Efficacy and safety of ethylmethylhydroxypyridine succinate in patients with ischemic stroke

Журавлева, М. В.; Ia, Shchukin; Fidler, Mikhail; Prokofiev, A. B.; Serebrova, S. Yu.; Vasyukova, N.S.; Demchenkova, E. Yu.; Архипов, В. В.

doi:10.17116/jnevro202012012260

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…The Russian drug Mexidol, which has multimodal actions, has demonstrated its high effi cacy in IS. A large number of studies have been reported, including double-blind, placebo-controlled studies compliant with international GCP standards in which the effi cacy of Mexidol in stroke was confi rmed using an evidence-based medicine approach [70].…”

Section: Mechanisms Of Development Of Acute Cerebral Stroke In Covid-19mentioning

confidence: 99%

“…Two mechanisms for the involvement of the endothelium can be distinguished: on the one hand, a direct spread predominantly by the air droplet route. A study in China in 1875 patients hospitalized with COVID-19 showed that 2.7% were diagnosed with IS, these being older patients (70 [64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] and 62 years, p < 0.001), who had higher incidences of arterial hypertension and other cardiovascular diseases [6]. A study reported by Qureshi and William [7] in 8163 patients hospitalized with COVID-19 showed that 103 (1.3%) were diagnosed with acute IS.…”

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confidence: 99%

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COVID-19-Associated Stroke

Shchukin

Fidler

Koltsov

et al. 2022

Neurosci Behav Physi

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The COVID-19 pandemic has had significant influences on the incidence of acute cerebrovascular accidents and the structure of mortality. SARS-CoV-2 increases the risks of developing both ischemic and hemorrhagic stroke. The key pathogenetic element underlying the development of cerebral stroke in COVID-19 consists of impairments to the operation of angiotensin 2 receptors, which are accompanied by accumulation of excess quantities of angiotensin 2, endothelial dysfunction, hypercoagulation, overproduction of proinflammatory cytokines, and an oxidative storm. In patients with stroke and COVID-19, lesion severity is associated with dual mechanisms of ischemia – systemic and cerebral. The possibilities of medication-based correction of both systemic impairments associated with coronavirus infection and local impairments due to ischemic or hemorrhagic brain damage, are limited. Substances with antioxidant activity may potentially be effective in patients with stroke and COVID-19. Data from a number of clinical rials indicate that Mexidol significantly improves functional outcomes in ischemic stroke. Use of Mexidol in patients with stroke and COVID-19 is advised.

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Section: Mechanisms Of Development Of Acute Cerebral Stroke In Covid-19mentioning

confidence: 99%

mentioning

confidence: 99%

COVID-19-Associated Stroke

Shchukin

Fidler

Koltsov

et al. 2022

Neurosci Behav Physi

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“…The mechanism of action of this drug consists of antioxidant and membrane-protective action. It suppresses lipid peroxidation processes and increases the activity of superoxide dismutase, which neutralizes the starting radical of free radical processes [16]. Under conditions of tissue ischemia, this drug enhances the compensatory activation of aerobic glycolysis, reduces the degree of inhibition of oxidative processes in the Krebs cycle, and promotes the activation of ATP synthesis.…”

mentioning

confidence: 99%

The Antioxidant Protection System State of Rats Under Experimental Doxorubicin Intoxication and the Effects of Correcting Factors

Gutyj

Varkholiak

Verveha

et al. 2023

MCCh

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Introduction. The doxorubicin model was used for research, which, according to many authors, most adequately reproduces heart failure of varying degrees of severity. Doxorubicin is an antibiotic that has a cytostatic effect. The mechanism of its action consists of interaction with DNA, formation of free radicals, and inhibition of nucleic acid synthesis. The doxorubicin action and the development of hypoxia are accompanied by the activation of oxidative stress, the strengthening of free radical processes, and changes in the metabolism of carbohydrates, proteins, and lipids. The aim of the study – the effect of the drug “Bendamine” on the indicators of antioxidant protection of the body of rats under experimental simulation of heart failure. Research Methods. Modeling of heart failure was performed on sexually mature male Wistar rats with a body weight of 180–200 g. In blood and myocardial homogenate, the level of lipid peroxidation products, the activity of antioxidant enzymes, and the level of reduced glutathione were determined against the background of doxorubicin intoxication and when using the drug “Bendamine”. Results and Discussion. During doxorubicin intoxication, LPO processes are enhanced in rats, which is indicated by the increased lipid hydroperoxides, diene conjugates, and TBA-active products in the blood and the homogenate of the rat myocardium of the first experimental group. It is worth noting that the inhibition of the antioxidant defense system was also established in intoxicated rats, as indicated by the low level of both enzymatic and non-enzymatic links of the antioxidant system. It was established that bendamine has a corrective effect on rats' oxidative stress conditions inherent in doxorubicin-induced heart failure. The drug “Bendamine” inhibits the excessive formation of POL products in pathologically changed tissues of the heart of rats and has an inducing effect on the system of antioxidant protection. Conclusions. The influence of the drug "Bendamine" on the indicators of antioxidant protection of the body of rats under experimental simulation of heart failure was studied. Its antioxidant properties have been proven.

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