Effects of wall shear stress and fluid recirculation on the localization of circulating monocytes in a three-dimensional flow model

Pritchard, William H.; Davies, Peter; Derafshi, Ziba; Polacek, Denise C.; Tsao, Raychang; Dull, Randall; Jones, Steven A.; Giddens, Don P.

doi:10.1016/0021-9290(95)00094-1

Cited by 77 publications

(35 citation statements)

References 24 publications

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“…It has been shown Karino and Goldsmith, 1984) in vitro that regions in the neighborhood of the stagnation point are prone to thrombus formation, as platelets tend to strongly adhere to the wall at these sites. It has also been shown for steady flow in perfusion models (Pritchard et al, 1995) that blood monocyte adhesion to the vessel wall is inversely correlated to wall shear stress and is strongly influenced by the magnitude of in-plane flow and the presence of flow separation. In addition a recent investigation by Hinds et al (2001) with both steady and pulsatile flow in a three dimensional perfusion model showed that blood monocyte adhesion was significantly higher in the locality of the flow separation region as compared to the post reattachment and pre-separation regions.…”

Section: Discussionmentioning

confidence: 99%

The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis

Papaharilaou

Doorly

Sherwin

2002

Journal of Biomechanics

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Section: Discussionmentioning

confidence: 99%

The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis

Papaharilaou

Doorly

Sherwin

2002

Journal of Biomechanics

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“…23,43,49,63 This is a key point, because these processes are fundamental to the initiation of inflammatory responses due to alterations in the residence time of atherogenic particles. 8,17 Moreover, bulky flow structures are primarily responsible for mass transfer, 7,33 in particular, for those species within blood that take advantage of mixing induced by convection.…”

Section: On the Role Of Bulk Flowmentioning

confidence: 99%

Quantitative Analysis of Bulk Flow in Image-Based Hemodynamic Models of the Carotid Bifurcation: The Influence of Outflow Conditions as Test Case

Morbiducci

Gallo

Ponzini³

et al. 2010

Ann Biomed Eng

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Although flow-driven mechanisms associated with vascular physiopathology also deal with four-dimensional phenomena such as species transport, the majority of the research on the subject focuses primarily on wall shear stress as indicator of disturbed flow. Indeed, the role that bulk flow plays in vascular physiopathology has not been thoroughly investigated, partly because of a lack of descriptors that would be able to reduce the intricacy of arterial hemodynamics. Here, an approach is proposed to investigate, in silico, the bulk flow within the carotid bifurcation. For this purpose, we coupled a three-dimensional model of carotid bifurcation with a lumped model of the downstream vasculature. For the sake of comparison, we also imposed three different fixed flow rate repartitions between the internal and external carotid arteries on the three-dimensional model. The bulk flow was characterized by applying a descriptor of helical motion, the helical flow index (HFI) to the model; the HFI has recently been shown to provide an accurate representation of complex flows. Moreover, a new metric is presented to investigate the vorticity dynamics within the bifurcation. Our results highlight the effectiveness of these metrics in the following contexts: (i) identifying and ranking emerging hemodynamic features and (ii) quantifying the influence of the outflow boundary conditions on the composition of the translational and rotational components of the fluid motion. The metrics applied herein allow for a more comprehensive analysis, which may lead to the development of an instrument to relate the bulk flow to vascular pathophysiological events that involve not only fluid-related forces, but also transport phenomena within blood.

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“…Hemodynamics has long been identified as a major influence in the formation and localization of atherosclerotic plaques (1,(18)(19)(20)(21)(22)(23). More recent works have focused primarily on regions of flow separation (2,4).…”

Section: Introductionmentioning

confidence: 99%

Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions

Richter¹,

Groothuis²,

Seifert³

et al. 2004

J. Clin. Invest.

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Although arterial bifurcations are frequent sites for obstructive atherosclerotic lesions, the optimal approach to these lesions remains unresolved. Benchtop models of arterial bifurcations were analyzed for flow disturbances known to correlate with vascular disease. These models possess an adaptable geometry capable of simulating the course of arterial disease and the effects of arterial interventions. Chronic in vivo studies evaluated the effect of flow disturbances on the pattern of neointimal hyperplasia. Acute in vivo studies helped propose a mechanism that bridges the early mechanical stimulus and the late tissue effect. Sidebranch (SB) dilation adversely affected flow patterns in the main branch (MB) and, as a result, the long-term MB patency of stents implanted in pig arteries. Critical to this effect is chronic MB remodeling that seems to compensate for an occluded SB. Acute leukocyte recruitment was directly influenced by the changes in flow patterns, suggesting a link between flow disturbance on the one hand and leukocyte recruitment and intimal hyperplasia on the other. It is often impossible to simultaneously maximize the total cross-sectional area of both branches and to minimize flow disturbance in the MB. The apparent trade-off between these two clinically desirable goals may explain many of the common failure modes of bifurcation stenting.Nonstandard abbreviations used: main branch (MB); poly(ethylene glycol) (PEG); side branch (SB).

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Effects of wall shear stress and fluid recirculation on the localization of circulating monocytes in a three-dimensional flow model

Cited by 77 publications

References 24 publications

The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis

The influence of out-of-plane geometry on pulsatile flow within a distal end-to-side anastomosis

Quantitative Analysis of Bulk Flow in Image-Based Hemodynamic Models of the Carotid Bifurcation: The Influence of Outflow Conditions as Test Case

Dynamic flow alterations dictate leukocyte adhesion and response to endovascular interventions

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