Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus

Caumes, E.

doi:10.1001/archderm.133.4.465

Cited by 18 publications

(9 citation statements)

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“…We developed a novel desensitization schedule for procarbazine for patient A, based on available schedules for other nonimmediate hypersensitivity reactions and our institutional experience (Table 2). 7,8 Three oral solutions of 0.1 mg/mL, 1 mg/mL, and 10 mg/mL were prepared, based on Lehmann et al 9 Procarbazine was gradually updosed in 12 steps over four consecutive days. No additional anti‐allergic drugs were used during desensitization; nonetheless, the reintroduction remained uneventful and the third and fourth cycle of PCV chemotherapy could be successfully administered using this desensitization schedule.…”

Section: Patient Age (Y) Gender Oncologic Diagnosis Start Of Allergicmentioning

confidence: 99%

Successful oral desensitization and reintroduction in selected glioma patients with procarbazine‐mediated hypersensitivity

Valk

Dijkstra

Walenkamp

et al. 2020

Allergy

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Section: Patient Age (Y) Gender Oncologic Diagnosis Start Of Allergicmentioning

confidence: 99%

Successful oral desensitization and reintroduction in selected glioma patients with procarbazine‐mediated hypersensitivity

Valk

Dijkstra

Walenkamp

et al. 2020

Allergy

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“…It has been well established that outpatient protocols of varying lengths successfully allow HIV patients with a history of adverse drug reactions to TMP-SMX to tolerate administration [13,14]. Outpatient desensitization also works well in patients without HIV infection, and 1-day protocols, when compared to longer protocols, may have greater long-term success rates without differing short-term outcomes [15].…”

Section: Antibioticsmentioning

confidence: 99%

Immediate Drug Hypersensitivity

Wickner

Hong

2016

Curr Allergy Asthma Rep

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“…A number of desensitization protocols with co-trimoxazole have been described, with a success rate of 60% to 100% [61]. Unfortunately, very little is known about the most important factor in obtaining successful desensitization.…”

Section: Desensitization or Rechallenge Protocolsmentioning

confidence: 99%

Allergic adverse reactions to sulfonamides

Choquet-Kastylevsky¹,

Vial²,

Descotes³

2002

Curr Allergy Asthma Rep

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Antimicrobial sulfonamides were the first antimicrobial agents used effectively to treat infectious diseases. However, because they may cause severe adverse drug reactions (ADRs) and because more effective agents have since been developed, sulfonamides now are used for only a few indications in specific groups, such as AIDS patients. Skin reactions, from benign rash to potentially lethal toxidermias, are the most frequent ADRs to sulfonamides. Other major ADRs include acute liver injury, pulmonary reactions, and blood dyscrasias. Although the mechanisms involved have not been fully elucidated, reactive metabolites appear to play a pivotal role. The hydroxylamine and nitroso metabolites of sulfamethoxazole, the most frequently used sulfonamide today, can bind covalently to proteins because of their chemical reactivity, resulting in the induction of specific adverse immune responses. Therefore, changes in the activity of metabolic and detoxification pathways are associated with a greater risk for developing allergic reactions to sulfonamides. Allergies to sulfonamides, particularly sulfamethoxazole (often used in combination with trimethoprim as co-trimoxazole), are more frequent in AIDS patients, but the reason for this increased risk is not fully understood. No valid tools are available to predict which patients have a greater risk for developing allergies to sulfonamides. Diagnosis is essential to avoid a possible evolution toward severe reactions and readministration of the offending drug. In patients who absolutely require further treatment, successful desensitization may be achieved.

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Efficacy and safety of desensitization with sulfamethoxazole and trimethoprim in 48 previously hypersensitive patients infected with human immunodeficiency virus

Cited by 18 publications

References 0 publications

Successful oral desensitization and reintroduction in selected glioma patients with procarbazine‐mediated hypersensitivity

Successful oral desensitization and reintroduction in selected glioma patients with procarbazine‐mediated hypersensitivity

Immediate Drug Hypersensitivity

Allergic adverse reactions to sulfonamides

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