William F. Pritchard, Peter F. Davies, Ziba Derafshi, Denise C. Polacek, Raychang Tsao, Randall O. Dull, Steven A. Jones, Don P. Giddens
Abstract:There is a correlation between the location of early atherosclerotic lesions and the hemodynamic characteristics at those sites. Circulating monocytes are key cells in the pathogenesis of atherosclerotic plaques and localize at sites of atherogenesis. The hypothesis that the distribution of monocyte adhesion to the vascular wall is determined in part by hemodynamic factors was addressed by studying monocyte adhesion in an in vitro flow model in the absence of any biological activity in the model wall. Suspensi…
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