Effects on bone mineral density of calcium and vitamin D supplementation in elderly women with vitamin D deficiency

Grados, Franck; Brazier, Michel; Kamel, Saı̈d; Duver, Sigolène; Heurtebize, N.; Maamer, M.; Mathieu, M.; Garabédian, M; Sébert, J. L.; Fardellone, Patrice

doi:10.1016/s1297-319x(03)00046-0

Cited by 69 publications

(39 citation statements)

References 20 publications

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“…Grados et al (38) studied nursing home patients and found that 53.6% had vitamin D25(OH) levels ,12 ng/ mL without any neurologic contributing factors. They ascribed their findings to age-associated reduced absorption of vitamins in the gastrointestinal tract, limited sunlight exposure, and low dietary intake of vitamin D.…”

Section: Discussionmentioning

confidence: 99%

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Oleson

Patel

Wuermser

2010

The Journal of Spinal Cord Medicine

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Background: Inadequate levels of vitamin D increase the risk of osteoporosis, a highly prevalent condition in patients with traumatic spinal cord injury (SCI). Reduced sunlight and dark skin further contribute to low vitamin D levels. Objectives: To compare serum 25-hydroxy vitamin D [vitamin D25(OH)] levels in acute and chronic SCI and to explore seasonal and ethnic differences among patients with acute and chronic SCI. Patients/Methods: Patients (N 5 96) aged 19 to 55 years with C3-T10 motor complete SCI participated. Acute SCI was 2 to 6 months after injury, whereas chronic SCI was at least 1 year from injury. Serum vitamin D25(OH), calcium, and parathyroid hormone were drawn during summer or winter months. Vitamin D deficiency (,13 ng/mL), insufficiency (,20 ng/mL), and subtherapeutic (,32 ng/mL) levels were compared for all groups. A 3-way analysis of covariance was adopted to determine significant main effects of season, chronicity, and ethnicity. Interactions between season and chronicity, season and ethnicity, and chronicity and ethnicity were evaluated. Evaluation of a 3-way interaction among season, chronicity, and ethnicity was completed. Results: In summer, 65% of patients with acute SCI and 81% of patients with chronic SCI had subtherapeutic vitamin D levels, whereas in winter, 84% with acute SCI and 96% with chronic SCI had vitamin D25(OH) (,32ng/mL). Lower vitamin D25(OH) levels were observed in African Americans relative to whites. Significant main effects were noted for season (P 5 0.017), chronicity (P 5 0.003), and ethnicity (P , 0.001). However, interactions between 2 or more factors were not found. Conclusions: Vitamin D insufficiency and deficiency are found in the majority of patients with chronic SCI and in many with acute SCI. Initial screening for serum vitamin D25(OH) levels should be performed early in rehabilitation. Periodic monitoring in the chronic setting is highly recommended.

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Section: Discussionmentioning

confidence: 99%

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Oleson

Patel

Wuermser

2010

The Journal of Spinal Cord Medicine

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“…In that study, however, serum 25(OH)D levels were initially higher (77 nmol l À1 ) compared with our group (36 nmol l À1 ). Other large dose calcium/ vitamin D supplementation studies in elderly residents have not documented rates of 25(OH)D deficiency (Krieg et al, 1999;Peacock et al, 2000;Grados et al, 2003) nor did they measure serum 25(OH)D at follow-up (Flicker et al, 2005;Law et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

et al. 2007

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Objectives: To assess the effectiveness of a multivitamin (MV) tablet on nutritional status, quantitative heel ultrasound (QUS), mobility, muscle strength and falls. The design comprised two groups matched on mobility levels, randomized to receive a daily MV or placebo (P) tablet for 6 months. The setting was an Australian residential care facility. Subjects: A total of 92 aged care residents. Serum micronutrients, body weight, QUS, rate of falls, hand grip strength, and the timed up and go test were assessed at baseline and 6 months. Results: A total of 49 participants consumed a MV and 43, a matched P for 6 months. There was a greater increase in the MV vs P group for serum 25(OH)D (mean difference ± standard error, 33.4 ± 2.6 nmol l À1 ), folate (13.4 ± 2.8 nmol l À1 ), and vitamin B12 (178.0±40.3 pmol l À1 ) (all Po0.001). Adequate 25(OH)D concentrations (X50 nmol l À1 ) were found among 77% of participants in the MV group vs 10% taking P (Po0.001). Adjusting for baseline levels, the increase in QUS was greater in the MV vs P group (3.0±2.0 dB MHz À1 vs À2.9±2.1 dB MHz À1 , respectively, P ¼ 0.041). There was a trend towards a 63% lower mean number of falls in the MV vs P group (0.3 ± 0.1 falls vs 0.8 ± 0.3 falls, P ¼ 0.078). Conclusions: MV supplementation raised serum vitamin B12 and folate concentrations and increased serum 25(OH)D, which was accompanied by an apparent positive effect on bone density. We also found a trend towards a reduction in falls and this could contribute to a reduction in fractures.

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“…[46][47][48] In older women (> 65 years), daily vitamin D 3 17.5 or 20 µg (700 or 800 IU) resulted in small but significant increases in bone mineral density in the lumbar spine and femoral neck relative to placebo. 49,50 Similarly, the Women's Health Initiative found, in a subgroup of 2431 women taking vitamin D and calcium supplements, a 1.06% increase in total hip density (p < 0.001) 41 (level 1 evidence).…”

Section: Traditional Roles Of Vitamin D Effect On Bone Mineral Densitymentioning

confidence: 99%

“…In these cases, serum 25-hydroxyvitamin D should be measured as part of the initial assessment, and supplementation with vitamin D should be based on the measured value. Supplementation dose requirements above the current definition of tolerable upper intake level (50 12,37 To achieve desirable vitamin D status (> 75 nmol/L) many individuals will require doses greater than this minimum dose.…”

Section: -32mentioning

confidence: 99%

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada

Hanley

Cranney²,

Jones³

et al. 2010

Canadian Medical Association Journal

235

119

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Effects on bone mineral density of calcium and vitamin D supplementation in elderly women with vitamin D deficiency

Cited by 69 publications

References 20 publications

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Influence of Season, Ethnicity, and Chronicity on Vitamin D Deficiency in Traumatic Spinal Cord Injury

Multivitamin supplementation improves nutritional status and bone quality in aged care residents

Vitamin D in adult health and disease: a review and guideline statement from Osteoporosis Canada

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