Efficacy and safety of dapoxetine in treatment of premature ejaculation: an evidence-based review

Russo, Andrea; Capogrosso, Paolo; Ventimiglia, Eugenio; Croce, Giovanni La; Boeri, Luca; Montorsi, Francesco; Salonia, Andrea

doi:10.1111/ijcp.12843

Cited by 42 publications

(32 citation statements)

References 56 publications

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“…Pharmacological investigations have shown that dapoxetine is a potent inhibitor of the 5‐HT transporter, that its pharmacokinetics are not affected by age, ethnicity or dosing frequency (with doses of 30 and 60 mg) and that “on‐demand” usage is effective (Andersson, Mulhall, & Wyllie, ), making dapoxetine a novel effective treatment modality for PE (Simsek et al., ). The results of several studies show that dapoxetine can improve the symptoms of PE, prolong IELT and increase sexual satisfaction (Simsek et al., ; Russo et al., ). In our study, therefore, patients with PPE received dapoxetine (30 mg) treatment of at least 12 tablets (on demand) before a re‐check.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response

Kati

2018

Andrologia

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Hyperactivity of the sympathetic nervous system may play an important role in primary premature ejaculation (PPE), and dapoxetine, a selective serotonin reuptake inhibitor, plays a role in its treatment. We evaluated the success of dapoxetine treatment in PPE patients with a penile sympathetic skin response (PSSR). Of 63 patients who were admitted to our outpatient clinic between March 2017 and December 2017 with a complaint of premature ejaculation and diagnosed with PPE, 56 completed treatment (minimum 12 tablets) with on-demand use 30 mg of dapoxetine and returned for a follow-up appointment. Before and after treatment, the International Index of Erectile Function (IIEF-5) and Arabic index PE (AIPE) scores, intravaginal ejaculation latency time (IELT), testosterone values and PSSR values were compared. The IELT and AIPE values increased significantly in the 56 patients who were re-evaluated after dapoxetine treatment. No significant changes were observed in testosterone levels and IIEF-5. In the PSSR measurement, while the amplitude decreased, the latency was prolonged significantly. PSSR may be an important determinant in the measurement of dapoxetine treatment success for PPE patients, but additional studies are needed.

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Section: Discussionmentioning

confidence: 99%

Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response

Kati

2018

Andrologia

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“…Moreover, no adverse effects of the PFM rehabilitation protocol were identified, compared to other medical therapies such as gastrointestinal symptoms (nausea and diarrhea) and dizziness and headaches, which have been associated with the use of dapoxetine. 22,23 In addition, the long-term effects of dapoxetine on reproductive functions should be cleared as some recent data demonstrated its negative impact on fertility. 24 To the best of our knowledge, the present study has the longest follow-up period (36 months) reported to date for any intervention for PE.…”

Section: Discussionmentioning

confidence: 99%

Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: Long-term outcomes

Pastore¹,

Fuschi²,

Salhi³

et al. 2018

European Urology Supplements

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stimulus but, rather, due to a failure to selectively produce an effective contraction of the pelvic floor. 7 Therefore, in our study, men with lifelong PE underwent pelvic floor muscle (PFM) rehabilitation, using a modification of techniques used for the treatment of urinary and fecal incontinence, 6 and including physio-kinesiotherapy treatments, electrostimulation, and biofeedback. The primary endpoint of our study was to evaluate the effectiveness of PFM rehabilitation by measuring the change, from baseline, in IELT and the self-administered Premature Ejaculation Diagnostic Tool (PEDT) over a follow-up period of 36 months. The secondary endpoint was to investigate the long-term effectiveness of PFM rehabilitation in training patients to recognize when and how to control the muscles involved in the ejaculatory reflex. PARTICIPANTS AND METHODS Participants A total of 154 male participants were retrospectively reviewed in this study, which was conducted between September 2012 and December 2013. To be included in the study, participants had to be in a stable relationship, with the same partner, for at least 6 months and to engage

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“…Сегодня дапоксетин считается единственным эффек тивным и безопасным пероральным препаратом лечения ПЭ, использование которого может улучшить качество жизни пациента и сексуального партнера [56][57][58][59].…”

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Solving the problem of premature ejaculation in practice of the urologue

Горпинченко¹,

Спиридоненко²

2017

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Efficacy and safety of dapoxetine in treatment of premature ejaculation: an evidence-based review

Abstract: Dapoxetine is the only effective and safe available on-label oral treatment for PE, and its use can result in better quality of life for the patient and their sexual partner.

Cited by 42 publications

References 56 publications

Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response

Evaluation of dapoxetine treatment success in lifelong premature ejaculation patients with penile sympathetic skin response

Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation: Long-term outcomes

Solving the problem of premature ejaculation in practice of the urologue

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