothersomeness. Taken together, this supplement had no effect on noise-induced changes in hearing. Recommendations for future clinical trials are discussed.

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Section: Discussionmentioning

confidence: 99%

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

Prell

Fulbright

Spankovich

et al. 2016

Audiol Neurotol Extra

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“…evaluating the effect on the right ear only in right handed participants). In summary, there is potentially a small benefit of NAC in reducing the rate of threshold shift in a noise-exposed population [176]. …”

Section: Pharmacological Treatmentsmentioning

confidence: 99%

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Le¹,

Straatman²,

Lea³

et al. 2017

J of Otolaryngol - Head & Neck Surg

308

235

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BackgroundNoise-induced hearing loss is one of the most common forms of sensorineural hearing loss, is a major health problem, is largely preventable and is probably more widespread than revealed by conventional pure tone threshold testing. Noise-induced damage to the cochlea is traditionally considered to be associated with symmetrical mild to moderate hearing loss with associated tinnitus; however, there is a significant number of patients with asymmetrical thresholds and, depending on the exposure, severe to profound hearing loss as well.Main bodyRecent epidemiology and animal studies have provided further insight into the pathophysiology, clinical findings, social and economic impacts of noise-induced hearing loss. Furthermore, it is recently shown that acoustic trauma is associated with vestibular dysfunction, with associated dizziness that is not always measurable with current techniques. Deliberation of the prevalence, treatment and prevention of noise-induced hearing loss is important and timely. Currently, prevention and protection are the first lines of defence, although promising protective effects are emerging from multiple different pharmaceutical agents, such as steroids, antioxidants and neurotrophins.ConclusionThis review provides a comprehensive update on the pathophysiology, investigations, prevalence of asymmetry, associated symptoms, and current strategies on the prevention and treatment of noise-induced hearing loss.

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“…Likewise, a randomized trial of 566 military subjects on weapons training had differentiated outcomes depending on the analyses used 98 . There were no differences in the primary outcomes, threshold shifts and percent of adverse events, between the placebo group and NAC (a total daily dose of 2700 mg NAC for each of the first 13 days of training followed by three days of 1800 mg).…”

Section: Human Studiesmentioning

confidence: 99%

Emerging therapeutic interventions against noise-induced hearing loss

Sha

Schacht

2016

Expert Opinion on Investigational Drugs

105

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Introduction Noise-induced hearing loss (NIHL) due to industrial, military, and recreational noise exposure is a major, but also potentially preventable cause of acquired hearing loss. For the United States it is estimated that 26 million people (15% of the population) between the ages of 20 and 69 have a high-frequency NIHL at a detriment to the quality of life of the affected individuals and great economic cost to society. Areas covered This review outlines the pathology and pathophysiology of hearing loss as seen in humans and animal models. Results from molecular studies are presented that have provided the basis for therapeutic strategies successfully applied to animals. Several compounds emerging from these studies (mostly antioxidants) are now being tested in field trials. Expert opinion Although no clinically applicable intervention has been approved yet, recent trials are encouraging. In order to maximize protective therapies, future work needs to apply stringent criteria for noise exposure and outcome parameters. Attention needs to be paid not only to permanent NIHL due to death of sensory cells but also to temporary effects that may show delayed consequences. Existing results combined with the search for efficacious new therapies should establish a viable treatment within a decade.

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Efficacy and safety of N-acetylcysteine in prevention of noise induced hearing loss: A randomized clinical trial

Cited by 84 publications

References 41 publications

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

Dietary Supplement Comprised of β-Carotene, Vitamin C, Vitamin E, and Magnesium: Failure to Prevent Music-Induced Temporary Threshold Shift

Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options

Emerging therapeutic interventions against noise-induced hearing loss

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