Efficacy and Limitation of F-18-fluorodeoxyglucose Positron Emission Tomography during Fasting to Assess Myocardial Viability in the Acute Phase of Myocardial Infarction.

Nonogi, Hiroshi; Miyazaki, Shunichi; Goto, Yoichi; Ishida, Yoshiteru; Uehara, Toshiisa

doi:10.2169/internalmedicine.37.653

Cited by 4 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[36][37][38] However, 18 F-FDG uptake does not always mean viable myocardium in patients with AMI because 18 F-FDG can gather in the inflammatory cells in the infarcted area during the acute phase of AMI. [39][40][41] Stunned myocardium is very important for myocardial viability in patients with AMI and the mismatch area between myocardial perfusion and 123 I-BMIPP uptake has been important for the evaluation of this stunned myocardium. 42 However, because the GIK-201 Tl uptake area was wider than that of 201 Tl uptake in the present study, the mismatch area between the uptake of GIK-201 Tl and 123 I-BMIPP might be wider than that between 201 Tl and 123 I-BMIPP.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Salvaged Myocardium After Acute Myocardial Infarction Using Single Photon Emission Computed Tomography After 201Tl-Glucose-Insulin Infusion

Toyama

Hara

Seki

et al. 2004

Circ J

View full text Add to dashboard Cite

he prognosis of patients with acute myocardial infarction (AMI) has improved with reperfusion therapy, 1-12 but even with successful reperfusion therapy, the myocardium may be stunned and regional wall motion (RWM) at the infarcted area decreased. [13][14][15] In patients with AMI, it is clinically important to distinguish viable from nonviable myocardium to predict whether the RWM will eventually improve. Positron emission tomography (PET) is considered the gold standard for assessing myocardial viability, but alternative procedures based on radionuclide imaging have been proposed. 201 Tl myocardial scintigraphy has been widely used to detect myocardial viability using either a late redistribution 16 or a reinjection imaging technique 17,18 in patients with coronary artery disease. A recent study by Tartagni et al describes a new method for cardiac imaging after infusion of 201 Tl, insulin, and potassium in a glucose solution, which improved the detection of viable myocardium. 19 Insulin augments the myocardial uptake of potassium through translocation of Na-K ATPase from the cytosol to the sarcolemma. 20,21 Likewise, 201 Tl is taken up by myocardium through Na-K ATPase, 22,23 and its uptake is also enhanced by insulin. We compared the efficacy of resting 201 Tl imaging with resting 201 Tl imaging after glucose -insulin -potassium infusion for detecting viable myocardium after AMI. Methods PatientsThirty-seven patients with AMI who had undergone successful percutaneous transluminal coronary angioplasty (PTCA) or stenting within 6 h of the onset of symptoms were recruited. The diagnosis of AMI was based on the following criteria: acute chest pain lasting more than 30 min, serum creatine kinase (CK) concentration greater than 500 IU, and development of abnormal Q waves on electrocardiogram.Patients who fulfilled the following criteria were included in the statistical analysis: successful PTCA or coronary stenting (or both) with angiographic confirmation of <25% residual stenosis, no significant stenosis in other vessels, good image quality on all radiotracer studies during subacute and chronic phases, and patency without restenosis on follow-up coronary angiography 6 months after AMI. Restenosis was defined as a decrease in lumen diameter by >50% compared with after reperfusion therapy. Patients with diabetes or glucose intolerance were excluded from the study. Glucose intolerance was defined when fasting glucose concentration was more than 110 mg/dl and less than 126 mg/dl, or the glucose concentration at 2 h after 75 g glucose loading was more than 140 mg/dl and less than 200 mg/dl. The final study population comprised 25 patients (13 men, 12 women; age 41-82 years, mean age 67±13 years). The infarct-related vessel

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Salvaged Myocardium After Acute Myocardial Infarction Using Single Photon Emission Computed Tomography After 201Tl-Glucose-Insulin Infusion

Toyama

Hara

Seki

et al. 2004

Circ J

View full text Add to dashboard Cite

show abstract

“…Additionally, some reports of fasting 18 F-FDG-PET affirm the influence of inflammation on infarcted myocardium. 16 …”

mentioning

confidence: 99%

Serial Changes in Glucose-Loaded 18F-Fluoro-2-Deoxyglucose Positron Emission Tomography, 99mTc-Tetrofosmin and 123I-Beta-Methyl-p-Iodophenyl-Penta-Decanoic Acid Myocardial Single-Photon Emission Computed Tomography Images in Patients With Anterior Acute Myocardial Infarction

Fukuoka

Horita

Namura

et al. 2013

Circ J

View full text Add to dashboard Cite

Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp he energy metabolism of the heart and the utilization of substrates including glucose, fatty acids, amino acids, lactic acid and ketone bodies depend on circumstances, 1 and are primarily based on fatty acid metabolism and glucose metabolism in a competitive manner. 2 However, a shift to anaerobic metabolism because of low oxygen supplies causes ischemic myocardium to primarily utilize glucose. 3,4 Many reports have discussed whether maintaining glucose metabolism is important in estimating the viability of ischemic myocardium, and some reports indicate that improvements in left ventricular function and the prevention of cardiac events are achieved with the use of aggressive revascularization procedures. 5-9 The use of glucose-loaded 18 F-fluoro-2-deoxyglucose ( 18 F-FDG) PET has played a central role in helping cardiovascular interventionalists decide whether revascularization procedures are indicated in patients with old myocardial infarction (MI) with residual stenosis and angina pectoris. 10-13 18 F-FDG-PET has been also utilized to evaluate systemic inflammatory diseases, including malignancies, because 18 F-FDG accumulates in sites of inflammation. 14,15 Therefore, appropriate timing for the evaluation of glucose-loaded 18 F-FDG-PET images of acute MI (AMI) has been conventionally considered T

show abstract

Evaluation of myocardial viability following acute myocardial infarctic using201Tl SPECT after thallium-glucose-insulin infusion —Comparison with18F-FDG positron emission tomography—

et al. 2004

View full text Add to dashboard Cite

show abstract

Efficacy and Limitation of F-18-fluorodeoxyglucose Positron Emission Tomography during Fasting to Assess Myocardial Viability in the Acute Phase of Myocardial Infarction.

Cited by 4 publications

References 16 publications

Evaluation of Salvaged Myocardium After Acute Myocardial Infarction Using Single Photon Emission Computed Tomography After 201Tl-Glucose-Insulin Infusion

Evaluation of Salvaged Myocardium After Acute Myocardial Infarction Using Single Photon Emission Computed Tomography After 201Tl-Glucose-Insulin Infusion

Evaluation of myocardial viability following acute myocardial infarctic using201Tl SPECT after thallium-glucose-insulin infusion —Comparison with18F-FDG positron emission tomography—

Contact Info

Product

Resources

About